{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:22:50Z","timestamp":1791501770538,"version":"4.3.4"},"reference-count":53,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec id=\"ab-doi230026-4\"><jats:title>Importance<\/jats:title><jats:p>Patients and physicians often have differing opinions on the patient\u2019s disease severity. This phenomenon, termed <jats:italic>discordant severity grading<\/jats:italic> (<jats:italic>DSG<\/jats:italic>), hinders the patient-physician relationship and is a source of frustration.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230026-5\"><jats:title>Objective<\/jats:title><jats:p>To test and validate a model explaining the cognitive, behavioral, and disease factors associated with DSG.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230026-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>A qualitative study was first performed to derive a theoretical model. In this subsequent prospective cross-sectional quantitative study, the qualitatively derived theoretical model was validated using structural equation modeling (SEM). Recruitment was conducted between October 2021 and September 2022. This was a multicenter study in 3 Singapore outpatient tertiary dermatological centers. Dermatology patients and their attending physicians were recruited by convenience sampling. Patients were aged 18 to 99 years with psoriasis or eczema of at least 3 months\u2019 duration and recruited only once. The data were analyzed between October 2022 to May 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230026-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The outcome was the difference between global disease severity (0-10 numerical rating scale with a higher score indicating greater severity) as independently scored by the patient and the dermatologist. Positive discordance was defined as patient-graded severity more than 2 points higher (graded more severely) than physicians, and negative discordance if more than 2 points lower than physicians. Confirmatory factor analysis followed by SEM was used to assess the associations between preidentified patient, physician, and disease factors with the difference in severity grading.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230026-8\"><jats:title>Results<\/jats:title><jats:p>Of the 1053 patients (mean [SD] age, 43.5 [17.5] years), a total of 579 (55.0%) patients were male, 802 (76.2%) had eczema, and 251 (23.8%) had psoriasis. Of 44 physicians recruited, 20 (45.5%) were male, 24 (54.5%) were aged between 31 and 40 years, 20 were senior residents or fellows, and 14 were consultants or attending physicians. The median (IQR) number of patients recruited per physician was 5 (2-18) patients. Of 1053 patient-physician pairs, 487 pairs (46.3%) demonstrated discordance (positive, 447 [42.4%]; negative, 40 [3.8%]). Agreement between patient and physician rating was poor (intraclass correlation, 0.27). The SEM analyses showed that positive discordance was associated with higher symptom expression (standardized coefficient B\u2009=\u20090.12; <jats:italic>P<\/jats:italic>\u2009=\u2009.02) and greater quality-of-life impairment (B\u2009=\u20090.31; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001), but not patient or physician demographics. A higher quality-of-life impairment was in turn associated with lower resilience and stability (B\u2009=\u2009\u22120.23; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001), increased negative social comparisons (B\u2009=\u20090.45; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001), lower self-efficacy (B\u2009=\u2009\u22120.11; <jats:italic>P<\/jats:italic>\u2009=\u2009.02), increased disease cyclicity (B\u2009=\u20090.47; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001), and greater expectation of chronicity (B\u2009=\u20090.18; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001). The model was well-fitted (Tucker-Lewis: 0.94; Root Mean Square Error of Approximation: 0.034).<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230026-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>This cross-sectional study identified various modifiable contributory factors to DSG, increased understanding of the phenomenon, and set a framework for targeted interventions to bridge this discordance.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2023.2008","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T15:01:54Z","timestamp":1689174114000},"page":"811","source":"Crossref","is-referenced-by-count":37,"title":["Understanding Discordant Perceptions of Disease Severity Between Physicians and Patients With Eczema and Psoriasis Using Structural Equation Modeling"],"prefix":"10.1001","volume":"159","author":[{"given":"Valencia","family":"Long","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, 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