{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:15:01Z","timestamp":1793196901195,"version":"4.5.0"},"reference-count":37,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.11426","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T15:00:47Z","timestamp":1568818847000},"page":"e1911426","source":"Crossref","is-referenced-by-count":96,"title":["Association of Timing of Adverse Childhood Experiences and Caregiver Support With Regionally Specific Brain Development in Adolescents"],"prefix":"10.1001","volume":"2","author":[{"given":"Joan L.","family":"Luby","sequence":"first","affiliation":[{"name":"Department of Psychiatry (Child), School of Medicine, Washington University in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Tillman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna M.","family":"Barch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Washington University in St Louis, St Louis, Missouri"},{"name":"Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"issue":"1","key":"zoi190446r1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/npp.2015.252","article-title":"Early adverse experiences and the developing brain.","volume":"41","author":"Bick","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"zoi190446r2","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1001\/jamapediatrics.2015.1475","article-title":"Association of child poverty, brain development, and academic achievement.","volume":"169","author":"Hair","year":"2015","journal-title":"JAMA Pediatr"},{"issue":"12","key":"zoi190446r3","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1001\/jamapediatrics.2013.3139","article-title":"The effects of poverty on childhood brain development: the mediating effect of caregiving and stressful life events.","volume":"167","author":"Luby","year":"2013","journal-title":"JAMA Pediatr"},{"issue":"4","key":"zoi190446r4","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3075","article-title":"State of the art review: poverty and the developing brain.","volume":"137","author":"Johnson","year":"2016","journal-title":"Pediatrics"},{"issue":"2","key":"zoi190446r5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/desc.2015.18.issue-2","article-title":"Parent support is less effective in buffering cortisol stress reactivity for adolescents compared to children.","volume":"18","author":"Hostinar","year":"2015","journal-title":"Dev Sci"},{"issue":"10","key":"zoi190446r6","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nrn.2016.111","article-title":"The effects of childhood maltreatment on brain structure, function and connectivity.","volume":"17","author":"Teicher","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"zoi190446r7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.neuroimage.2017.12.055","article-title":"Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus.","volume":"169","author":"Teicher","year":"2018","journal-title":"Neuroimage"},{"issue":"2","key":"zoi190446r8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1177\/1077559505275116","article-title":"The psychobiology of neglect.","volume":"10","author":"De Bellis","year":"2005","journal-title":"Child Maltreat"},{"issue":"8","key":"zoi190446r9","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1001\/jamapsychiatry.2017.1558","article-title":"Role of positive parenting in the association between neighborhood social disadvantage and brain development across adolescence.","volume":"74","author":"Whittle","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"4","key":"zoi190446r10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.biopsych.2014.04.020","article-title":"Behavioral problems after early life stress: contributions of the hippocampus and amygdala.","volume":"77","author":"Hanson","year":"2015","journal-title":"Biol Psychiatry"},{"issue":"4","key":"zoi190446r11","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.biopsych.2009.10.017","article-title":"Hippocampal changes associated with early-life adversity and vulnerability to depression.","volume":"67","author":"Rao","year":"2010","journal-title":"Biol Psychiatry"},{"issue":"12","key":"zoi190446r12","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1001\/archpediatrics.2011.565","article-title":"Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment.","volume":"165","author":"Edmiston","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"zoi190446r13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1093\/jpepsy\/jsp112","article-title":"Reduced hippocampal activity in youth with posttraumatic stress symptoms: an fMRI study.","volume":"35","author":"Carri\u00f3n","year":"2010","journal-title":"J Pediatr Psychol"},{"issue":"5","key":"zoi190446r14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216338","article-title":"Sociodemographic disparities in corticolimbic structures.","volume":"14","author":"Shaked","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"zoi190446r15","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1523\/JNEUROSCI.1808-18.2018","article-title":"Longitudinally mapping childhood socioeconomic status associations with cortical and subcortical morphology.","volume":"39","author":"McDermott","year":"2019","journal-title":"J Neurosci"},{"issue":"8","key":"zoi190446r16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072604","article-title":"Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis.","volume":"8","author":"Hsieh","year":"2013","journal-title":"PLoS One"},{"key":"zoi190446r17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fnhum.2012.00052","article-title":"Neuroimaging of child abuse: a critical review.","volume":"6","author":"Hart","year":"2012","journal-title":"Front Hum Neurosci"},{"issue":"1","key":"zoi190446r18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3758\/s13415-015-0371-6","article-title":"Regional gray matter volume mediates the relationship between family socioeconomic status and depression-related trait in a young healthy sample.","volume":"16","author":"Yang","year":"2016","journal-title":"Cogn Affect Behav Neurosci"},{"issue":"11","key":"zoi190446r19","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.biopsych.2013.06.020","article-title":"Cortical thickness, surface area, and gyrification abnormalities in children exposed to maltreatment: neural markers of vulnerability?","volume":"74","author":"Kelly","year":"2013","journal-title":"Biol Psychiatry"},{"issue":"4","key":"zoi190446r20","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1111\/desc.2012.15.issue-4","article-title":"Neural correlates of socioeconomic status in the developing human brain.","volume":"15","author":"Noble","year":"2012","journal-title":"Dev Sci"},{"issue":"20","key":"zoi190446r21","doi-asserted-by":"publisher","first-page":"5742","DOI":"10.1073\/pnas.1601443113","article-title":"Preschool is a sensitive period for the influence of maternal support on the trajectory of hippocampal development.","volume":"113","author":"Luby","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"zoi190446r22","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1073\/pnas.1118003109","article-title":"Maternal support in early childhood predicts larger hippocampal volumes at school age.","volume":"109","author":"Luby","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"zoi190446r23","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jaac.2013.01.011","article-title":"Treatment of anxiety and depression in the preschool period.","volume":"52","author":"Luby","year":"2013","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"7","key":"zoi190446r24","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1177\/0956797619847989","article-title":"The protective effects of supportive parenting on the relationship between adolescent poverty and resting-state functional brain connectivity during adulthood.","volume":"30","author":"Brody","year":"2019","journal-title":"Psychol Sci"},{"issue":"4","key":"zoi190446r27","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1017\/S003329170003498X","article-title":"The Child and Adolescent Psychiatric Assessment (CAPA).","volume":"25","author":"Angold","year":"1995","journal-title":"Psychol Med"},{"issue":"1","key":"zoi190446r29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1001\/jamapsychiatry.2015.2356","article-title":"Early childhood depression and alterations in the trajectory of gray matter maturation in middle childhood and early adolescence.","volume":"73","author":"Luby","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"7","key":"zoi190446r30","doi-asserted-by":"publisher","first-page":"e154","DOI":"10.1515\/cclm-2016-0727","article-title":"Towards a random-access LC-MS\/MS model for busulfan analysis.","volume":"55","author":"Peake","year":"2017","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"zoi190446r32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1080\/14616730701455395","article-title":"Depressed and healthy preschoolers\u2019 internal representations of their mothers\u2019 caregiving: associations with observed caregiving behaviors one year later.","volume":"9","author":"Belden","year":"2007","journal-title":"Attach Hum Dev"},{"issue":"9","key":"zoi190446r33","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/nn.4361","article-title":"The Human Connectome Project\u2019s neuroimaging approach.","volume":"19","author":"Glasser","year":"2016","journal-title":"Nat Neurosci"},{"issue":"4","key":"zoi190446r34","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.neuroimage.2010.07.020","article-title":"Highly accurate inverse consistent registration: a robust approach.","volume":"53","author":"Reuter","year":"2010","journal-title":"Neuroimage"},{"issue":"1","key":"zoi190446r35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroimage.2010.06.010","article-title":"Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature.","volume":"53","author":"Destrieux","year":"2010","journal-title":"Neuroimage"},{"issue":"6","key":"zoi190446r36","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1046\/j.0956-7976.2003.psci_1475.x","article-title":"Socioeconomic status modifies heritability of IQ in young children.","volume":"14","author":"Turkheimer","year":"2003","journal-title":"Psychol Sci"},{"issue":"1","key":"zoi190446r37","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/desc.2009.13.issue-1","article-title":"Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation.","volume":"13","author":"Tottenham","year":"2010","journal-title":"Dev Sci"},{"key":"zoi190446r25","volume-title":"Brain Development","author":"Bangalore","year":"2009"},{"key":"zoi190446r26","volume-title":"Preschool Age Psychiatric Assessment (PAPA): Version 1.1","author":"Egger","year":"1999"},{"key":"zoi190446r28","volume-title":"Manual for the Family Interview for Genetic Studies (FIGS)","author":"Maxwell","year":"1992"},{"key":"zoi190446r31","volume-title":"The Emotion Reactivity Questionnaire","author":"Belden","year":"2005"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2751389\/luby_2019_oi_190446.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T15:00:50Z","timestamp":1568818850000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2751389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,4]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.11426","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]}}}