{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:39:41Z","timestamp":1777642781784,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JAMA Facial Plast Surg"],"published-print":{"date-parts":[[2014,7]]},"abstract":"\n Importance<\/jats:title>\n These data may be useful for developing guidelines for clinicians and the general population related to the reversal of photoaging effects on the aging face damaged by solar radiation.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate antiaging effects of 4 commercially available topical agents on the dorsal skin in photoaged hairless mice.<\/jats:p>\n <\/jats:sec>\n \n Design and Setting<\/jats:title>\n Animal study at an academic medical center. Animals comprised 56 female Skh-1 hairless mice (6-8 weeks old). Skin samples were collected from nonirradiated intact mice (control), mice irradiated with UV-B for 8 weeks, mice irradiated with UV-B and then exposed to a topical cosmeceutical applied for 5 weeks, and UV-B-irradiated mice not exposed to cosmeceuticals and retained for 5 weeks until the end of the experiment.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n The mice were exposed to UV-B light 3 times a week for 2 months, followed by topical application of a peptide, antioxidant, estrogen, and retinoic acid agent for 5 weeks.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Surface features such as wrinkling were analyzed from replicas along with histomorphometric determination of epidermal thickness, sebocyte counts, and immunohistochemical study of proliferating cell nuclear antigen (PCNA).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Exposure to UV-B induced significant wrinkle formation after 13 weeks, which was attenuated with treatments with a peptide cream, antioxidant mixture, and estrogen cream (mean [SD] Rz values: control [C], 60.7 [19.0]; irradiated [RAD], 51.8 [15.9] [\n P<\/jats:italic>\n \u2009<\u2009.001]; irradiated-long [RAD-long], 86.0 [28.3] [\n P<\/jats:italic>\n \u2009=\u2009.01]; antioxidant [AO], 45.2 [13.2]; peptide, 63.4 [18.8], estrogen, 64.6 [21.2]; retinoic acid [RA], 73.9 [28.5]; RAD-long vs C [\n P<\/jats:italic>\n \u2009=\u2009.01], vs RAD [\n P<\/jats:italic>\n \u2009<\u2009.001], vs estrogen [\n P<\/jats:italic>\n \u2009=\u2009.04], vs peptide [\n P<\/jats:italic>\n \u2009=\u2009.02], vs AO [\n P<\/jats:italic>\n <.001], vs RA [\n P<\/jats:italic>\n \u2009=\u2009.25]. There was a trend of reversal of irradiation-induced augmentation of epidermal thickness in animals treated with the peptide and AO (mean [SD] epidermal width: C, 21.0 [2.2] \u03bcm; RAD, 41.3 [7.0] \u03bcm [\n P<\/jats:italic>\n \u2009<\u2009.001]; RAD-long, 39.1 [11.0] \u03bcm [\n P<\/jats:italic>\n \u2009=\u2009.006]; AO, 37.3 [14] \u03bcm [\n P<\/jats:italic>\n \u2009<\u2009.001]; peptide, 33.9 [3.8] \u03bcm [\n P<\/jats:italic>\n \u2009=\u2009.01]; estrogen, 59.2 [9.2] \u03bcm [\n P<\/jats:italic>\n \u2009=\u2009.003]; RA, 52.4 [8.7] \u03bcm [\n P<\/jats:italic>\n \u2009<\u2009.001]). Retinoic acid augmented epidermal width and sebocyte counts (mean [SD] sebocyte data [number per gland]: C, 9.4 [2.0]; RAD, 11.69 [1.5] [\n P<\/jats:italic>\n \u2009<\u2009.001]; RAD-long, 6.5 [1.3] [\n P<\/jats:italic>\n \u2009=\u2009.73]; peptide, 7.2 [1.7] [\n P<\/jats:italic>\n \u2009=\u2009.03]; estrogen, 4.1 [0.9] [\n P<\/jats:italic>\n \u2009<\u2009.001]; AO, 7.2 [1.7] [\n P<\/jats:italic>\n \u2009=\u2009.06]; RA, 11.0 [1.4] [\n P<\/jats:italic>\n \u2009=\u2009.01]). Estrogen cream was effective in restoring surface features but enhanced thickness of epidermis in irradiated specimens. All groups had a higher PCNA index score except for peptide treatment, which brought it down to the control level (mean [SD] PCNA index values: C, 17.3 [1.5]; RAD, 32.4 [6.8] [\n P<\/jats:italic>\n \u2009<\u2009.001]; RAD-long, 34.0 [6.1] [\n P<\/jats:italic>\n \u2009<\u2009.001]; AO, 62.1 [3.5] [\n P<\/jats:italic>\n \u2009=\u2009.01]; peptide, 20.1 [6.3] [\n P<\/jats:italic>\n \u2009<\u2009.001]; estrogen, 56.8 [10.0] [\n P<\/jats:italic>\n \u2009<\u2009.001]; RA, 35.2 [10.2] [\n P<\/jats:italic>\n \u2009<\u2009.001]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Of the 4 cosmeceuticals tested within this experimental period, peptide cream and antioxidant mixture were the most effective overall in reversing photoaging effects; retinoic acid was the least effective of these topical agents.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n NA<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamafacial.2013.2582","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T18:31:13Z","timestamp":1401388273000},"page":"253-260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Cosmeceutical Effect on Skin Surface Profiles and Epidermis in UV-B\u2013Irradiated Mice"],"prefix":"10.1177","volume":"16","author":[{"given":"Tapan K.","family":"Bhattacharyya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head & Neck Surgery, University of Illinois at Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohini","family":"Pathria","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head & Neck Surgery, University of Illinois at Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clyde","family":"Mathison","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head & Neck Surgery, University of Illinois at Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head & Neck Surgery, University of Illinois at Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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