{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:28:01Z","timestamp":1787153281909,"version":"build-2736575974"},"reference-count":14,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"\n Importance<\/jats:title>\n Increased intraocular pressure (IOP) is a known adverse effect of corticosteroid use and may lead to corticosteroid-induced glaucoma. However, clinical evidence on the impact of topical corticosteroids (TCS) on IOP is limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate changes in IOP during short-term treatment with periocular and whole-body TCS (studies 1 and 2) and systemic corticosteroids (study 3).<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This report includes the findings of 3 randomized clinical trials (RCTs) conducted at Herlev-Gentofte Hospital, University of Copenhagen (Denmark). Study 1 was an open-label RCT of patients with periocular atopic dermatitis (AD) and healthy controls, conducted from October 2021 to August 2023. Study 2 was a double-blind active comparator RCT of patients with AD conducted from September 2019 to March 2021. Study 3 was a double-blind RCT of male individuals with overweight or obesity and without diabetes conducted from December 2019 to June 2021. Data were analyzed from October 2024 to April 2025.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n In study 1, patients with AD and healthy controls applied periocular hydrocortisone (1.0%) cream or hydrocortisone-17-butyrate (0.1%) cream for 4 weeks; another group of healthy controls received no treatment. In study 2, patients with AD completed 2 weeks of whole-body betamethasone 17-valerate (0.1%) plus placebo or tacrolimus (0.1%) twice daily, followed by 4 weeks of twice-weekly treatment. In study 3, patients with AD received 10 days of oral placebo or prednisolone (50 mg) or prednisolone (50 mg) plus curcumin (400 mg).<\/jats:p>\n <\/jats:sec>\n \n Main Outcome<\/jats:title>\n Change in IOP\u2014the primary end point in study 1 and a predefined secondary end point in studies 2 and 3.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Study 1 included 24 patients, 8 with periocular atopic dermatitis (AD) and 16 healthy controls; study 2 included 36 patients with AD; and study 3 included 24 male individuals with overweight or obesity and without diabetes. The analysis of the 3 studies included a total of 84 participants (34 female [40.5%] and 50 male [59.5%] patients) with comparable baseline characteristics (mean [SD] age, 32 [9], 28 [10], and 46\u2009[14]\u2009years). In study 1, right eye IOP significantly decreased in patients with AD after treatment compared to untreated controls (\u20132.5 mm Hg; 95% CI, \u20133.9 to \u20131.1 mm Hg;\n P<\/jats:italic>\n \u2009=\u2009.002). No significant changes were observed in the left eye or among treated healthy controls. In studies 2 and 3, IOP remained stable, with no significant changes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In these 3 RCTs, short-term corticosteroid use, whether topical or systemic, did not appear to increase IOP. These findings support the ocular safety of short-term corticosteroid use.<\/jats:p>\n <\/jats:sec>\n \n Trial Registrations<\/jats:title>\n \n EU Clinical Trials Register Identifier:\n 2020-000252-35<\/jats:ext-link>\n ; ClinicalTrials.gov Identifier:\n NCT04114097<\/jats:ext-link>\n and\n NCT04315350<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamadermatol.2026.1183","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:00:28Z","timestamp":1778684428000},"page":"818","source":"Crossref","is-referenced-by-count":0,"title":["Intraocular Pressure During Short-Term Topical or Systemic Corticosteroid Treatment"],"prefix":"10.1001","volume":"162","author":[{"given":"Diva","family":"Amiri","sequence":"first","affiliation":[{"name":"Copenhagen Research Group for Inflammatory Skin, Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille H.","family":"Hellmann","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Dermatology and Venereology, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Copenhagen Research Group for Inflammatory Skin, Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kolko","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark"},{"name":"Your Eye Doctors, Rungsted Sundhedshus, Rungsted, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Gether","sequence":"additional","affiliation":[{"name":"Copenhagen Research Group for Inflammatory Skin, Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"Center for Clinical Metabolic Research, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"dbr260006r1","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.survophthal.2020.01.002","article-title":"Steroid-induced glaucoma: epidemiology, pathophysiology, and clinical management.","volume":"65","author":"Roberti","year":"2020","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"dbr260006r2","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/ajd.12292","article-title":"Ocular side-effects of topical corticosteroids: what a dermatologist needs to know.","volume":"56","author":"Daniel","year":"2015","journal-title":"Australas J Dermatol"},{"issue":"9083","key":"dbr260006r3","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/S0140-6736(97)03392-8","article-title":"Risk of ocular hypertension or open-angle glaucoma in elderly patients on oral 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