{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:47:26Z","timestamp":1792597646955,"version":"4.5.0"},"reference-count":65,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Dermatol"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec id=\"ab-doi260035-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Neurofibromatosis type 1 (NF1) is a multisystem, tumor predisposition syndrome in which vascular manifestations, including cutaneous lesions, remain poorly characterized. Cherry angiomas (CAs) have been sporadically reported in NF1, but their prevalence and biological basis are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-doi260035-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between NF1 and CAs and define the histopathologic, cellular, and genetic mechanisms underlying NF1-associated CAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-doi260035-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This prospective, comparative, cross-sectional epidemiological study was conducted from October 2020 to March 2021 at a French national referral center for neurofibromatoses within the dermatology department at Henri-Mondor University Hospital, Cr\u00e9teil, France. It was followed by integrated histopathologic, genomic, and cell-specific molecular analyses. The epidemiological analysis included individuals 15 years or older with confirmed NF1 and controls without NF1. Pathophysiological analyses were conducted on CAs from individuals with NF1 and healthy volunteers following written consent. Data were analyzed in 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-doi260035-7\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>\n                      Outcomes included the prevalence of CAs; age-adjusted and sex-adjusted odds ratios; histopathologic features; detection of somatic\n                      <jats:italic toggle=\"yes\">NF1<\/jats:italic>\n                      second-hit variants; identification of co-occurring oncogenic variants; localization of\n                      <jats:italic toggle=\"yes\">NF1<\/jats:italic>\n                      loss within vascular cell populations; and evidence of rat sarcoma\u2013mitogen-activated protein kinase pathway activation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-doi260035-8\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 259 participants (125 female individuals [48.3%]), 102 (39.4%) individuals had NF1 (median [range] age, 34 [18-70] years) and 157 (60.6%) were controls (median [range] age, 40 [15-91] years). CAs were more frequent in individuals with NF1 than controls (48% vs 18%; odds ratio, 4.26; 95% CI, 2.44-7.56) and occurred at a younger age. This association persisted after adjustment for age and sex and in propensity score\u2013matched analyses. Somatic\n                      <jats:italic toggle=\"yes\">NF1<\/jats:italic>\n                      loss-of-function second hits were identified in 26 of 39 of NF1-associated CAs (67%) and none from controls, indicating biallelic\n                      <jats:italic toggle=\"yes\">NF1<\/jats:italic>\n                      inactivation. Comprehensive genomic profiling revealed frequent co-occurring activating variants, most commonly in\n                      <jats:italic toggle=\"yes\">GNAQ<\/jats:italic>\n                      . Cell-specific sequencing showed that\n                      <jats:italic toggle=\"yes\">NF1<\/jats:italic>\n                      second hits arose predominantly in endothelial cells and telocytes, with higher variant allele frequencies in endothelial cells. Immunofluorescence demonstrated increased phosphoextracellular signal-regulated kinase signaling in these vascular cell populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-doi260035-9\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>\n                      The results of this cross-sectional study suggest that CAs represent a frequent and previously unrecognized vascular manifestation of NF1, which is supported by epidemiological enrichment and mechanistic evidence of biallelic\n                      <jats:italic toggle=\"yes\">NF1<\/jats:italic>\n                      inactivation in vascular cells. These findings potentially expand the spectrum of NF1-associated neoplasms and establish CAs as a model for NF1-related vasculopathy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamadermatol.2026.2933","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:30:32Z","timestamp":1787153432000},"page":"989","source":"Crossref","is-referenced-by-count":0,"title":["Cherry Angiomas in Individuals With Neurofibromatosis Type 1"],"prefix":"10.1001","volume":"162","author":[{"given":"Laura","family":"Fertitta","sequence":"first","affiliation":[{"name":"Dermatology Department, Referral Center for Neurofibromatoses, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, Paris Est Cr\u00e9teil University, Cr\u00e9teil, France"},{"name":"INSERM U955, Mondor Institute of Biomedical Research, Cr\u00e9teil, France"},{"name":"INSERM, Clinical Investigation Center 1430, Centre de R\u00e9f\u00e9rence des 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