{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:46:14Z","timestamp":1790721974574,"version":"4.1.0"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Intern Med"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec id=\"ab-ioi230104-4\"><jats:title>Importance<\/jats:title><jats:p>COVID-19 infection is associated with a high incidence of acute kidney injury (AKI). Although rapid kidney function decline has been reported in the first few months after COVID-19\u2212associated AKI (COVID-AKI), the longer-term association of COVID-AKI with kidney function remains unknown.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230104-5\"><jats:title>Objective<\/jats:title><jats:p>To assess long-term kidney outcomes of patients who had COVID-19\u2212associated AKI.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230104-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This was a retrospective longitudinal multicenter cohort study conducted in a large hospital system using electronic health records data on adult hospitalized patients with AKI and COVID-19 or other illnesses. Included patients were hospitalized during the COVID-19 pandemic (March 2020-June 2022), were screened for SARS-CoV-2, had AKI, and survived to discharge, or had been hospitalized during the 5 years before the pandemic (October 2016-January 2020), had a positive influenza A or B test result, had AKI, and survived to discharge. Patients were followed up for a maximum of 2 years after hospital discharge. Data analyses were performed from December 2022 to November 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230104-7\"><jats:title>Exposure<\/jats:title><jats:p>COVID-19 and influenza.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230104-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The primary outcome was major adverse kidney events (MAKE), defined as a composite of mortality and worsened kidney function (estimated glomerular filtration rate [eGFR] decline by \u226525% from discharge eGFR or kidney failure requiring dialysis). Multivariable time-to-event analyses were performed to compare MAKE between individuals with COVID-AKI and those who had AKI associated with other illnesses hospitalized during the same period. For further comparison, this outcome was assessed for a historic cohort of patients with influenza-associated AKI.<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230104-9\"><jats:title>Results<\/jats:title><jats:p>The study cohort included 9624 hospitalized patients (mean [SD] age, 69.0 [15.7] years; 4955 [51.5%] females) with AKI, including 987 patients with COVID-AKI, 276 with influenza-associated AKI, and 8361 with AKI associated with other illnesses (other-AKI). Compared with the other 2 groups, patients with COVID-19\u2212associated AKI were slightly younger in age, had a higher baseline eGFR, worse baseline comorbidity scores, higher markers of illness severity, and longer hospital stay. Compared with the other-AKI group, the COVID-AKI group had lower MAKE (adjusted hazard ratio [aHR], 0.67; 95% CI, 0.59-0.75) due to lower all-cause mortality (aHR, 0.31; 95% CI, 0.24-0.39) and lower rates of worsened kidney function (aHR, 0.78; 95% CI, 0.69-0.88).<\/jats:p><\/jats:sec><jats:sec id=\"ab-ioi230104-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The findings of this multicenter cohort study indicate that survivors of hospitalization with COVID-AKI experience lower rates of MAKE, long-term kidney function decline, and mortality compared with patients with AKI associated with other illnesses.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamainternmed.2023.8225","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T16:32:52Z","timestamp":1708965172000},"page":"414","source":"Crossref","is-referenced-by-count":53,"title":["COVID-19\u2212Associated Acute Kidney Injury and Longitudinal Kidney Outcomes"],"prefix":"10.1001","volume":"184","author":[{"given":"Abinet M.","family":"Aklilu","sequence":"first","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"},{"name":"Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Nugent","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"},{"name":"Section of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Coronel-Moreno","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashar","family":"Kadhim","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"},{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia C.","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle D.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Yasmin","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"},{"name":"Section of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis G.","family":"Moledina","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"},{"name":"Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Testani","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut"},{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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