{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:56:23Z","timestamp":1792119383625,"version":"4.4.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JAMA Facial Plast Surg"],"published-print":{"date-parts":[[2017,9]]},"abstract":"\n Importance<\/jats:title>\n Patients with cleft palate and other causes of velopharyngeal insufficiency (VPI) suffer adverse effects on social interactions and communication. Measurement of these patient-reported outcomes is needed to help guide surgical and nonsurgical care.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To further validate the VPI Effects on Life Outcomes (VELO) instrument, measure the change in quality of life (QOL) after speech surgery, and test the association of change in speech with change in QOL.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n Prospective descriptive cohort including children and young adults undergoing speech surgery for VPI in a tertiary academic center. Participants completed the validated VELO instrument before and after surgical treatment.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The main outcome measures were preoperative and postoperative VELO scores and the perceptual speech assessment of speech intelligibility. The VELO scores are divided into subscale domains. Changes in VELO after surgery were analyzed using linear regression models. VELO scores were analyzed as a function of speech intelligibility adjusting for age and cleft type. The correlation between speech intelligibility rating and VELO scores was estimated using the polyserial correlation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty-nine patients (13 males and 16 females) were included. Mean (SD) age was 7.9 (4.1) years (range, 4-20 years). Pharyngeal flap was used in 14 (48%) cases, Furlow palatoplasty in 12 (41%), and sphincter pharyngoplasty in 1 (3%). The mean (SD) preoperative speech intelligibility rating was 1.71 (1.08), which decreased postoperatively to 0.79 (0.93) in 24 patients who completed protocol (\n P<\/jats:italic>\n \u2009<\u2009.01). The VELO scores improved after surgery (\n P<\/jats:italic>\n \u2009<\u2009.001) as did most subscale scores. Caregiver impact did not change after surgery (\n P<\/jats:italic>\n \u2009=\u2009.36). Speech Intelligibility was correlated with preoperative and postoperative total VELO score (\n P<\/jats:italic>\n \u2009<\u2009.01) and to preoperative subscale domains (situational difficulty [VELO-SiD,\n P<\/jats:italic>\n \u2009=\u2009.005] and perception by others [VELO-PO,\n P<\/jats:italic>\n \u2009=\u2009.05]) and postoperative subscale domains (VELO-SiD [\n P<\/jats:italic>\n \u2009=\u2009.03], VELO-PO [\n P<\/jats:italic>\n \u2009=\u2009.003]). Neither the VELO total nor subscale score change after surgery was correlated with change in speech intelligibility.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Speech surgery improves VPI-specific quality of life. We confirmed validation in a population of untreated patients with VPI and included pharyngeal flap surgery, which had not previously been included in validation studies. The VELO instrument provides patient-specific outcomes, which allows a broader understanding of the social, emotional, and physical effects of VPI.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n 2<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamafacial.2017.0639","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T12:33:54Z","timestamp":1500554034000},"page":"406-412","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":73,"title":["Association of Velopharyngeal Insufficiency With Quality of Life and Patient-Reported Outcomes After Speech Surgery"],"prefix":"10.1177","volume":"19","author":[{"given":"Aditi","family":"Bhuskute","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California, Davis, Sacramento."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Skirko","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California, Davis, Sacramento."},{"name":"Division of Pediatric Otolaryngology, University of Utah, Salt Lake City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California, Davis, Sacramento."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Bayoumi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California, Davis, Sacramento."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blythe","family":"Durbin-Johnson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology, University of Utah, Salt Lake City."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Primary Children's Medical Center, Salt Lake City, Utah."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis T.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of California, Davis, Sacramento."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"Biavati MJ Rocha-Worley G Wiet GJ. Velopharyngeal Insufficiency. Medscape. http:\/\/emedicine.medscape.com\/article\/873018-overview. Accessed October30 2013."},{"key":"e_1_3_1_3_2","unstructured":"Parameters for Evaluation and Treatment of Patients with Cleft Lip\/Palate or Other Craniofacial Anomalies. American Cleft Palate-Craniofacial Association. Revised; 2009. http:\/\/www.acpa-cpf.org\/uploads\/site\/Parameters_Rev_2009.pdf. Accessed March1 2015."},{"key":"e_1_3_1_4_2","unstructured":"ASHA. (2012). How Does Your Child Hear and Talk. http:\/\/www.asha.org\/public\/speech\/development\/chart.htm. Accessed February12 2016."},{"key":"e_1_3_1_5_2","unstructured":"Cleft Palate Foundation. (2012). Speech Development. http:\/\/www.cleftline.org\/publications\/speech. Accessed February12 2016."},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2015.0093"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1597\/05-080"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1597\/07-124.1"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1597\/06-233.1"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01588.x"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31822b6a67"},{"issue":"8","key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1001\/archotol.128.8.919","article-title":"Validation of a pediatric voice quality-of-life instrument: the pediatric voice outcome survey","volume":"128","author":"Hartnick CJ","year":"2002","unstructured":"Hartnick CJ. Validation of a pediatric voice quality-of-life instrument: the pediatric voice outcome survey. Arch Otolaryngol Head Neck Surg. 2002; 128(8):919-922.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.06.002"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.7.717"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813486081"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815591159"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1597\/06-086.1"},{"key":"e_1_3_1_18_2","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria. (2016) URL http:\/\/www.R-project.org\/. Accessed June13 2016."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294164"},{"issue":"4","key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/jamafacial.2015.0164","article-title":"Developing a novel speech intervention ipad game for children with cleft palate: a pilot study","volume":"17","author":"Hsieh TY","year":"2015","unstructured":"Hsieh TY, , Funamura JL, , Roth C, , Rubin Z, , Kurniawan S, , Tollefson TT. Developing a novel speech intervention ipad game for children with cleft palate: a pilot study. 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