{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:44:16Z","timestamp":1782182656084,"version":"3.54.5"},"reference-count":111,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Intern Med"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec id=\"ab-irv260001-1\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Orthostatic hypotension is a common but underrecognized condition that increases with age and is associated with a lower quality of life, falls, and increased mortality. The frequent coexistence of supine hypertension and postprandial hypotension with orthostatic hypotension makes it a challenging condition to manage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-irv260001-2\">\n                    <jats:title>Observations<\/jats:title>\n                    <jats:p>Testing for orthostatic hypotension should be done in patients with orthostatic symptoms (eg, vision changes and dizziness that occur only when upright and improve when seated or lying down), as well as asymptomatic patients in high-risk groups such as adults with frailty who are older than 70 years, individuals with neurodegenerative or autonomic disorders, and patients with unexplained falls. Patients with orthostatic hypotension should be screened for postprandial hypotension and supine hypertension to inform the treatment approach. Nonpharmacological strategies, such as medication review, increased salt and fluid intake, compression garments, and behavioral modifications, serve as fundamental approaches to treat orthostatic hypotension. Midodrine and droxidopa are the only US Food and Drug Administration\u2013approved medications for orthostatic hypotension, but other medications (eg, fludrocortisone, atomoxetine, pyridostigmine) are used off label as part of an individualized treatment plan. Treatment targets in orthostatic hypotension are focused not on blood pressure measurements but on symptom relief and fall prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-irv260001-3\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>All patients with orthostatic symptoms\u2014along with other select patient groups\u2014should be evaluated for orthostatic hypotension. Nonpharmacological treatments are first line, and medication decisions should be tailored based on clinical presentation and relevant comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamainternmed.2026.0284","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T15:00:52Z","timestamp":1775487652000},"page":"744","source":"Crossref","is-referenced-by-count":4,"title":["Management of Orthostatic Hypotension"],"prefix":"10.1001","volume":"186","author":[{"given":"David","family":"Moloney","sequence":"first","affiliation":[{"name":"Vanderbilt Autonomic Dysfunction Center, Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Youssef","sequence":"additional","affiliation":[{"name":"Vanderbilt Autonomic Dysfunction Center, Division of Genetic Medicine and Clinical 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