{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:07:27Z","timestamp":1786975647218,"version":"build-2736575974"},"reference-count":16,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Intern Med"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:sec id=\"ab-ioi230093-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>\n                      Despite a lack of effectiveness data in humans, tecovirimat was widely prescribed to people with HIV (PWH) with mpox during the 2022 mpox epidemic, particularly PWH with low CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell counts or severe mpox clinical manifestations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi230093-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate if PWH with mpox who were treated with tecovirimat within 7 days of symptom onset were less likely to have mpox disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi230093-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This cohort study included PWH diagnosed with mpox at 4 hospitals in Atlanta, Georgia, between June 1 and October 7, 2022. Patients were grouped according to whether they were treated with tecovirimat within 7 days of mpox symptom onset (early tecovirimat cohort) or they did not receive tecovirimat or received the drug 7 or more days after symptom onset (late or no tecovirimat cohort). Multivariable logistic regression models were used to identify factors associated with progression of mpox disease. The 2 cohorts were then matched 1:1 using propensity scores based on the identified factors, and mpox disease progression was compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi230093-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>Treatment with tecovirimat within 7 days of mpox symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi230093-8\">\n                    <jats:title>Main Outcome and Measures<\/jats:title>\n                    <jats:p>Progression of mpox disease, defined as the development of at least 1 severe mpox criterion established by the US Centers for Disease Control and Prevention, after symptom day 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi230093-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After propensity score matching, a total of 112 PWH were included in the analysis; 56 received tecovirimat within 7 days of mpox symptom onset (early tecovirimat group) and 56 were either treated later or did not receive tecovirimat (late or no tecovirimat group). In the early tecovirimat group, the median (IQR) age was 35 (30-42) years; 54 individuals (96.4%) were cisgender men, 46 (82.1%) were Black individuals, and 10 (17.9%) were individuals of other races (American Indian or Alaska Native, Asian, Native Hawaiian or Other Pacific Islander, or White) or unknown race. In the late or no tecovirimat group, the median (IQR) age was 36 (32-43) years; 54 (96.4%) were cisgender men, 49 (87.5%) were Black individuals, and 7 (12.5%) were individuals of other races or unknown race. Mpox disease progression occurred in 3 PWH (5.4%) in the early tecovirimat group and in 15 PWH (26.8%) in the late or no tecovirimat group (paired odds ratio, 13.00 [95% CI, 1.71-99.40];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi230093-10\">\n                    <jats:title>Conclusion and Relevance<\/jats:title>\n                    <jats:p>Results of this cohort study support starting tecovirimat in all PWH as soon as an mpox diagnosis is suspected. Additional research is warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamainternmed.2023.7696","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T12:30:53Z","timestamp":1704717053000},"page":"275","source":"Crossref","is-referenced-by-count":31,"title":["Early Tecovirimat Treatment for Mpox Disease Among People With HIV"],"prefix":"10.1001","volume":"184","author":[{"given":"Bruce","family":"Aldred","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Lyles","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Y.","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Gromer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"Atlanta Veterans Affairs Health Care System, Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Aldredge","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Workowski","sequence":"additional","affiliation":[{"name":"Division of Infectious 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Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandi N.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina A.","family":"Rebolledo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"},{"name":"Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Ly","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent C.","family":"Marconi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"Atlanta Veterans Affairs Health Care System, Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen F.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Kandiah","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aley","family":"Kalapila","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse T.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Hall","sequence":"additional","affiliation":[{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Colasanti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"},{"name":"Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"Atlanta Veterans Affairs Health Care System, Decatur, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria D.","family":"Cantos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"},{"name":"The Ponce Center, Grady Health System, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"4","key":"ioi230093r1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/infdis\/jiad034","article-title":"Clinical features, antiviral treatment, and patient outcomes: a systematic review and comparative analysis of the previous and the 2022 mpox outbreaks.","volume":"228","author":"Li","year":"2023","journal-title":"J Infect Dis"},{"issue":"1","key":"ioi230093r2","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3390\/pathogens12010146","article-title":"clinical characteristics of human mpox (monkeypox) in 2022: a systematic review and meta-analysis.","volume":"12","author":"Liu","year":"2023","journal-title":"Pathogens"},{"issue":"4","key":"ioi230093r3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/QAD.0000000000003449","article-title":"Characteristics and clinical manifestations of monkeypox among people with and without HIV in the United 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