{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T03:49:16Z","timestamp":1772336956556,"version":"3.50.1"},"reference-count":15,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec id=\"ab-doi230047-4\"><jats:title>Importance<\/jats:title><jats:p>Objectively determining disease progression in craniofacial morphea (CM) is challenging, as clinical findings of disease activity are often lacking.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230047-5\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the utility of 3-dimensional (3D) stereophotogrammetry in detecting disease progression in CM over time.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230047-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This prospective cohort study included 27 pediatric and adult patients with CM from 2 hospitals in Boston (Boston Children\u2019s Hospital and Brigham &amp;amp;amp; Women\u2019s Hospital) consecutively enrolled from April 1, 2019, to March 1, 2023. Review of 3D stereophotogrammetry images and data analysis occurred from March 1 to April 1, 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230047-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Clinical and 3D stereophotogrammetry assessments were performed at 2- to 12-month intervals, depending on the clinical context. The 3D stereophotogrammetry images were then qualitatively rated as demonstrating no progression or definitive progression by an expert (board-certified plastic craniofacial surgeon) and nonexpert (board-certified dermatologist) in 3D stereophotogrammetry. In addition, \u03ba coefficients were calculated for interrater reliability.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230047-8\"><jats:title>Results<\/jats:title><jats:p>Of 27 patients with CM (19 female; median age, 14 [range, 5-40] years) and 3D stereophotogrammetry images obtained from a minimum of 2 time points (median, 4 [range, 2-10] images) spaced a median of 3 (range, 2-12) months apart, 10 experienced progression of their disease based on clinical assessments performed during the study period. In all cases in which clinical progression was favored, blinded qualitative assessment of 3D stereophotogrammetry images also favored progression with substantial interrater reliability (\u03ba\u2009=\u20090.80 [95% CI, 0.61-0.99]). Furthermore, review of 3D stereophotogrammetry detected occult progression of asymmetry not noted on clinical examination in 3 additional patients.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi230047-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this prospective cohort study, blinded assessment of sequential 3D stereophotogrammetry images in patients with CM not only corroborated clinical assessment of disease progression but also detected occult progression of facial asymmetry not appreciable on clinical examination alone. Therefore, 3D stereophotogrammetry may serve as a useful adjunct to clinical examination of patients with CM over time. Future investigations are warranted to validate 3D stereophotogrammetry as an outcome measure in CM.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2023.3649","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:02:53Z","timestamp":1697036573000},"page":"1232","source":"Crossref","is-referenced-by-count":6,"title":["Use of 3-Dimensional Stereophotogrammetry to Detect Disease Progression in Craniofacial Morphea"],"prefix":"10.1001","volume":"159","author":[{"given":"Katharina S.","family":"Shaw","sequence":"first","affiliation":[{"name":"Section of Dermatology, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Oral Surgery, Boston Children\u2019s 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