{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:30:27Z","timestamp":1788856227945,"version":"build-2803163510"},"reference-count":15,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec id=\"ab-dbr230009-4\"><jats:title>Importance<\/jats:title><jats:p>Based on early studies, prurigo pigmentosa (PP) was considered a rare inflammatory dermatosis affecting primarily Asian individuals. However, several case reports subsequently showed that the disease is not restricted to those of Asian origin. Large studies on PP in central European individuals, on the other hand, are missing.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230009-5\"><jats:title>Objective<\/jats:title><jats:p>To increase awareness of PP by describing the clinical, histopathological, and immunohistochemical features in central European individuals.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230009-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This observational, retrospective case series analyzed clinicopathological features of 20 central European patients diagnosed with PP. Data collection was performed by means of archive material, including physician\u2019s letters, clinical photographs, and histopathological records, at the Department of Dermatology at the Medical University of Graz in Austria from January 1998 to January 2022.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230009-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Demographic, clinical, histopathological, and immunohistochemical characteristics for patients diagnosed with PP were recorded.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230009-8\"><jats:title>Results<\/jats:title><jats:p>Of the 20 patients included, 15 (75%) were female, and the mean (range) age was 24.1 (15-51) years. The study cohort consisted entirely of European patients. The most common site of involvement of PP was the breast, followed by the neck and back. Other involved clinical sites were the abdomen, shoulders, face, head, axillae, arms, and genital region and groin. Clinically, lesions were characterized by a symmetric pattern in 90% (n\u2009=\u200918) of all cases. Marked hyperpigmentation was observed only in 25% (n\u2009=\u20095) of patients. In some cases, triggers such as malnutrition, long-term pressure, and friction were noted. Histologic findings revealed presence of neutrophils in all cases and necrotic keratinocytes in 67% (n\u2009=\u200916) of cases. Immunohistochemistry results showed predominance of CD8<jats:sup>+<\/jats:sup> lymphocytes in the epidermis, as well as the presence of plasmacytoid dendritic cells and myeloid cell nuclear differentiation antigen\u2013positive neutrophil precursors.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230009-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>This case series found that most clinical features observed in Asian patients were also observed in central European patients, but hyperpigmentation was primarily mild to moderate. Histopathological features were similar to those reported in the literature with the additional presence of myeloid cell nuclear differentiation antigen\u2013positive precursor neutrophils. These results expand previous knowledge about PP in central European individuals.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2023.1917","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T15:01:36Z","timestamp":1689174096000},"page":"864","source":"Crossref","is-referenced-by-count":11,"title":["Clinical and Pathological Spectrum of Prurigo Pigmentosa in Central European Individuals"],"prefix":"10.1001","volume":"159","author":[{"given":"Carina","family":"Michor-Tscharre","sequence":"first","affiliation":[{"name":"Department of Dermatology, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"D\u2019Al\u00ec","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Udine, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cota","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Fink-Puches","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cerroni","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"key":"dbr230009r1","first-page":"38","article-title":"A peculiar pruriginous dermatosis with gross reticular pigmentation.","volume":"81","author":"Nagashima","year":"1971","journal-title":"Nippon Hifuka Gakkai 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