{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:07:55Z","timestamp":1791821275597,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["JAMA Facial Plast Surg"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Hyaluronic acid filler can be safely used as a soft-tissue filler for correction of infraorbital hollowing. It has a high overall patient satisfaction profile among patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report safety and patient satisfaction outcomes of Juv\u00e9derm Voluma XC for correction of infraorbital hollows.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Patients<\/jats:title>\n                    <jats:p>This was a retrospective observational study performed at a private ambulatory facial plastic and reconstructive surgery practice. Participants were all patients 21 to 85 years old who presented to our practice and underwent Juv\u00e9derm Voluma XC treatment for correction of infraorbital hollows as a singular intervention from February 2016 to March 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Injection of Juv\u00e9derm Voluma XC to the tear trough, nasojugal fold, and\/or palpebromalar groove.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Primary outcome measures include the number of recorded short- and long-term adverse events, need for additional treatment, and patient questionnaire FACE-Q scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 202 eyes were treated in 101 patients with a mean follow-up of 12 months. Patients were principally female (90 [89%]) with an average age of 54 years (range, 21-85 years). Most patients (99) had Fitzpatrick grade 1 to 4 skin type (98%) and had an infraorbital hollows score of 2 to 4 (89 [88%]). The average initial treatment volume was 1 mL with 18 patients (18%) requiring additional treatment within 3 months. The average time until additional treatment was 35.7 days. Adverse effects include bruising (in 10 [10%], contour irregularities (2 [2%]), swelling (3 [3%]), and Tyndall effect (1 [1%]). Hyaluronidase was required in 3 patients (3%). Forty-one patients completed the FACE-Q Satisfaction With Eyes survey, and 42 patients completed the FACE-Q Satisfaction With Decision survey (41% and 42%). Overall mean (SD) patient satisfaction (based on FACE-Q scores) was 71.1% (27.3) and 65.6% (31.3), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>Juv\u00e9derm Voluma XC has a high patient satisfaction profile and an acceptable safety profile for the correction of infraorbital hollowing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/jamanetwork.com\/journals\/jamafacialplasticsurgery\/pages\/instructions-for-authors\/#SecLevelofEvidence\/Ethnicity\">4<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamafacial.2018.0230","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T12:52:31Z","timestamp":1523019151000},"page":"367-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Novel Use of a Volumizing Hyaluronic Acid Filler for Treatment of Infraorbital Hollows"],"prefix":"10.1177","volume":"20","author":[{"given":"Michael B.","family":"Hall","sequence":"first","affiliation":[{"name":"Buckingham Center for Facial Plastic Surgery, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Roy","sequence":"additional","affiliation":[{"name":"Buckingham Center for Facial Plastic Surgery, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Buckingham","sequence":"additional","affiliation":[{"name":"Buckingham Center for Facial Plastic Surgery, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"issue":"6","key":"e_1_3_1_2_2","first-page":"30","article-title":"Comprehensive treatment of periorbital region with hyaluronic acid","volume":"8","author":"Bravo BS","year":"2015","unstructured":"Bravo BS, , Rocha CR, , Bastos JT, , Silva PM. Comprehensive treatment of periorbital region with hyaluronic acid. J Clin Aesthet Dermatol. 2015; 8(6):30-35. 26155325","journal-title":"J Clin Aesthet Dermatol"},{"issue":"1","key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.fsc.2006.10.006","article-title":"Fillers in the periorbital complex","volume":"15","author":"Finn JC","year":"2007","unstructured":"Finn JC, , Cox S. Fillers in the periorbital complex. Facial Plast Surg Clin North Am. 2007; 15(1):123-132, viii. 17317563","journal-title":"Facial Plast Surg Clin North Am"},{"issue":"11","key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/dsu.12343","article-title":"Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study","volume":"39","author":"Jones D","year":"2013","unstructured":"Jones D, , Murphy DK. Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013; 39(11):1602-1612. 24093664","journal-title":"Dermatol Surg"},{"issue":"4","key":"e_1_3_1_5_2","first-page":"629","article-title":"Hyaluronic acid gel (Juv\u00e9derm) preparations in the treatment of facial wrinkles and folds","volume":"3","author":"Bogdan Allemann I","year":"2008","unstructured":"Bogdan Allemann I, , Baumann L. Hyaluronic acid gel (Juv\u00e9derm) preparations in the treatment of facial wrinkles and folds. Clin Interv Aging. 2008; 3(4):629-634. 19281055","journal-title":"Clin Interv Aging"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S40581"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjv050"},{"issue":"8","key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/DSS.0000000000000416","article-title":"Duration of effect by injection volume and facial subregion for a volumizing hyaluronic acid filler in treating midface volume deficit","volume":"41","author":"Glaser DA","year":"2015","unstructured":"Glaser DA, , Kenkel JM, , Paradkar-Mitragotri D, , Murphy DK, , Romagnano L, , Drinkwater A. Duration of effect by injection volume and facial subregion for a volumizing hyaluronic acid filler in treating midface volume deficit. Dermatol Surg. 2015; 41(8):942-949. 26218727","journal-title":"Dermatol Surg"},{"issue":"5","key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/01.iop.0000235820.00633.61","article-title":"Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections","volume":"22","author":"Goldberg RA","year":"2006","unstructured":"Goldberg RA, , Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections. Ophthal Plast Reconstr Surg. 2006; 22(5):335-341. 16985414","journal-title":"Ophthal Plast Reconstr Surg"},{"issue":"2","key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/IOP.0b013e3181b80f93","article-title":"Use of hyaluronic acid filler for tear-trough rejuvenation as an alternative to lower eyelid surgery","volume":"27","author":"Morley AM","year":"2011","unstructured":"Morley AM, , Malhotra R. Use of hyaluronic acid filler for tear-trough rejuvenation as an alternative to lower eyelid surgery. Ophthal Plast Reconstr Surg. 2011; 27(2):69-73. 20551859","journal-title":"Ophthal Plast Reconstr Surg"},{"issue":"4","key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/0974-2077.104910","article-title":"Dermal fillers for treatment of tear trough deformity: a review of anatomy, treatment techniques and their outcomes","volume":"5","author":"Sharad J","year":"2012","unstructured":"Sharad J. Dermal fillers for treatment of tear trough deformity: a review of anatomy, treatment techniques and their outcomes. J Cutan Aesthet Surg. 2012; 5(4):229-238. 23378704","journal-title":"J Cutan Aesthet Surg"},{"issue":"5","key":"e_1_3_1_12_2","first-page":"344","article-title":"dermal fillers for the treatment of tear trough deformity: a review of anatomy, treatment techniques, and their outcomes","volume":"22","author":"Steinsapir KD","year":"2006","unstructured":"Steinsapir KD, , Steinsapir SM. dermal fillers for the treatment of tear trough deformity: a review of anatomy, treatment techniques, and their outcomes. Ophthal Plast Reconstr Surg. 2006; 22(5):344-348. 16985416","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2147\/CCID.S84117","article-title":"Correction of tear trough deformity with a cohesive polydensified matrix hyaluronic acid: a case series","volume":"8","author":"Huber-Vorl\u00e4nder J","year":"2015","unstructured":"Huber-Vorl\u00e4nder J, , K\u00fcrten M. Correction of tear trough deformity with a cohesive polydensified matrix hyaluronic acid: a case series. Clin Cosmet Investig Dermatol. 2015; 8:307-312. 26170706","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000856"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2016.1018"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000895"},{"key":"e_1_3_1_17_2","unstructured":"American Society of Plastic Surgeons Annual Procedural Statistics. 2016. https:\/\/www.plasticsurgery.org\/news\/plastic-surgery-statistics?sub=2016+Plastic+Surgery+Statistics. Accessed March 5 2018."},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2015.42.1.46"},{"issue":"2","key":"e_1_3_1_19_2","doi-asserted-by":"crossref","first-page":"272e","DOI":"10.1097\/PRS.0000000000001439","article-title":"FACE-Q scales for health-related quality of life, early life impact, satisfaction with outcomes, and decision to have treatment: development and validation","volume":"136","author":"Barone M","year":"2015","unstructured":"Barone M, , Cogliandro A, , Cagli B, , Persichetti P. FACE-Q scales for health-related quality of life, early life impact, satisfaction with outcomes, and decision to have treatment: development and validation. Plast Reconstr Surg. 2015; 136(2):272e-273e. 26218401","journal-title":"Plast Reconstr Surg"},{"issue":"10","key":"e_1_3_1_20_2","first-page":"38","article-title":"Improvement of tear trough by monophasic hyaluronic acid and calcium hydroxylapatite","volume":"7","author":"Wollina U","year":"2014","unstructured":"Wollina U. Improvement of tear trough by monophasic hyaluronic acid and calcium hydroxylapatite. J Clin Aesthet Dermatol. 2014; 7(10):38-43. 25371770","journal-title":"J Clin Aesthet Dermatol"},{"issue":"1","key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1090820X10391213","article-title":"Nonsurgical rejuvenation of the aging face with injectable poly-L-lactic acid for restoration of soft tissue volume","volume":"31","author":"Schierle CF","year":"2011","unstructured":"Schierle CF, , Casas LA. Nonsurgical rejuvenation of the aging face with injectable poly-L-lactic acid for restoration of soft tissue volume. Aesthet Surg J. 2011; 31(1):95-109. 21239677","journal-title":"Aesthet Surg J"},{"issue":"1","key":"e_1_3_1_22_2","first-page":"44","article-title":"Treatment of tear trough deformity with hyaluronic acid gel filler","volume":"74","author":"Viana GA","year":"2011","unstructured":"Viana GA, , Osaki MH, , Cariello AJ, , Damasceno RW. Treatment of tear trough deformity with hyaluronic acid gel filler [in Portuguese]. Arq Bras Oftalmol. 2011; 74(1):44-47. 21670907","journal-title":"Arq Bras Oftalmol"},{"issue":"9","key":"e_1_3_1_23_2","first-page":"1094","article-title":"Brighter eyes: combined upper cheek and tear trough augmentation: a systematic approach utilizing two complementary hyaluronic acid fillers","volume":"11","author":"Tung R","year":"2012","unstructured":"Tung R, , Ruiz de Luzuriaga AM, , Park K, , Sato M, , Dubina M, , Alam M. Brighter eyes: combined upper cheek and tear trough augmentation: a systematic approach utilizing two complementary hyaluronic acid fillers. J Drugs Dermatol. 2012; 11(9):1094-1097. 23135653","journal-title":"J Drugs Dermatol"},{"issue":"1","key":"e_1_3_1_24_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/14764172.2013.854620","article-title":"Rejuvenation effects of hyaluronic acid injection on nasojugal groove: prospective randomized split face clinical controlled study","volume":"16","author":"Lim HK","year":"2014","unstructured":"Lim HK, , Suh DH, , Lee SJ, , Shin MK. Rejuvenation effects of hyaluronic acid injection on nasojugal groove: prospective randomized split face clinical controlled study. J Cosmet Laser Ther. 2014; 16(1):32-36. 24245880","journal-title":"J Cosmet Laser Ther"},{"issue":"1","key":"e_1_3_1_25_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/01676830.2017.1279641","article-title":"Tear trough rejuvenation: a safety evaluation of the treatment by a semi-cross-linked hyaluronic acid filler","volume":"36","author":"Berguiga M","year":"2017","unstructured":"Berguiga M, , Galatoire O. Tear trough rejuvenation: a safety evaluation of the treatment by a semi-cross-linked hyaluronic acid filler. Orbit. 2017; 36(1):22-26. 28121477","journal-title":"Orbit"}],"updated-by":[{"DOI":"10.1001\/jamafacial.2018.0679","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000}}],"container-title":["JAMA Facial Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1001\/jamafacial.2018.0230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1001\/jamafacial.2018.0230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1001\/jamafacial.2018.0230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:25:50Z","timestamp":1777443950000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1001\/jamafacial.2018.0230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1001\/jamafacial.2018.0230"],"URL":"https:\/\/doi.org\/10.1001\/jamafacial.2018.0230","relation":{},"ISSN":["2168-6076","2168-6092"],"issn-type":[{"value":"2168-6076","type":"print"},{"value":"2168-6092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}