{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:56:32Z","timestamp":1791834992856,"version":"4.3.4"},"reference-count":15,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec id=\"ab-dbr230014-4\"><jats:title>Importance<\/jats:title><jats:p>Patients with vitiligo often have impaired quality of life (QOL) and experience substantial psychosocial burden.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230014-5\"><jats:title>Objective<\/jats:title><jats:p>To explore the global association of vitiligo with QOL and mental health from the patient perspective.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230014-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This qualitative study of the cross-sectional population-based Vitiligo and Life Impact Among International Communities (VALIANT) study was conducted from May 6, 2021, to June 21, 2021. Potential participants for this qualitative study were recruited from an online panel in 17 countries. Of 5859 surveyed adults (aged \u226518 years) who reported a vitiligo diagnosis, 3919 (66.9%) completed the survey, and 3541 (60.4%) were included in the analysis.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230014-7\"><jats:title>Exposures<\/jats:title><jats:p>Patients were asked questions regarding their emotional well-being, including QOL and mental health.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230014-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Reported analyses are descriptive and hypothesis generating. Vitiligo Impact Patient scale (VIPs) scores ranged from 0 to 60, with higher scores indicating more psychosocial burden.<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230014-9\"><jats:title>Results<\/jats:title><jats:p>The median age of the 3541 patients was 38 years (range, 18-95 years), and 1933 (54.6%) were male; 1602 patients (45.2%) had more than 5% affected body surface area (BSA; Self-Assessment Vitiligo Extent Score assessed), and 1445 patients (40.8%) had Fitzpatrick skin types IV to VI (ie, darker skin). The mean (SD) global short-form VIPs score was 27.3 (15.6) overall; patients from India (mean [SD], 40.2 [14.1]) reported the highest scores (ie, most burden). The QOL burden according to the scale was profound for patients with more than 5% affected BSA (mean [SD] score, 32.6 [14.2]), darker skin (mean [SD] score, 31.2 [15.6]), and lesions on the face (mean [SD] score, 30.0 [14.9]) or hands (mean [SD], 29.2 [15.2]). At least 40% of patients globally reported that vitiligo frequently affected aspects of their daily lives, including choosing clothes to wear (1956 of 3541 [55.2%]). Most patients (2103 of 3541 [59.4%]) reported concealing their vitiligo frequently. More than half of patients (2078 of 3541 [58.7%]) reported diagnosed mental health conditions, including anxiety (1019 of 3541 [28.8%]) and depression (866 of 3541 [24.5%]). The Patient Health Questionnaire\u20139 depression screener showed that 55.0% of patients (1948 of 3541) had moderate to severe depressive symptoms; the highest rates were in India (271 of 303 [89.4%]) and among patients with more than 5% affected BSA (1154 of 1602 [72.0%]) and darker skin (987 of 1445 [68.3%]).<\/jats:p><\/jats:sec><jats:sec id=\"ab-dbr230014-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>This qualitative study found that, globally, patients with vitiligo reported being substantially affected in their emotional well-being, daily lives, and psychosocial health; the burden was typically greatest among patients with more than 5% affected BSA, darker skin types, and lesions on the face or hands. Survey findings suggest that patients reported having altered their behavior, expressed clear discontent, and have symptoms consistent with depression, which may be underdiagnosed.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2023.2787","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T15:34:27Z","timestamp":1693409667000},"page":"1124","source":"Crossref","is-referenced-by-count":138,"title":["Mental Health and Psychosocial Quality-of-Life Burden Among Patients With Vitiligo"],"prefix":"10.1001","volume":"159","author":[{"given":"Kristen","family":"Bibeau","sequence":"first","affiliation":[{"name":"Incyte Corporation, Wilmington, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Ezzedine","sequence":"additional","affiliation":[{"name":"Henri Mondor University Hospital, Paris, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil Val de Marne, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Harris","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School, Worcester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanja","family":"van Geel","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearl","family":"Grimes","sequence":"additional","affiliation":[{"name":"Vitiligo & Pigmentation Institute of Southern California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[{"name":"Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Tulpule","sequence":"additional","affiliation":[{"name":"Shweta Association, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Gardner","sequence":"additional","affiliation":[{"name":"Vitiligo Support International, Lynchburg, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Valle","sequence":"additional","affiliation":[{"name":"Vitiligo Research Foundation, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaone","family":"Tlhong Matewa","sequence":"additional","affiliation":[{"name":"Beyond Vitiligo, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"LaFiura","sequence":"additional","affiliation":[{"name":"Envision Health Partners LLC, Riverside, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Lindley","sequence":"additional","affiliation":[{"name":"Incyte Corporation, Wilmington, 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