{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:42:27Z","timestamp":1793338947234,"version":"4.5.0"},"reference-count":21,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Intern Med"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec id=\"ab-ioi250075-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Automated external defibrillators (AEDs) have the potential to save lives when used during cardiac arrest. While most cardiac arrests occur at home, there is limited evidence for AED use in private homes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi250075-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether AEDs in private homes are effective and cost-effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi250075-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This cohort study used observational data from the Cardiac Arrest Registry to Enhance Survival in the US from January 2017 to December 2024 to determine the effectiveness of AEDs when used for cardiac arrests in private homes. A difference-in-difference approach was used to determine the causal relationship between AED application and survival to hospital discharge. A decision-analytic model was then created to evaluate the cost-effectiveness of purchasing an AED in a private home in the US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi250075-7\">\n                    <jats:title>Exposure<\/jats:title>\n                    <jats:p>Application of an AED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi250075-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Survival to hospital discharge and cost-effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi250075-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 582\u202f536 included patients, 359\u202f809 (61.8%) were male, and the median (IQR) age was 65 (52-76) years. Survival was better with AED application compared with no AED application in patients with a shockable rhythm (risk ratio, 1.26; 95% CI, 1.01-1.57) but not in those with a nonshockable rhythm (risk ratio, 1.00; 95% CI, 0.68-1.46). Results were consistent in the difference-in-difference analysis. The incremental cost-effectiveness ratio for an AED in a private home was $4\u202f481\u202f659 per quality-adjusted life-year. At a cost-effectiveness threshold of $200\u202f000 per quality-adjusted life-year, AEDs in private homes would be considered cost-effective at a yearly cardiac arrest incidence per person above 1.3% or at an AED cost less than $65 (not including bystander training cost).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-ioi250075-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>In this study, AEDs in private homes were effective at improving outcomes for patients with cardiac arrest and a shockable rhythm. Given the relative rarity of cardiac arrest at a given home, general purchase of AEDs for individual private homes cannot be considered cost-effective at the current pricing of AEDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamainternmed.2025.6123","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T09:30:18Z","timestamp":1761384618000},"page":"37","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes"],"prefix":"10.1001","volume":"186","author":[{"given":"Lars W.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Prehospital Emergency Medical Services, Central Denmark Region, Aarhus, Denmark"},{"name":"Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Folke","sequence":"additional","affiliation":[{"name":"Capital Region Emergency Medical Services, Copenhagen University, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"},{"name":"The Prehospital Center, Region Zealand, N\u00e6stved, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kunst","sequence":"additional","affiliation":[{"name":"Centre for Health Economics, University of York, York, United Kingdom"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University School of Medicine, New Haven, Connecticut"},{"name":"Public Health Modeling Unit, Yale University School of Public Health, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijntje Willemijn","family":"Dijk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands"},{"name":"Department of Radiology, Elisabeth-Tweesteden Ziekenhuis, Tilburg, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Granfeldt","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Caulley","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Ottawa Hospital, Ottawa, Ontario, Canada"},{"name":"Otolaryngology-Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","reference":[{"issue":"8","key":"ioi250075r1","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics\u20142023 update: a report from the American Heart Association.","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"ioi250075r2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.resuscitation.2020.02.044","article-title":"Out-of-hospital cardiac arrest across the world: first report from the International Liaison Committee on Resuscitation 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