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Searches combined Medical Subject Heading terms and keywords for atopic dermatitis and each environmental factor, with no language, date, or geographical restrictions.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi250025-8\"><jats:title>Data Extraction and Synthesis<\/jats:title><jats:p>Data were synthesized using random-effects models, with pooled estimates reported alongside 95% CIs, and the Grading of Recommendations Assessment, Development, and Evaluation was used to assess the certainty of the evidence across outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi250025-9\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Atopic dermatitis prevalence or severity.<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi250025-10\"><jats:title>Results<\/jats:title><jats:p>Of 11\u202f402 citations identified, 42 studies were included. There was an increase in atopic dermatitis outpatient clinic visits for every 10-\u03bcg\/m<jats:sup>3<\/jats:sup> increase in particulate matter 10 \u03bcm in diameter or less (risk ratio [RR], 1.008; 95% CI, 1.003-1.012; high certainty), particulate matter 2.5 \u03bcm in diameter or less (RR, 1.013; 95% CI, 0.999-1.027; moderate certainty), sulfur dioxide (RR, 1.029; 95% CI, 1.020-1.039; high certainty), and nitrogen dioxide (RR, 1.014; 95% CI, 0.999-1.030; moderate certainty). Extreme environmental temperatures (hot and cold) were are associated with increased atopic dermatitis\u2013related clinical visits (moderate to high certainty). Higher precipitation, including rain, may be associated with increased atopic dermatitis severity (low certainty), and higher levels of humidity are probably associated with increased atopic dermatitis severity (moderate certainty). Increased duration of sunlight exposure had an uncertain association with atopic dermatitis severity (very low certainty). Secondhand smoking exposure and traffic and industrial plant exposure are probably associated with increased atopic dermatitis prevalence (moderate certainty).<\/jats:p><\/jats:sec><jats:sec id=\"ab-doi250025-11\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The results of this systematic review and meta-analysis suggest that increased levels of environmental pollutants and temperature extremes are associated with increased population burden of atopic dermatitis. Measures to mitigate pollution and climate change may improve atopic dermatitis outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamadermatol.2025.1790","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:31:22Z","timestamp":1750851082000},"page":"828","source":"Crossref","is-referenced-by-count":28,"title":["Climate Conditions, Weather Changes, and Air Pollutants and Atopic Dermatitis"],"prefix":"10.1001","volume":"161","author":[{"given":"Megan","family":"Park","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiha T.","family":"Mohsen","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Katz","sequence":"additional","affiliation":[{"name":"Temerty Faculty of 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