{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:23:08Z","timestamp":1793013788062,"version":"4.5.0"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Intern Med"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:sec id=\"ab-ioi240088-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The optimal antiviral drug for treatment of nonsevere influenza remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi240088-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare effects of antiviral drugs for treating nonsevere influenza.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi240088-6\">\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>MEDLINE, Embase, CENTRAL, CINAHL, Global Health, Epistemonikos, and ClinicalTrials.gov were searched from database inception to September 20, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi240088-7\">\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>Randomized clinical trials comparing direct-acting influenza antiviral drugs to placebo, standard care, or another antiviral drug for treating people with nonsevere influenza.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi240088-8\">\n                    <jats:title>Data Extraction and Synthesis<\/jats:title>\n                    <jats:p>Paired reviewers independently performed data extraction and risk of bias assessment. A frequentist network meta-analysis was performed to summarize the evidence and the certainty of evidence was evaluated using the GRADE approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi240088-9\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Mortality, admission to hospital, admission to the intensive care unit, duration of hospitalization, time to alleviation of symptoms, emergence of resistance, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi240088-10\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 73 trials with 34\u202f332 participants proved eligible. Compared with standard care or placebo, all antiviral drugs had little or no effect on mortality for low-risk patients and high-risk patients (all high certainty). All antiviral drugs (no data for peramivir and amantadine) had little or no effect on hospital admission for low-risk patients (high certainty). For hospital admission in high-risk patients, oseltamivir (risk difference [RD], \u22120.4%; 95% CI, \u22121.0 to 0.4; high certainty) had little or no effect and baloxavir may have reduced risk (RD, \u22121.6%; 95% CI, \u22122.0 to 0.4; low certainty); all other drugs may have had little or uncertain effect. For time to alleviation of symptoms, baloxavir probably reduced symptom duration (mean difference [MD], \u22121.02 days; 95% CI, \u22121.41 to \u22120.63; moderate certainty); umifenovir may have reduced symptom duration (MD, \u22121.10 days; 95% CI, \u22121.57 to \u22120.63; low certainty); oseltamivir probably had no important effect (MD, \u22120.75 days; 95% CI, \u22120.93 to \u22120.57; moderate certainty). For adverse events related to treatment, baloxavir (RD, \u22123.2%; 95% CI, \u22125.2 to \u22120.6; high certainty) had few or no adverse events; oseltamivir (RD, 2.8%; 95% CI, 1.2 to 4.8; moderate certainty) probably increased adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi240088-11\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis found that baloxavir probably reduced risk of hospital admission for high-risk patients and may reduce time to alleviation of symptoms, without increasing adverse events related to treatment in patients with nonsevere influenza. All other antiviral drugs either probably have little or no effect, or uncertain effects on patient-important outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamainternmed.2024.7193","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:01:03Z","timestamp":1736766063000},"page":"293","source":"Crossref","is-referenced-by-count":51,"title":["Antiviral Medications for Treatment of Nonsevere Influenza"],"prefix":"10.1001","volume":"185","author":[{"given":"Ya","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Healthcare Big Data Research Institute, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"},{"name":"Department of Health Research Methods, 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