{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:53:22Z","timestamp":1778658802551,"version":"3.51.4"},"reference-count":36,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Intern Med"],"published-print":{"date-parts":[[2018,7,1]]},"DOI":"10.1001\/jamainternmed.2018.0850","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T16:30:42Z","timestamp":1526920242000},"page":"913","source":"Crossref","is-referenced-by-count":23,"title":["Aldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure"],"prefix":"10.1001","volume":"178","author":[{"given":"Khagendra","family":"Dahal","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Hendrani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharan P.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, LRGHealthcare, University of New England, Laconia, New Hampshire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sampath","family":"Singireddy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Mina","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratap","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paari","family":"Dominic","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalgi","family":"Modi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","reference":[{"issue":"2","key":"ioi180021r1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC).","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"issue":"4","key":"ioi180021r2","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1016\/j.jacc.2012.11.019","article-title":"2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines.","volume":"61","author":"O\u2019Gara","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"ioi180021r3","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1016\/j.jacc.2014.08.037","article-title":"Short- and long-term cause of death in patients treated with primary PCI for STEMI.","volume":"64","author":"Pedersen","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"ioi180021r4","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.113.001878","article-title":"Pathological ventricular remodeling: mechanisms: part 1 of 2.","volume":"128","author":"Burchfield","year":"2013","journal-title":"Circulation"},{"issue":"20","key":"ioi180021r5","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1161\/01.CIR.99.20.2694","article-title":"Activation of cardiac aldosterone production in rat myocardial infarction: effect of angiotensin II receptor blockade and role in cardiac fibrosis.","volume":"99","author":"Silvestre","year":"1999","journal-title":"Circulation"},{"issue":"1","key":"ioi180021r6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.5847\/wjem.j.issn.1920-8642.2013.01.009","article-title":"Effect of spironolactone on cardiac remodeling after acute myocardial infarction.","volume":"4","author":"Wu","year":"2013","journal-title":"World J Emerg Med"},{"issue":"9","key":"ioi180021r7","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/CIRCULATIONAHA.113.001879","article-title":"Pathological ventricular remodeling: therapies: part 2 of 2.","volume":"128","author":"Xie","year":"2013","journal-title":"Circulation"},{"issue":"24","key":"ioi180021r8","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1161\/CIRCULATIONAHA.106.634626","article-title":"High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction.","volume":"114","author":"Beygui","year":"2006","journal-title":"Circulation"},{"issue":"4","key":"ioi180021r9","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.ahj.2008.12.013","article-title":"Aldosterone and long-term outcome after myocardial infarction: a substudy of the French nationwide observatoire sur la prise en charge hospitali\u00e8re, l\u2019evolution \u00e0 un an et les caract\u00e9ristiques de patients pr\u00e9sentant un infarctus du myocarde avec ou sans onde Q (OPERA) study.","volume":"157","author":"Beygui","year":"2009","journal-title":"Am Heart J"},{"issue":"1","key":"ioi180021r10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2459\/JCM.0b013e328364129c","article-title":"Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up.","volume":"15","author":"Mignano","year":"2014","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"14","key":"ioi180021r11","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"issue":"16","key":"ioi180021r12","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1016\/j.jacc.2016.02.033","article-title":"Early aldosterone blockade in acute myocardial infarction: the ALBATROSS randomized clinical trial.","volume":"67","author":"Beygui","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"ioi180021r13","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.ahj.2005.03.032","article-title":"Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarction.","volume":"150","author":"Di Pasquale","year":"2005","journal-title":"Am Heart J"},{"issue":"34","key":"ioi180021r14","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1093\/eurheartj\/ehu164","article-title":"Early eplerenone treatment in patients with acute ST-elevation myocardial infarction without heart failure: the Randomized Double-blind REMINDER Study.","volume":"35","author":"Montalescot","year":"2014","journal-title":"Eur Heart J"},{"issue":"7","key":"ioi180021r15","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-analyses: the PRISMA statement.","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"7521","key":"ioi180021r16","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1136\/bmj.331.7521.897","article-title":"Simultaneous comparison of multiple treatments: combining direct and indirect evidence.","volume":"331","author":"Caldwell","year":"2005","journal-title":"BMJ"},{"issue":"6","key":"ioi180021r17","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/sim.v34.6","article-title":"Predictive distributions for between-study heterogeneity and simple methods for their application in Bayesian meta-analysis.","volume":"34","author":"Turner","year":"2015","journal-title":"Stat Med"},{"issue":"3","key":"ioi180021r18","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1093\/ije\/dys041","article-title":"Predicting the extent of heterogeneity in meta-analysis, using empirical data from the Cochrane Database of Systematic Reviews.","volume":"41","author":"Turner","year":"2012","journal-title":"Int J Epidemiol"},{"issue":"4","key":"ioi180021r19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/10618600.1998.10474787","article-title":"General methods for monitoring convergence of iterative simulations.","volume":"7","author":"Brooks","year":"1998","journal-title":"J Comput Graph Stat"},{"key":"ioi180021r20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/2046-4053-3-110","article-title":"A Microsoft-Excel-based tool for running and critically appraising network meta-analyses: an overview and application of NetMetaXL.","volume":"3","author":"Brown","year":"2014","journal-title":"Syst Rev"},{"issue":"4","key":"ioi180021r21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/cdr.2013.31.issue-4","article-title":"Does spironolactone have a dose-dependent effect on left ventricular remodeling in patients with preserved left ventricular function after an acute myocardial infarction?","volume":"31","author":"Vatankulu","year":"2013","journal-title":"Cardiovasc Ther"},{"issue":"8","key":"ioi180021r22","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1097\/MCA.0b013e32833fd243","article-title":"The effects of spironolactone on atrial remodeling in patients with preserved left ventricular function after an acute myocardial infarction: a randomized follow-up study.","volume":"21","author":"Kayrak","year":"2010","journal-title":"Coron Artery Dis"},{"issue":"5","key":"ioi180021r23","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1080\/00365510902802278","article-title":"Effects of aldosterone blockade on left ventricular function and clinical status during acute myocardial infarction.","volume":"69","author":"Uzunhasan","year":"2009","journal-title":"Scand J Clin Lab Invest"},{"issue":"20","key":"ioi180021r24","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1161\/01.CIR.0000068340.96506.0F","article-title":"Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction.","volume":"107","author":"Hayashi","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"ioi180021r25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1067\/mhj.2001.111258","article-title":"Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction.","volume":"141","author":"Modena","year":"2001","journal-title":"Am Heart J"},{"issue":"2-3","key":"ioi180021r26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0167-5273(00)00425-3","article-title":"The combination ace-inhibitors plus canreonate in patients with anterior myocardial infarction: safety and tolerability study.","volume":"77","author":"Di Pasquale","year":"2001","journal-title":"Int J Cardiol"},{"issue":"5","key":"ioi180021r27","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/cpt.1977.21.issue-5","article-title":"Spironolactone and canrenoate-K: relative potency at steady state.","volume":"21","author":"Ramsay","year":"1977","journal-title":"Clin Pharmacol Ther"},{"issue":"9","key":"ioi180021r29","doi-asserted-by":"publisher","first-page":"e6226","DOI":"10.1097\/MD.0000000000006226","article-title":"Prognostic value of ejection fraction in patients admitted with acute coronary syndrome: a real world study.","volume":"96","author":"Perelshtein Brezinov","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"ioi180021r31","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1161\/01.CIR.0000138973.55605.38","article-title":"Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction.","volume":"110","author":"Perrier","year":"2004","journal-title":"Circulation"},{"issue":"23","key":"ioi180021r32","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1161\/CIRCULATIONAHA.104.503706","article-title":"Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias.","volume":"111","author":"Ouvrard-Pascaud","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"ioi180021r33","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1161\/HYPERTENSIONAHA.107.100941","article-title":"Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response.","volume":"51","author":"Fraccarollo","year":"2008","journal-title":"Hypertension"},{"issue":"8","key":"ioi180021r34","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S0735-1097(02)02173-3","article-title":"Hospital outcomes in patients presenting with congestive heart failure complicating acute myocardial infarction: a report from the Second National Registry of Myocardial Infarction (NRMI-2).","volume":"40","author":"Wu","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ioi180021r35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mayocpiqo.2017.05.004","article-title":"National trends in the incidence, management, and outcomes of heart failure complications in patients hospitalized for ST-segment elevation myocardial infarction.","volume":"1","author":"Agarwal","year":"2017","journal-title":"Mayo Clin Proc Innovations Quality & Outcomes"},{"issue":"5","key":"ioi180021r36","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/clc.22401","article-title":"Mineralocorticoid receptor antagonist pretreatment to MINIMISE reperfusion injury after ST-elevation myocardial infarction (the MINIMISE STEMI Trial): rationale and study design.","volume":"38","author":"Bulluck","year":"2015","journal-title":"Clin Cardiol"},{"key":"ioi180021r30","author":"Beygui","year":"2017"},{"key":"ioi180021r28","unstructured":"HigginsJPT, GreenS, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. London, UK: Cochrane Collaboration; 2011. http:\/\/training.cochrane.org\/handbook. Accessed April 11, 2018."}],"container-title":["JAMA Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2681656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T22:14:04Z","timestamp":1720304044000},"score":1,"resource":{"primary":{"URL":"http:\/\/archinte.jamanetwork.com\/article.aspx?doi=10.1001\/jamainternmed.2018.0850"}},"subtitle":["A Systematic Review and Meta-analysis"],"short-title":[],"issued":{"date-parts":[[2018,7,1]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamainternmed.2018.0850","relation":{},"ISSN":["2168-6106"],"issn-type":[{"value":"2168-6106","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,1]]}}}