{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:19:00Z","timestamp":1792603140217,"version":"4.5.0"},"reference-count":23,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec id=\"ab-doi240008-4\"><jats:title>Importance<\/jats:title><jats:p>Early treatment of port-wine birthmark (PWB) can be life-altering and is often associated with improved outcomes and quality of life. There is growing evidence that shorter treatment intervals may play a role in more rapid PWB clearance; however, the optimal treatment interval has not been established.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240008-5\"><jats:title>Objective<\/jats:title><jats:p>To describe the outcomes of once-weekly pulsed dye laser (PDL) treatments for PWB in infants.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240008-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This case series analyzed the medical records of patients with PWB who received once-weekly PDL treatments between January 1, 2022, and December 31, 2023, at the Laser &amp;amp;amp; Skin Surgery Center of New York. These patients were younger than 6 months. Before-and-after treatment photographs were independently assessed and graded 2 months after initiation of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240008-7\"><jats:title>Intervention<\/jats:title><jats:p>Once-weekly PDL treatments.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240008-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The primary outcome was the percentage improvement of PWB, which was graded using the following scale: 0% (no improvement), 1% to 25% (mild improvement), 26% to 50% (moderate improvement), 51% to 75% (marked improvement), 76% to 95% (near-total clearance), and 96% to 100% (total clearance).<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240008-9\"><jats:title>Results<\/jats:title><jats:p>Of the 10 patients (6 males [60%]; median [range] age at first treatment, 4 [&amp;amp;lt;1 to 20] weeks) included, 7 (70%) had experienced either near-total clearance (76%-95%) or total clearance (96%-100%) of their PWB with once-weekly PDL treatments after 2 months. The other 3 patients all saw marked improvement (51%-75%) and subsequently went on to achieve near-total clearance with additional treatments. The median (range) duration of treatment and number of treatments to achieve near-total or total clearance in all patients were 2 (0.2-5.1) months and 8 (2-20) treatments, respectively. No adverse events were noted.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240008-10\"><jats:title>Conclusion and Relevance<\/jats:title><jats:p>This case series found that once-weekly PDL treatments for PWB in the first few months of life was associated with near-total or total clearance of PWB with no reported adverse events, suggesting improved outcomes can be achieved with shorter overall treatment duration. Further investigation into this novel decreased treatment interval of 1 week is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2024.0293","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T15:04:39Z","timestamp":1713366279000},"page":"606","source":"Crossref","is-referenced-by-count":18,"title":["Weekly Pulsed Dye Laser Treatments for Port-Wine Birthmarks in Infants"],"prefix":"10.1001","volume":"160","author":[{"given":"Shirin","family":"Bajaj","sequence":"first","affiliation":[{"name":"Laser & Skin Surgery Center of New York, New York"},{"name":"The Ronald O. Perelman Department of Dermatology at New York University Langone Health, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Tao","sequence":"additional","affiliation":[{"name":"Laser & Skin Surgery Center of New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Laser & Skin Surgery Center of New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy G.","family":"Geronemus","sequence":"additional","affiliation":[{"name":"Laser & Skin Surgery Center of New York, New York"},{"name":"The Ronald O. Perelman Department of Dermatology at New York University Langone Health, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"doi240008r1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1001\/jamadermatol.2020.4226","article-title":"Consensus statement for the management and treatment of port-wine birthmarks in Sturge-Weber syndrome.","volume":"157","author":"Sabeti","year":"2021","journal-title":"JAMA Dermatol"},{"issue":"11","key":"doi240008r2","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1097\/DSS.0000000000000525","article-title":"The natural history of soft tissue hypertrophy, bony hypertrophy, and nodule formation in patients with untreated head and neck capillary malformations.","volume":"41","author":"Lee","year":"2015","journal-title":"Dermatol Surg"},{"issue":"3","key":"doi240008r3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/1523-1747.ep12535052","article-title":"The nature and evolution of port wine stains: a computer-assisted study.","volume":"74","author":"Barsky","year":"1980","journal-title":"J Invest Dermatol"},{"issue":"3","key":"doi240008r4","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.jaad.2015.08.026","article-title":"Why do port-wine stains (PWS) on the lateral face respond better to pulsed dye laser (PDL) than those located on the central face?","volume":"74","author":"Yu","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"doi240008r5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1046\/j.1524-4725.2003.29010.x","article-title":"Long-term psychological impact and perceived efficacy of pulsed-dye laser therapy for patients with port-wine stains.","volume":"29","author":"Hansen","year":"2003","journal-title":"Dermatol Surg"},{"issue":"10","key":"doi240008r6","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1001\/archpedi.1995.02170230096014","article-title":"Initial lesion size as a predictive factor in determining the response of port-wine stains in children treated with the pulsed dye laser.","volume":"149","author":"Morelli","year":"1995","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"doi240008r7","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1046\/j.1365-2133.1998.02219.x","article-title":"Facial port wine stains in childhood: prediction of the rate of improvement as a function of the age of the patient, size and location of the port wine stain and the number of treatments with the pulsed dye (585 nm) laser.","volume":"138","author":"Nguyen","year":"1998","journal-title":"Br J Dermatol"},{"issue":"11","key":"doi240008r8","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/dsu.1994.20.issue-11","article-title":"Flashlamp-pumped pulsed dye laser treatment of port-wine stains.","volume":"20","author":"Fitzpatrick","year":"1994","journal-title":"J Dermatol Surg Oncol"},{"issue":"6","key":"doi240008r9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/lsm.v41:6","article-title":"Port wine stain progression: a potential consequence of delayed and inadequate treatment?","volume":"41","author":"Minkis","year":"2009","journal-title":"Lasers Surg Med"},{"issue":"7","key":"doi240008r10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/lsm.v39:7","article-title":"Efficacy of early treatment of facial port wine stains in newborns: a review of 49 cases.","volume":"39","author":"Chapas","year":"2007","journal-title":"Lasers Surg Med"},{"issue":"1","key":"doi240008r11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0022-3476(05)83489-4","article-title":"Treatment of port-wine stains (capillary malformation) with the flashlamp-pumped pulsed dye laser.","volume":"122","author":"Goldman","year":"1993","journal-title":"J Pediatr"},{"issue":"4","key":"doi240008r12","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1365-2133.2005.07113.x","article-title":"The treatment of port-wine stains with the pulsed-dye laser at 2-week and 6-week intervals: a comparative study.","volume":"154","author":"Tomson","year":"2006","journal-title":"Br J Dermatol"},{"issue":"5","key":"doi240008r13","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.jaad.2011.11.964","article-title":"Investigation into optimal treatment intervals of facial port-wine stains using the pulsed dye laser.","volume":"67","author":"Anolik","year":"2012","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"doi240008r14","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/bjd.2015.172.issue-3","article-title":"Topical axitinib suppresses angiogenesis pathways induced by pulsed dye laser.","volume":"172","author":"Gao","year":"2015","journal-title":"Br J Dermatol"},{"issue":"4","key":"doi240008r15","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1001\/jamadermatol.2018.5249","article-title":"Pulsed dye laser treatment of port-wine stains in infancy without the need for general anesthesia.","volume":"155","author":"Jeon","year":"2019","journal-title":"JAMA Dermatol"},{"issue":"2","key":"doi240008r16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jaad.2007.10.492","article-title":"Laser treatment of pediatric vascular lesions: port wine stains and hemangiomas.","volume":"58","author":"Stier","year":"2008","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"doi240008r17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/09546630310019355","article-title":"Survey of the practices of laser users in the UK in the treatment of port wine stains.","volume":"15","author":"Mahendran","year":"2004","journal-title":"J Dermatolog Treat"},{"issue":"4","key":"doi240008r18","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.jaad.2008.11.020","article-title":"Physiologic changes in vascular birthmarks during early infancy: mechanisms and clinical implications.","volume":"60","author":"Cordoro","year":"2009","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"doi240008r19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.otc.2017.09.004","article-title":"Capillary malformations (portwine stains) of the head and neck: natural history, investigations, laser, and surgical management.","volume":"51","author":"Lee","year":"2018","journal-title":"Otolaryngol Clin North Am"},{"key":"doi240008r20","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00238-022-01948-z","article-title":"The vanishing port-wine stain birthmark \u2014 consideration for a rare type of congenital vascular anomaly.","volume":"45","author":"Pellacani","year":"2022","journal-title":"Eur J Plast Surg"},{"issue":"4","key":"doi240008r21","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.jaad.2007.01.019","article-title":"Treatment of pulsed dye laser-resistant port wine stain birthmarks.","volume":"57","author":"Jasim","year":"2007","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"doi240008r22","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1001\/jamadermatol.2020.0363","article-title":"Assessment of outcomes with pulsed dye laser treatment of port-wine stains located proximally vs distally on extremities.","volume":"156","author":"Yu","year":"2020","journal-title":"JAMA Dermatol"},{"issue":"2","key":"doi240008r23","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1001\/archderm.1993.01680230066007","article-title":"Anatomical differences of port-wine stains in response to treatment with the pulsed dye laser.","volume":"129","author":"Renfro","year":"1993","journal-title":"Arch Dermatol"}],"container-title":["JAMA Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/articlepdf\/2817739\/jamadermatology_bajaj_2024_oi_240008_1717692704.69059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T15:01:01Z","timestamp":1718809261000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/2817739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamadermatol.2024.0293","relation":{},"ISSN":["2168-6068"],"issn-type":[{"value":"2168-6068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,1]]}}}