{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:03:26Z","timestamp":1790737406346,"version":"4.1.0"},"reference-count":56,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Intern Med"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec id=\"ab-ioi230035-4\"><jats:title>Importance<\/jats:title><jats:p>People who survive hospitalization for COVID-19 are at risk for developing new cardiovascular, neurological, mental health, and inflammatory autoimmune conditions. It is unclear how posthospitalization risks for COVID-19 compare with those for other serious infectious illnesses.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230035-5\"><jats:title>Objective<\/jats:title><jats:p>To compare risks of incident cardiovascular, neurological, and mental health conditions and rheumatoid arthritis in 1 year following COVID-19 hospitalization against 3 comparator groups: prepandemic hospitalization for influenza and hospitalization for sepsis before and during the COVID-19 pandemic.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230035-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This population-based cohort study included all adults hospitalized for COVID-19 between April 1, 2020, and October 31, 2021, historical comparator groups of people hospitalized for influenza or sepsis, and a contemporary comparator group of people hospitalized for sepsis in Ontario, Canada.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230035-7\"><jats:title>Exposure<\/jats:title><jats:p>Hospitalization for COVID-19, influenza, or sepsis.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230035-8\"><jats:title>Main Outcome and Measures<\/jats:title><jats:p>New occurrence of 13 prespecified conditions, including cardiovascular, neurological, and mental health conditions and rheumatoid arthritis, within 1 year of hospitalization.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230035-9\"><jats:title>Results<\/jats:title><jats:p>Of 379\u202f366 included adults (median [IQR] age, 75 [63-85] years; 54% female), there were 26\u202f499 people who survived hospitalization for COVID-19, 299\u202f989 historical controls (17\u202f516 for influenza and 282\u202f473 for sepsis), and 52\u202f878 contemporary controls hospitalized for sepsis. Hospitalization for COVID-19 was associated with an increased 1-year risk of venous thromboembolic disease compared with influenza (adjusted hazard ratio, 1.77; 95% CI, 1.36-2.31) but with no increased risks of developing selected ischemic and nonischemic cerebrovascular and cardiovascular disorders, neurological disorders, rheumatoid arthritis, or mental health conditions compared with influenza or sepsis cohorts.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230035-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this cohort study, apart from an elevated risk of venous thromboembolism within 1 year, the burden of postacute medical and mental health conditions among those who survived hospitalization for COVID-19 was comparable with other acute infectious illnesses. This suggests that many of the postacute consequences of COVID-19 may be related to the severity of infectious illness necessitating hospitalization rather than being direct consequences of infection with SARS-CoV-2.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamainternmed.2023.2228","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T15:15:59Z","timestamp":1687274159000},"page":"806","source":"Crossref","is-referenced-by-count":50,"title":["Comparison of Medical and Mental Health Sequelae Following Hospitalization for COVID-19, Influenza, and Sepsis"],"prefix":"10.1001","volume":"183","author":[{"given":"Kieran L.","family":"Quinn","sequence":"first","affiliation":[{"name":"Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"ICES, Toronto and Ottawa, Ontario, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, 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