{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:41Z","timestamp":1791330041661,"version":"4.3.1"},"reference-count":20,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"\n Importance<\/jats:title>\n Isotretinoin is an effective treatment for moderate to severe acne, but concerns exist that exposure during adolescence could impair linear growth.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To examine whether isotretinoin use in adolescence is associated with reduced adult height.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This nationwide population-based cross-sectional study analyzed individuals eligible for military conscription in Denmark between January 1, 2001, and December 31, 2015, including all men and women volunteers. Conscription records were linked via unique personal identifiers to prospectively collected data from nationwide Danish registries. Individuals without a recorded height or with implausible height values were excluded. Data were analyzed from April 2025 to January 2026.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Prior use of isotretinoin, oral tetracycline-class antibiotics, or topical acne therapies, ascertained from linked prescription records before outcome assessment. Individuals without prescribed acne treatment or hospital-diagnosed acne served as the reference group.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Adult height measured at conscription. Linear regression models adjusted for birth cohort and educational level were used to estimate mean differences in height. The predefined minimal clinically important difference was 5 cm or greater. Analyses were stratified by age at isotretinoin initiation and cumulative dose before conscription. Stunting was examined as a secondary outcome.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study included 379\u202f196 individuals, of whom 368\u202f338 were men (16\u202f739 [4.5%] isotretinoin users) and 10\u202f858 were women (278 [2.6%] isotretinoin users). Median age at conscription was 19.0 years (IQR, 18.7-20.0 years) among men and 19.2 years (IQR, 18.7-20.5 years) among women. The mean (SD) height at age 19 years was 180.4 (6.7) cm in men and 168.3 cm (5.9) in women. There was little variation in adult height across exposures. Compared with the reference group, in the isotretinoin group, the adjusted mean difference in height was 0.31 cm (95% CI, 0.20-0.41 cm) among men and 0.25 cm (95% CI, \u22120.47 to 0.96 cm) among women; both estimates were below the predefined minimal clinically important difference. Findings were consistent across analyses stratified by age at initiation, cumulative dose, and when using stunting as the outcome.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this nationwide cross-sectional study, isotretinoin for acne was not associated with reduced adult height. These findings may inform evidence-based decision-making when considering isotretinoin treatment during adolescence.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamadermatol.2026.1197","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:30:39Z","timestamp":1779291039000},"page":"685","source":"Crossref","is-referenced-by-count":1,"title":["Isotretinoin Treatment in Adolescence and Adult Height"],"prefix":"10.1001","volume":"162","author":[{"given":"Sigrun Alba Johannesdottir","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese Koops","family":"Gr\u00f8nborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid Bjerge","family":"Gribsholt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u00e9ad M.","family":"Langan","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, England"},{"name":"Health Data Research UK, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Associate Editor, JAMA Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"1","key":"doi260015r1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1001\/jamadermatol.2023.4487","article-title":"Evaluation of stigma toward individuals with acne.","volume":"160","author":"Shields","year":"2024","journal-title":"JAMA Dermatol"},{"issue":"2","key":"doi260015r2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.jaad.2020.02.040","article-title":"Acne vulgaris and risk of depression and anxiety: a meta-analytic review.","volume":"83","author":"Samuels","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"doi260015r3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/bjd.19477","article-title":"Reviewing the global burden of acne: how could we improve care to reduce the burden?","volume":"184","author":"Layton","year":"2021","journal-title":"Br J Dermatol"},{"issue":"1","key":"doi260015r5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1515\/jom-2021-0108","article-title":"Analysis of the effects of isotretinoin on the premature epiphyseal closure in pediatric populations: a literature review.","volume":"122","author":"Alazawi","year":"2021","journal-title":"J Osteopath Med"},{"issue":"5","key":"doi260015r6","doi-asserted-by":"publisher","first-page":"S176","DOI":"10.1067\/mjd.2001.113721","article-title":"Isotretinoin effects on bone.","volume":"45","author":"DiGiovanna","year":"2001","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"doi260015r7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3390\/endocrines4020023","article-title":"Potential effects of oral isotretinoin on growth plate and height.","volume":"4","author":"Cardoso-Demartini","year":"2023","journal-title":"Endocrines"},{"issue":"6","key":"doi260015r8","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.jaad.2025.08.009","article-title":"The effect of isotretinoin treatment for acne vulgaris on height in adolescents: a retrospective cohort study using the Rochester Epidemiology Project.","volume":"93","author":"Xu","year":"2025","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"doi260015r9","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.jaad.2025.11.054","article-title":"Pediatric isotretinoin use for acne is not associated with meaningful effects on adult height: a retrospective cohort study using TriNetX.","volume":"94","author":"Cole","year":"2026","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"doi260015r10","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1093\/ije\/dyy048","article-title":"Data Resource Profile: Danish Conscription Registry Data (DCRD).","volume":"47","author":"Christensen","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"8","key":"doi260015r12","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish Civil Registration System as a tool in epidemiology.","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"doi260015r13","first-page":"798","article-title":"Data Resource Profile: the Danish National Prescription Registry.","volume":"46","author":"Potteg\u00e5rd","year":"2017","journal-title":"Int J Epidemiol"},{"key":"doi260015r14","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/CLEP.S91125","article-title":"The Danish National Patient Registry: a review of content, data quality, and research potential.","volume":"7","author":"Schmidt","year":"2015","journal-title":"Clin Epidemiol"},{"issue":"7","key":"doi260015r15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1177\/1403494810394715","article-title":"Danish education registers.","volume":"39","author":"Jensen","year":"2011","journal-title":"Scand J Public Health"},{"key":"doi260015r18","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2147\/CLEP.S179083","article-title":"The Danish health care system and epidemiological research: from health care contacts to database records.","volume":"11","author":"Schmidt","year":"2019","journal-title":"Clin Epidemiol"},{"issue":"7","key":"doi260015r19","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1093\/aje\/kwae358","article-title":"The healthy user effect in pharmacoepidemiology.","volume":"194","author":"Olawore","year":"2024","journal-title":"Am J Epidemiol"},{"issue":"7","key":"doi260015r20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002728","article-title":"Forty years trends in timing of pubertal growth spurt in 157,000 Danish school children.","volume":"3","author":"Aksglaede","year":"2008","journal-title":"PLoS One"},{"key":"doi260015r4","unstructured":"The Danish Health Data Authority. Statistics on the total sales of medicines in Denmark. Accessed January 16, 2026. https:\/\/medstat.dk\/en"},{"key":"doi260015r11","unstructured":"The Danish National Archives. The Danish Armed Forces Conscription Assessment System (1987-2015). Accessed January 16, 2026. https:\/\/digidata.rigsarkivet.dk\/aflevering\/19848"},{"key":"doi260015r16","unstructured":"World Health Organization. Physical status: the use of and interpretation of anthropometry\u2014report of a WHO expert committee. Accessed January 8, 2024. https:\/\/www.who.int\/publications-detail-redirect\/9241208546"},{"key":"doi260015r17","unstructured":"World Health Organization. Growth reference data for 5-19 years. Accessed January 8, 2024. https:\/\/www.who.int\/tools\/growth-reference-data-for-5to19-years"}],"container-title":["JAMA Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/articlepdf\/2848892\/jamadermatology_schmidt_2026_oi_260015_1783528901.85492.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:00:49Z","timestamp":1784127649000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/2848892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamadermatol.2026.1197","relation":{},"ISSN":["2168-6068"],"issn-type":[{"value":"2168-6068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}