{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:45:14Z","timestamp":1789753514212,"version":"4.0.1"},"reference-count":5,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"\n Importance<\/jats:title>\n Defining on-treatment remission in plaque psoriasis is important for benchmarking patient responses to therapies. This also helps to facilitate shared understanding, align treatment expectations, and enable more effective psoriasis management.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To establish a consensus-based definition of on-treatment remission for plaque psoriasis through a multistage Delphi initiative.<\/jats:p>\n <\/jats:sec>\n \n Evidence Review<\/jats:title>\n The Remission Workgroup from the medical board and scientific advisory board of the National Psoriasis Foundation engaged various stakeholders, both US based and international, to participate in the consensus process. Following a working group meeting to determine the overall consensus approach, a systematic review of remission definitions in the current literature was performed. This review helped to inform the content of consensus materials. The consensus effort involved 2 stages: pre-Delphi interviews and surveys to inform the Delphi questions, followed by a Delphi exercise with physicians to define on-treatment remission for plaque psoriasis. Outcome measures considered included body surface area (BSA), Investigator Global Assessment (IGA), the product of the Physician Global Assessment and body surface area (PGA\u2009\u00d7\u2009BSA), and Psoriasis Area and Severity Index (PASI) score at various cutoff levels and time points.<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n The consensus process involved 92 stakeholders, including dermatologists, rheumatologists, researchers, patients, payers, and life sciences professionals. In the pre-Delphi interviews and surveys, patients emphasized that on-treatment remission meant the absence of psoriasis signs and symptoms while recieving therapy. Payers expressed that defining remission is important for long-term treatment coverage. Following the Delphi exercise and discussion with participating physicians specializing in psoriatic disease management, on-treatment remission in plaque psoriasis was defined as patients maintaining a BSA of 0% or IGA of 0 for at least 6 months while on treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Through a Delphi consensus process, on-treatment remission for plaque psoriasis was defined as patients maintaining a BSA involvement of 0% or IGA of 0 for at least 6 months while on treatment. This clear and standardized benchmark is applicable to both research and practice settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamadermatol.2025.1625","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T11:00:49Z","timestamp":1750244449000},"page":"863","source":"Crossref","is-referenced-by-count":11,"title":["Defining On-Treatment Remission in Plaque Psoriasis"],"prefix":"10.1001","volume":"161","author":[{"given":"April W.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Gondo","sequence":"additional","affiliation":[{"name":"National Psoriasis Foundation, Alexandria, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Merola","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Departments of Dermatology and Medicine, O\u2019Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa M.","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of Hawaii at Manoa John A. Burns School of Medicine, Honolulu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes M.","family":"P\u00e9rez-Chada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak M. W.","family":"Balak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy S.","family":"Eakin","sequence":"additional","affiliation":[{"name":"National Psoriasis Foundation, Alexandria, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Read","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Southern California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie T.","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, Davis School of Medicine, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, Riverside School of 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Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel T.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, Davis School of Medicine, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Johnsen","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at University of California, Los Angeles, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Kalb","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State University of New York at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Kircik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Department of Dermatology, Indiana 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Michael","family":"Lewitt","sequence":"additional","affiliation":[{"name":"Illinois Dermatology Institute, Chicago, Illinois"},{"name":"DeNova Research, Chicago, Illinois"},{"name":"Rosalind Franklin University of Medicine and Science, Chicago Medical School, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanual","family":"Maverakis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, Davis School of Medicine, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Prussick","sequence":"additional","affiliation":[{"name":"Department of Dermatology, George Washington University School of Medicine, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, New York University Grossman School of Medicine, 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