{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:42:08Z","timestamp":1788219728740,"version":"build-2803163510"},"reference-count":6,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>This case report describes 2 patients taking osimertinib and amivantamab who developed ecthymalike ulcerations refractory to tetracyclines and topical steroids.<\/jats:p>","DOI":"10.1001\/jamadermatol.2026.1161","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:30:33Z","timestamp":1780500633000},"page":"756","source":"Crossref","is-referenced-by-count":1,"title":["Ecthymalike Ulcerations in Patients With Lung Cancer Treated With Combined Amivantamab and Osimertinib"],"prefix":"10.1001","volume":"162","author":[{"given":"Stephen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois"},{"name":"Assistant Section Editor, JAMA Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Nam","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"2","key":"dlo260005r1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1056\/NEJMoa2304594","article-title":"Overall survival with osimertinib in resected EGFR-mutated NSCLC.","volume":"389","author":"Tsuboi","year":"2023","journal-title":"N Engl J Med"},{"issue":"9","key":"dlo260005r2","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1093\/annonc\/mdi279","article-title":"Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors.","volume":"16","author":"Segaert","year":"2005","journal-title":"Ann Oncol"},{"issue":"2","key":"dlo260005r3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cllc.2022.11.004","article-title":"Amivantamab, an epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET) bispecific antibody, designed to enable multiple mechanisms of action and broad clinical applications.","volume":"24","author":"Cho","year":"2023","journal-title":"Clin Lung Cancer"},{"issue":"3","key":"dlo260005r4","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/annonc\/mdq387","article-title":"Interdisciplinary management of EGFR-inhibitor-induced skin reactions: a German expert opinion.","volume":"22","author":"Potthoff","year":"2011","journal-title":"Ann Oncol"},{"issue":"1","key":"dlo260005r5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1083\/jcb.200701086","article-title":"c-Met is essential for wound healing in the skin.","volume":"177","author":"Chmielowiec","year":"2007","journal-title":"J Cell Biol"},{"key":"dlo260005r6","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.926758","article-title":"Virulence factors of Pseudomonas aeruginosa and antivirulence strategies to combat its drug resistance.","volume":"12","author":"Liao","year":"2022","journal-title":"Front Cell Infect Microbiol"}],"container-title":["JAMA Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/articlepdf\/2849417\/jamadermatology_li_2026_lo_260005_1783528906.90346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:00:42Z","timestamp":1784127642000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/2849417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamadermatol.2026.1161","relation":{},"ISSN":["2168-6068"],"issn-type":[{"value":"2168-6068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}