{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:33:36Z","timestamp":1775813616947,"version":"3.50.1"},"reference-count":33,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:sec id=\"ab-doi240071-4\"><jats:title>Importance<\/jats:title><jats:p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) cause diffuse epidermal detachment and necrosis. Patients who survive the initial SJS\/TEN episodes are affected by various sequelae.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240071-5\"><jats:title>Objective<\/jats:title><jats:p>To investigate the risks of cardiovascular morbidity and mortality in SJS\/TEN survivors.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240071-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This was a nationwide population-based cohort study using data from Taiwan\u2019s National Health Research Institute Database linked to the National Register of Death databases for 1998 to 2021. Survivors of SJS\/TEN were identified and matched with non-SJS\/TEN participants by age, sex, and Charlson Comorbidity Index. Data analysis was performed from November 2023 to June 2024.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240071-7\"><jats:title>Exposure<\/jats:title><jats:p>Cerebrovascular accidents (CVA) or ischemic heart disease (IHD) after SJS\/TEN survival.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240071-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Cox proportional hazards models were used to estimate the hazard ratios (HRs) of CVA and IHD morbidity and mortality after SJS\/TEN survival.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240071-9\"><jats:title>Results<\/jats:title><jats:p>The CVA cohort included 10\u202f571 SJS\/TEN survivors (mean [SD] age, 56.1 [18.5] years; 5358 females [50.7%] and 5213 males [49.3%]). The IHD cohort included 11\u202f084 SJS\/TEN survivors (mean [SD] age, 56.6 [18.6] years; 5561 females [50.2%] and 5523 males [49.8%]). The Cox proportional hazards model and competing risk regression model showed that compared with non-SJS\/TEN participants, patients with SJS\/TEN had higher risks of cardiovascular morbidity (CVA: HR, 1.65 [95% CI, 1.57-1.72] and subdistribution HR [sHR], 1.40 [95% CI, 1.33-1.46]; IHD: HR, 1.58 [95% CI, 1.51-1.65] and sHR, 1.32 [95% CI, 1.26-1.38]) and death due to cardiovascular disease (CVA: HR, 1.69; 95% CI, 1.46-1.96; IHD: HR, 1.55; 95% CI, 1.32-1.82). The increased cardiovascular mortality risks peaked at 1 year after SJS\/TEN and persisted for 4 to 7 years. Older survivors and survivors admitted to an intensive care unit at SJS\/TEN diagnosis had significantly higher cardiovascular mortality risk.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi240071-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this cohort study, SJS\/TEN had a lasting association with cardiovascular function after the acute phase. This suggests a need to mitigate the elevated cardiovascular morbidity and mortality risks among survivors. Further research using databases or registries with more comprehensive clinical data are needed to validate these results.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2024.5881","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T16:01:06Z","timestamp":1739980866000},"page":"391","source":"Crossref","is-referenced-by-count":3,"title":["Risk of Cardiovascular Morbidity and Mortality in Stevens-Johnson Syndrome\/Toxic Epidermal Necrolysis Survivors"],"prefix":"10.1001","volume":"161","author":[{"given":"Hsien-Yi","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Medical Research, National Taiwan University Hsin-Chu Hospital, Hsinchu, Taiwan"},{"name":"Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan"},{"name":"Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan"},{"name":"Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ming","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Allergy, Immunology, and Rheumatology, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung, Taiwan"},{"name":"Department of Nursing, Jen Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","reference":[{"issue":"3","key":"doi240071r1","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.jaad.2020.04.020","article-title":"Long-term sequelae from Stevens-Johnson syndrome\/toxic epidermal necrolysis in a large retrospective cohort.","volume":"84","author":"Wang","year":"2021","journal-title":"J Am Acad 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