{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:25:10Z","timestamp":1790799910215,"version":"4.1.0"},"reference-count":59,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.14996","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T17:49:15Z","timestamp":1573235355000},"page":"e1914996","source":"Crossref","is-referenced-by-count":39,"title":["Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants"],"prefix":"10.1001","volume":"2","author":[{"given":"Maya","family":"Heath","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Neonatology, Louisiana State University School of Medicine, Children\u2019s Hospital of New Orleans, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine and Health Sciences Center, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeromeh","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Louisiana State University School of Medicine, Children\u2019s Hospital of New Orleans, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Porcha","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine and Health Sciences Center, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Linneman","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis Children\u2019s Hospital, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Gong","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis Children\u2019s Hospital, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Barkemeyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Louisiana State University School of Medicine, Children\u2019s Hospital of New Orleans, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhide","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Louisiana State University School of Public Health, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misty","family":"Good","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis Children\u2019s Hospital, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duna","family":"Penn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Louisiana State University School of Medicine, Children\u2019s Hospital of New Orleans, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine and Health Sciences Center, New Orleans"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"issue":"9543","key":"zoi190576r1","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/S0140-6736(06)69525-1","article-title":"Necrotising enterocolitis.","volume":"368","author":"Lin","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"zoi190576r2","doi-asserted-by":"publisher","first-page":"e298","DOI":"10.1542\/peds.2011-2022","article-title":"Incidence and timing of presentation of necrotizing enterocolitis in preterm infants.","volume":"129","author":"Yee","year":"2012","journal-title":"Pediatrics"},{"issue":"5 Pt 2","key":"zoi190576r3","doi-asserted-by":"publisher","first-page":"91R","DOI":"10.1203\/PDR.0b013e31819dba7d","article-title":"Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention?","volume":"65","author":"Young","year":"2009","journal-title":"Pediatr Res"},{"issue":"12","key":"zoi190576r4","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1053\/jpsu.2002.36696","article-title":"Surgical decision making in necrotizing enterocolitis and focal intestinal perforation: predictive value of radiologic findings.","volume":"37","author":"Tam","year":"2002","journal-title":"J Pediatr Surg"},{"issue":"6","key":"zoi190576r5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s004310100757","article-title":"Colonic pneumatosis intestinalis in preterm infants: different to necrotising enterocolitis with a more benign course?","volume":"160","author":"Hoehn","year":"2001","journal-title":"Eur J Pediatr"},{"issue":"1","key":"zoi190576r6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1542\/peds.66.1.68","article-title":"Interobserver variability in the radiographic diagnosis of necrotizing enterocolitis.","volume":"66","author":"Mata","year":"1980","journal-title":"Pediatrics"},{"issue":"11","key":"zoi190576r7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1177\/000992289903801102","article-title":"Observer variability in interpretation of abdominal radiographs of infants with suspected necrotizing enterocolitis.","volume":"38","author":"Rehan","year":"1999","journal-title":"Clin Pediatr (Phila)"},{"issue":"1","key":"zoi190576r8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/ppe.2004.18.issue-1","article-title":"Inter-observer reliability of radiological signs of necrotising enterocolitis in a population of high-risk newborns.","volume":"18","author":"Di Napoli","year":"2004","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"7","key":"zoi190576r9","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1007\/s00268-009-0074-7","article-title":"Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia.","volume":"33","author":"Evennett","year":"2009","journal-title":"World J Surg"},{"issue":"6","key":"zoi190576r10","doi-asserted-by":"publisher","first-page":"e120","DOI":"10.1097\/MPG.0000000000001588","article-title":"Serum markers of necrotizing enterocolitis: a systematic review.","volume":"65","author":"Terrin","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"zoi190576r11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jpeds.2017.05.075","article-title":"The microbiome and biomarkers for necrotizing enterocolitis: are we any closer to prediction?","volume":"189","author":"Rusconi","year":"2017","journal-title":"J Pediatr"},{"issue":"22","key":"zoi190576r12","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1080\/14767058.2017.1361925","article-title":"Biomarkers of necrotizing enterocolitis: a review of literature.","volume":"31","author":"Garg","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"4","key":"zoi190576r13","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/S0022-3476(05)82418-7","article-title":"Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates.","volume":"119","author":"Uauy","year":"1991","journal-title":"J Pediatr"},{"issue":"2 Pt 1","key":"zoi190576r14","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1542\/peds.110.2.285","article-title":"Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network.","volume":"110","author":"Stoll","year":"2002","journal-title":"Pediatrics"},{"issue":"3","key":"zoi190576r15","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1128\/CMR.17.3.638-680.2004","article-title":"Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants.","volume":"17","author":"Kaufman","year":"2004","journal-title":"Clin Microbiol Rev"},{"issue":"12","key":"zoi190576r16","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00383-005-1539-x","article-title":"Neonatal gut injury and infection rate: impact of surgical debridement on outcome.","volume":"21","author":"Sharma","year":"2005","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"zoi190576r17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jpeds.2011.06.034","article-title":"Bloodstream infections in very low birth weight infants with intestinal failure.","volume":"160","author":"Cole","year":"2012","journal-title":"J Pediatr"},{"issue":"3","key":"zoi190576r18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis.","volume":"364","author":"Neu","year":"2011","journal-title":"N Engl J Med"},{"issue":"3","key":"zoi190576r19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017776","article-title":"The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response.","volume":"6","author":"Nanthakumar","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"zoi190576r20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020647","article-title":"Fecal microbiota in premature infants prior to necrotizing enterocolitis.","volume":"6","author":"Mai","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"zoi190576r21","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1074\/mcp.M113.029967","article-title":"Host-centric proteomics of stool: a novel strategy focused on intestinal responses to the gut microbiota.","volume":"12","author":"Lichtman","year":"2013","journal-title":"Mol Cell Proteomics"},{"issue":"7","key":"zoi190576r22","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.cub.2012.02.022","article-title":"Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions.","volume":"22","author":"Shifrin","year":"2012","journal-title":"Curr Biol"},{"issue":"5","key":"zoi190576r23","doi-asserted-by":"publisher","first-page":"460","DOI":"10.4161\/gmic.21247","article-title":"Ready\u2026aim\u2026fire into the lumen: a new role for enterocyte microvilli in gut host defense.","volume":"3","author":"Shifrin","year":"2012","journal-title":"Gut Microbes"},{"issue":"11","key":"zoi190576r24","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012799","article-title":"STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration.","volume":"6","author":"Cohen","year":"2016","journal-title":"BMJ Open"},{"issue":"4","key":"zoi190576r25","first-page":"85","article-title":"STARD 2015: updated reporting guidelines for all diagnostic accuracy studies.","volume":"4","author":"Bossuyt","year":"2016","journal-title":"Ann Transl Med"},{"issue":"5","key":"zoi190576r26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1056\/NEJM197802022980519","article-title":"Neonatal necrotizing enterocolitis.","volume":"298","author":"Bell","year":"1978","journal-title":"N Engl J Med"},{"issue":"6","key":"zoi190576r27","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/jp.2014.37","article-title":"Discrimination of GutCheck(NEC): a clinical risk index for necrotizing enterocolitis.","volume":"34","author":"Gephart","year":"2014","journal-title":"J Perinatol"},{"issue":"3","key":"zoi190576r28","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1001\/jamapediatrics.2016.3633","article-title":"Development of a gestational age-specific case definition for neonatal necrotizing enterocolitis.","volume":"171","author":"Battersby","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"1","key":"zoi190576r29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/j.sempedsurg.2017.11.002","article-title":"Changing the paradigm of defining, detecting, and diagnosing NEC: perspectives on Bell\u2019s stages and biomarkers for NEC.","volume":"27","author":"Gephart","year":"2018","journal-title":"Semin Pediatr Surg"},{"issue":"1","key":"zoi190576r30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040018","article-title":"Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis.","volume":"4","author":"Buhimschi","year":"2007","journal-title":"PLoS Med"},{"issue":"3","key":"zoi190576r31","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1203\/01.pdr.0000252439.48564.37","article-title":"Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate.","volume":"61","author":"Buhimschi","year":"2007","journal-title":"Pediatr Res"},{"issue":"5","key":"zoi190576r32","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.cell.2014.11.016","article-title":"Credibility and reproducibility.","volume":"159","author":"Marcus","year":"2014","journal-title":"Cell"},{"key":"zoi190576r33","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/198685b0","article-title":"L-phenylalanine: an organ specific, stereospecific inhibitor of human intestinal alkaline phosphatase.","volume":"198","author":"Fishman","year":"1963","journal-title":"Nature"},{"issue":"3","key":"zoi190576r34","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1042\/bj1160543","article-title":"Inhibition of alkaline phosphatase by L-phenylalanine.","volume":"116","author":"Fernley","year":"1970","journal-title":"Biochem J"},{"issue":"1","key":"zoi190576r35","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.chom.2012.11.009","article-title":"An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection.","volume":"13","author":"Jensen","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"287","key":"zoi190576r36","doi-asserted-by":"publisher","first-page":"rs13","DOI":"10.1126\/scisignal.2003624","article-title":"Simultaneous profiling of 194 distinct receptor transcripts in human cells.","volume":"6","author":"Kang","year":"2013","journal-title":"Sci Signal"},{"issue":"3","key":"zoi190576r37","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1074\/mcp.O112.024059","article-title":"A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts.","volume":"12","author":"Bose","year":"2013","journal-title":"Mol Cell Proteomics"},{"issue":"9","key":"zoi190576r38","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"zoi190576r39","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0003-2697(81)90281-5","article-title":"\u201cWestern blotting\u201d: electrophoretic transfer of proteins from sodium dodecyl sulfate\u2013polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.","volume":"112","author":"Burnette","year":"1981","journal-title":"Anal Biochem"},{"issue":"1","key":"zoi190576r40","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0022-1759(85)90132-2","article-title":"Different blocking agents cause variation in the immunologic detection of proteins transferred to nitrocellulose membranes.","volume":"81","author":"Spinola","year":"1985","journal-title":"J Immunol Methods"},{"issue":"2","key":"zoi190576r41","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.cmpb.2008.03.001","article-title":"Sample size and power calculations based on generalized linear mixed models with correlated binary outcomes.","volume":"91","author":"Dang","year":"2008","journal-title":"Comput Methods Programs Biomed"},{"issue":"2","key":"zoi190576r42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/MOP.0000000000000315","article-title":"Defining neonatal sepsis.","volume":"28","author":"Wynn","year":"2016","journal-title":"Curr Opin Pediatr"},{"issue":"4","key":"zoi190576r43","doi-asserted-by":"publisher","first-page":"943","DOI":"10.21037\/jtd","article-title":"SIRS, qSOFA and new sepsis definition.","volume":"9","author":"Marik","year":"2017","journal-title":"J Thorac Dis"},{"issue":"3","key":"zoi190576r44","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1542\/peds.2004-0569","article-title":"Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis.","volume":"115","author":"Hintz","year":"2005","journal-title":"Pediatrics"},{"issue":"10","key":"zoi190576r45","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1136\/gut.2007.128934","article-title":"Urine based detection of intestinal mucosal cell damage in neonates with suspected necrotising enterocolitis.","volume":"56","author":"Derikx","year":"2007","journal-title":"Gut"},{"issue":"1-2","key":"zoi190576r46","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1023\/A:1020508420058","article-title":"Plasma concentration of intestinal- and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates.","volume":"239","author":"Guthmann","year":"2002","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"zoi190576r47","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1136\/gutjnl-2013-305130","article-title":"A novel urine peptide biomarker-based algorithm for the prognosis of necrotising enterocolitis in human infants.","volume":"63","author":"Sylvester","year":"2014","journal-title":"Gut"},{"issue":"6","key":"zoi190576r48","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1097\/SLA.0b013e3181d778c4","article-title":"Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis.","volume":"251","author":"Thuijls","year":"2010","journal-title":"Ann Surg"},{"issue":"3","key":"zoi190576r49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1203\/PDR.0b013e3182093280","article-title":"New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond.","volume":"69","author":"Afrazi","year":"2011","journal-title":"Pediatr Res"},{"issue":"4","key":"zoi190576r50","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1542\/peds.2009-3149","article-title":"Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis.","volume":"125","author":"Morowitz","year":"2010","journal-title":"Pediatrics"},{"issue":"3","key":"zoi190576r51","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1053\/j.gastro.2012.05.053","article-title":"Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.","volume":"143","author":"Sodhi","year":"2012","journal-title":"Gastroenterology"},{"issue":"11","key":"zoi190576r52","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.1073\/pnas.97.11.6043","article-title":"Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis.","volume":"97","author":"Nanthakumar","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"zoi190576r53","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1067\/mpd.2001.110132","article-title":"Platelet-activating factor in infants at risk for necrotizing enterocolitis.","volume":"138","author":"Rabinowitz","year":"2001","journal-title":"J Pediatr"},{"issue":"5","key":"zoi190576r54","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.jpeds.2010.04.075","article-title":"Inter-alpha inhibitor protein level in neonates predicts necrotizing enterocolitis.","volume":"157","author":"Chaaban","year":"2010","journal-title":"J Pediatr"},{"issue":"4","key":"zoi190576r55","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.jpedsurg.2009.09.024","article-title":"Urinary intestinal fatty acid-binding protein concentration predicts extent of disease in necrotizing enterocolitis.","volume":"45","author":"Evennett","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"5","key":"zoi190576r56","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1542\/peds.2004-1806","article-title":"C-reactive protein in the diagnosis, management, and prognosis of neonatal necrotizing enterocolitis.","volume":"116","author":"Pourcyrous","year":"2005","journal-title":"Pediatrics"},{"issue":"4","key":"zoi190576r57","first-page":"145","article-title":"Mapping the new world of necrotizing enterocolitis (NEC): review and opinion.","volume":"2","author":"Gordon","year":"2012","journal-title":"EJ Neonatol Res"},{"issue":"2","key":"zoi190576r58","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jpedsurg.2013.11.037","article-title":"The relationship between reticulated platelets, intestinal alkaline phosphatase, and necrotizing enterocolitis.","volume":"49","author":"Kampanatkosol","year":"2014","journal-title":"J Pediatr Surg"},{"issue":"7","key":"zoi190576r59","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1136\/jcp.46.7.654","article-title":"Plasma intestinal alkaline phosphatase isoenzymes in neonates with bowel necrosis.","volume":"46","author":"McLachlan","year":"1993","journal-title":"J Clin Pathol"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2754257\/heath_2019_oi_190576.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T04:39:15Z","timestamp":1664858355000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2754257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.14996","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]}}}