{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:40:50Z","timestamp":1780648850057,"version":"3.54.1"},"reference-count":55,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.15628","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:43:45Z","timestamp":1573818225000},"page":"e1915628","source":"Crossref","is-referenced-by-count":27,"title":["Association of Timing of Plasma Transfusion With Adverse Maternal Outcomes in Women With Persistent Postpartum Hemorrhage"],"prefix":"10.1001","volume":"2","author":[{"given":"Dacia D. C. A.","family":"Henriquez","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Jon J van Rood Center for Clinical Transfusion Research, Sanquin-Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Caram-Deelder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Jon J van Rood Center for Clinical Transfusion Research, Sanquin-Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"le Cessie","sequence":"additional","affiliation":[{"name":"Jon J van Rood Center for Clinical Transfusion Research, Sanquin-Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost J.","family":"Zwart","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Deventer Hospital, Deventer, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos J. M.","family":"van Roosmalen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Athena Institute, Vrije Universiteit, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen C. J.","family":"Eikenboom","sequence":"additional","affiliation":[{"name":"Division of Thrombosis and Hemostasis, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"So-Osman","sequence":"additional","affiliation":[{"name":"Sanquin Blood Bank, Unit Transfusion Medicine, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo M. G.","family":"van de Watering","sequence":"additional","affiliation":[{"name":"Sanquin Blood Bank, Unit Transfusion Medicine, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap Jan","family":"Zwaginga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankie W. M. M.","family":"Koopman-van Gemert","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Albert Schweitzer Hospital, Dordrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty W. M.","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Department of Obstetrics, Birth Center Wilhelmina\u2019s Children Hospital, Division Woman and Baby, University Medical Centre Utrecht, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna G.","family":"van der Bom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands"},{"name":"Jon J van Rood Center for Clinical Transfusion Research, Sanquin-Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the TeMpOH-1 Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"issue":"6","key":"zoi190593r1","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: a WHO systematic analysis.","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"2","key":"zoi190593r2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s00134-009-1707-x","article-title":"Obstetric intensive care unit admission: a 2-year nationwide population-based cohort study.","volume":"36","author":"Zwart","year":"2010","journal-title":"Intensive Care Med"},{"issue":"4","key":"zoi190593r3","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1097\/AOG.0000000000000173","article-title":"Frequency of and factors associated with severe maternal morbidity.","volume":"123","author":"Grobman","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"10","key":"zoi190593r4","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1111\/bjo.2008.115.issue-10","article-title":"Prevalence and risk factors of severe obstetric haemorrhage.","volume":"115","author":"Al-Zirqi","year":"2008","journal-title":"BJOG"},{"issue":"6","key":"zoi190593r5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/bjo.2007.114.issue-6","article-title":"Investigation of an increase in postpartum haemorrhage in Canada.","volume":"114","author":"Joseph","year":"2007","journal-title":"BJOG"},{"issue":"1","key":"zoi190593r6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S1701-2163(15)30680-0","article-title":"Temporal trends in postpartum hemorrhage and severe postpartum hemorrhage in Canada from 2003 to 2010.","volume":"36","author":"Mehrabadi","year":"2014","journal-title":"J Obstet Gynaecol Can"},{"key":"zoi190593r7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2393-9-7","article-title":"Trends in adverse maternal outcomes during childbirth: a population-based study of severe maternal morbidity.","volume":"9","author":"Roberts","year":"2009","journal-title":"BMC Pregnancy Childbirth"},{"issue":"7","key":"zoi190593r8","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1111\/trf.2014.54.issue-7","article-title":"Evaluation and management of postpartum hemorrhage: consensus from an international expert panel.","volume":"54","author":"Abdul-Kadir","year":"2014","journal-title":"Transfusion"},{"issue":"3","key":"zoi190593r9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1055\/s-0032-1302441","article-title":"Prohemostatic interventions in obstetric hemorrhage.","volume":"38","author":"Bonnet","year":"2012","journal-title":"Semin Thromb Hemost"},{"issue":"7","key":"zoi190593r10","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1055\/s-0036-1593417","article-title":"Management of Coagulopathy in Postpartum Hemorrhage.","volume":"42","author":"James","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"zoi190593r11","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1002\/ajh.23156","article-title":"Postpartum hemorrhage: when uterotonics and sutures fail.","volume":"87","author":"James","year":"2012","journal-title":"Am J Hematol"},{"issue":"8","key":"zoi190593r12","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1111\/jth.2011.9.issue-8","article-title":"Obstetric hemorrhage.","volume":"9","author":"McLintock","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"5","key":"zoi190593r13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.","volume":"313","author":"Holcomb","year":"2015","journal-title":"JAMA"},{"issue":"3","key":"zoi190593r14","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ajog.2015.08.068","article-title":"An update on the use of massive transfusion protocols in obstetrics.","volume":"214","author":"Pacheco","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"zoi190593r15","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1213\/ANE.0b013e31826f084d","article-title":"An observational study of the fresh frozen plasma: red blood cell ratio in postpartum hemorrhage.","volume":"116","author":"Pasquier","year":"2013","journal-title":"Anesth Analg"},{"issue":"1","key":"zoi190593r16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ijoa.2011.09.009","article-title":"Transfusion practice in major obstetric haemorrhage: lessons from trauma.","volume":"21","author":"Saule","year":"2012","journal-title":"Int J Obstet Anesth"},{"issue":"4","key":"zoi190593r17","doi-asserted-by":"publisher","first-page":"368.e1","DOI":"10.1016\/j.ajog.2011.06.084","article-title":"Comprehensive maternal hemorrhage protocols improve patient safety and reduce utilization of blood products.","volume":"205","author":"Shields","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"zoi190593r18","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ajog.2014.07.012","article-title":"Comprehensive maternal hemorrhage protocols reduce the use of blood products and improve patient safety.","volume":"212","author":"Shields","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"zoi190593r19","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1111\/trf.2007.47.issue-9","article-title":"How we treat: management of life-threatening primary postpartum hemorrhage with a standardized massive transfusion protocol.","volume":"47","author":"Burtelow","year":"2007","journal-title":"Transfusion"},{"issue":"3","key":"zoi190593r20","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/bja\/aex245","article-title":"Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study.","volume":"119","author":"Collins","year":"2017","journal-title":"Br J Anaesth"},{"key":"zoi190593r22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejogrb.2015.12.012","article-title":"Postpartum hemorrhage: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF): in collaboration with the French Society of Anesthesiology and Intensive Care (SFAR).","volume":"198","author":"Sentilhes","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"zoi190593r23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ejogrb.2019.01.027","article-title":"Fluid resuscitation during persistent postpartum haemorrhage and maternal outcome: a nationwide cohort study.","volume":"235","author":"Henriquez","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"9734","key":"zoi190593r24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.","volume":"376","author":"Shakur","year":"2010","journal-title":"Lancet"},{"issue":"10084","key":"zoi190593r25","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.","volume":"389","author":"WOMAN Trial Collaborators","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"zoi190593r26","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1001\/jama.2016.20165","article-title":"Association between tracheal intubation during adult in-hospital cardiac arrest and survival.","volume":"317","author":"Andersen","year":"2017","journal-title":"JAMA"},{"issue":"17","key":"zoi190593r27","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1001\/jama.2016.14486","article-title":"Association between tracheal intubation during pediatric in-hospital cardiac arrest and survival.","volume":"316","author":"Andersen","year":"2016","journal-title":"JAMA"},{"issue":"3","key":"zoi190593r28","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies.","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav Res"},{"issue":"3","key":"zoi190593r29","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/j.1541-0420.2005.00356.x","article-title":"Propensity score matching with time-dependent covariates.","volume":"61","author":"Lu","year":"2005","journal-title":"Biometrics"},{"key":"zoi190593r30","doi-asserted-by":"publisher","first-page":"f6829","DOI":"10.1136\/bmj.f6829","article-title":"Evaluation of pre-hospital administration of adrenaline (epinephrine) by emergency medical services for patients with out of hospital cardiac arrest in Japan: controlled propensity matched retrospective cohort study.","volume":"347","author":"Nakahara","year":"2013","journal-title":"BMJ"},{"issue":"6","key":"zoi190593r31","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-015735","article-title":"Risk of death among users of proton pump inhibitors: a longitudinal observational cohort study of United States veterans.","volume":"7","author":"Xie","year":"2017","journal-title":"BMJ Open"},{"issue":"5","key":"zoi190593r32","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1097\/ALN.0b013e3181f22b5a","article-title":"Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution.","volume":"113","author":"Bolliger","year":"2010","journal-title":"Anesthesiology"},{"key":"zoi190593r33","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12884-015-0653-6","article-title":"Is accurate and reliable blood loss estimation the \u2018crucial step\u2019 in early detection of postpartum haemorrhage: an integrative review of the literature.","volume":"15","author":"Hancock","year":"2015","journal-title":"BMC Pregnancy Childbirth"},{"issue":"2","key":"zoi190593r34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00404-014-3352-z","article-title":"The impact of maternal obesity, age, pre-eclampsia and insulin dependent diabetes on severe maternal morbidity by mode of delivery: a register-based cohort study.","volume":"291","author":"Pallasmaa","year":"2015","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"zoi190593r35","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1160\/TH09-06-0396","article-title":"Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery.","volume":"103","author":"Schols","year":"2010","journal-title":"Thromb Haemost"},{"key":"zoi190593r36","article-title":"Management of postpartum hemorrhage: how to improve maternal outcomes [published online June 8, 2018].","author":"Henriquez","journal-title":"J Thromb Haemost"},{"issue":"2","key":"zoi190593r37","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/pst.v10.2","article-title":"Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.","volume":"10","author":"Austin","year":"2011","journal-title":"Pharm Stat"},{"issue":"6","key":"zoi190593r38","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/sim.6004","article-title":"A comparison of 12 algorithms for matching on the propensity score.","volume":"33","author":"Austin","year":"2014","journal-title":"Stat Med"},{"issue":"2","key":"zoi190593r39","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/aje\/kwt212","article-title":"Selecting an appropriate caliper can be essential for achieving good balance with propensity score matching.","volume":"179","author":"Lunt","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"24","key":"zoi190593r40","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1001\/jama.2015.6734","article-title":"Association between early screening for patent ductus arteriosus and in-hospital mortality among extremely preterm infants.","volume":"313","author":"Roz\u00e9","year":"2015","journal-title":"JAMA"},{"issue":"7","key":"zoi190593r41","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.jclinepi.2009.12.008","article-title":"Missing covariate data in medical research: to impute is better than to ignore.","volume":"63","author":"Janssen","year":"2010","journal-title":"J Clin Epidemiol"},{"issue":"10","key":"zoi190593r42","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.jclinepi.2006.01.009","article-title":"Using the outcome for imputation of missing predictor values was preferred.","volume":"59","author":"Moons","year":"2006","journal-title":"J Clin Epidemiol"},{"issue":"18","key":"zoi190593r43","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1001\/jama.2015.15281","article-title":"Multiple imputation: a flexible tool for handling missing data.","volume":"314","author":"Li","year":"2015","journal-title":"JAMA"},{"issue":"1","key":"zoi190593r44","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1177\/0962280212445945","article-title":"A comparison of two methods of estimating propensity scores after multiple imputation.","volume":"25","author":"Mitra","year":"2016","journal-title":"Stat Methods Med Res"},{"issue":"6","key":"zoi190593r45","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1177\/0962280216674296","article-title":"Comments on propensity score matching following multiple imputation.","volume":"25","author":"Penning de Vries","year":"2016","journal-title":"Stat Methods Med Res"},{"issue":"4","key":"zoi190593r46","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Multiple imputation in health-care databases: an overview and some applications.","volume":"10","author":"Rubin","year":"1991","journal-title":"Stat Med"},{"issue":"25","key":"zoi190593r47","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1002\/sim.3697","article-title":"Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.","volume":"28","author":"Austin","year":"2009","journal-title":"Stat Med"},{"issue":"11","key":"zoi190593r48","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1002\/pds.v20.11","article-title":"Measuring balance and model selection in propensity score methods.","volume":"20","author":"Belitser","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"2","key":"zoi190593r49","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jclinepi.2014.08.011","article-title":"Reporting of covariate selection and balance assessment in propensity score analysis is suboptimal: a systematic review.","volume":"68","author":"Ali","year":"2015","journal-title":"J Clin Epidemiol"},{"issue":"11","key":"zoi190593r50","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1002\/pds.v20.11","article-title":"Balance measures for propensity score methods: a clinical example on beta-agonist use and the risk of myocardial infarction.","volume":"20","author":"Groenwold","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"zoi190593r51","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0895-4356(00)00321-8","article-title":"Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores.","volume":"54","author":"Normand","year":"2001","journal-title":"J Clin Epidemiol"},{"issue":"15","key":"zoi190593r52","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1001\/jama.2015.13480","article-title":"The propensity score.","volume":"314","author":"Haukoos","year":"2015","journal-title":"JAMA"},{"issue":"3","key":"zoi190593r53","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/bja\/aex181","article-title":"Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial.","volume":"119","author":"Collins","year":"2017","journal-title":"Br J Anaesth"},{"issue":"4","key":"zoi190593r54","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/bja\/aeu444","article-title":"Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial.","volume":"114","author":"Wikkels\u00f8","year":"2015","journal-title":"Br J Anaesth"},{"issue":"19","key":"zoi190593r55","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1182\/bloodadvances.2018022632","article-title":"Coagulation parameters during the course of severe postpartum hemorrhage: a nationwide retrospective cohort study.","volume":"2","author":"Gillissen","year":"2018","journal-title":"Blood Adv"},{"key":"zoi190593r21","unstructured":"Netherlands Trial Register. Transfusion strategies in women during major obstetric haemorrhage. https:\/\/www.trialregister.nl\/trial\/3909. Accessed July 19, 2019."}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2755490\/henriquez_2019_oi_190593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:43:48Z","timestamp":1573818228000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2755490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":55,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.15628","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]}}}