{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:46:48Z","timestamp":1792597608716,"version":"4.5.0"},"reference-count":31,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"\n Importance<\/jats:title>\n The exposome has been proposed to have a key role in the development of atopic dermatitis (AD). However, whether early-life infections are associated with AD risk remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate whether early infection burden and infection subtypes are associated with the risk of childhood AD.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n \n A cohort study using data from children aged 0 to 10 years from the 2010 Danish Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010) birth cohort who were monitored for infection diagnoses, AD diagnosis, Scoring Atopic Dermatitis (SCORAD) index score, systemic antibiotics, and filaggrin gene (\n FLG<\/jats:italic>\n ) status. Replication was sought in a second birth cohort from the US Vitamin D Antenatal Asthma Reduction Trial (VDAART) cohort. Data were analyzed between January and February 2026.\n <\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Daily diary-registered infection episodes of cold, acute otitis media, tonsillitis, pneumonia, gastroenteritis, and fever episodes and days until age 3 years in COPSAC2010. Cold, fever, respiratory infection, and fever episodes until age 3 years in VDAART.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n \n Risk of AD during age 0 to 10 years using diagnostic criteria with longitudinal risk assessment from a generalized estimating equation (GEE) model in COPSAC2010. Analyses adjusted for\n FLG<\/jats:italic>\n variant and systemic antibiotic treatments. Parental report of physician AD diagnosis until age 6 years was used in VDAART.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 663 children in COPSAC2010, children in the upper (n\u2009=\u2009221; 112 males [51%], 109 females [49%]) vs lower (n\u2009=\u2009221; 109 males [49%], 112 females [51%]) tertiles of infection episodes and days were associated with higher risk of yearly AD prevalence during ages 0 to 10 years (GEE model): adjusted odds ratio (AOR), 1.61; 95% CI, 1.05-2.47;\n P<\/jats:italic>\n \u2009=\u2009.03; and AOR, 1.69; 95% CI, 1.11-2.58;\n P<\/jats:italic>\n \u2009=\u2009.01, respectively. Each infection episode was associated with a higher AD risk as well, independently of systemic antibiotic treatments and\n FLG<\/jats:italic>\n variants. Associations were mainly driven by respiratory infections. In VDAART (n\u2009=\u2009707), children in the upper (n\u2009=\u2009235; 125 males [53%], 110 females [47%]) vs lower (n\u2009=\u2009236; 119 males [50%], 117 females [50%]) tertiles of infection episodes were associated with a higher risk of AD at ages 0 to 6 years (OR, 1.76; 95% CI, 1.16-2.70;\n P<\/jats:italic>\n \u2009=\u2009.01), increasing by each infection episode (OR, 1.03; 95% CI, 1.01-1.05;\n P<\/jats:italic>\n \u2009=\u2009.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n This study found that early respiratory infection burden is associated with AD diagnosis in a dose-dependent manner in 2 independent birth cohorts. These findings suggest a long-term relationship between early respiratory infections and AD that has previously been unclear due to inconsistent findings in previous studies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamadermatol.2026.2626","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:30:38Z","timestamp":1785339038000},"page":"982","source":"Crossref","is-referenced-by-count":0,"title":["Early Respiratory Infection Burden and Atopic Dermatitis in Childhood"],"prefix":"10.1001","volume":"162","author":[{"given":"Nicklas","family":"Brustad","sequence":"first","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gomes","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalie","family":"Klein","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Marie Malby","family":"Schoos","sequence":"additional","affiliation":[{"name":"Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Pediatrics, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Prince","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lasky-Su","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"B\u00f8nnelykke","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of 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