{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:38:05Z","timestamp":1790534285152,"version":"4.1.0"},"reference-count":26,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.18070","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T16:31:04Z","timestamp":1576686664000},"page":"e1918070","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Concurrent Chemoradiation With Celecoxib vs Concurrent Chemoradiation Alone on Survival Among Patients With Non\u2013Small Cell Lung Cancer With and Without Cyclooxygenase 2 Genetic Variants"],"prefix":"10.1001","volume":"2","author":[{"given":"Nan","family":"Bi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongmei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixue","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QinFu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouguang","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefen","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jima","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center and Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Department of Radiation Oncology, Shenzhen Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"issue":"1","key":"zoi190682r1","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1378\/chest.128.1.452","article-title":"Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003.","volume":"128","author":"Yang","year":"2005","journal-title":"Chest"},{"issue":"13","key":"zoi190682r2","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1200\/JCO.2009.26.2543","article-title":"Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer.","volume":"28","author":"Aup\u00e9rin","year":"2010","journal-title":"J Clin Oncol"},{"issue":"2","key":"zoi190682r3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.semradonc.2014.11.003","article-title":"Superiority of concomitant chemoradiation over sequential chemoradiation in inoperable, locally advanced non-small cell lung cancer: challenges in the selection of appropriate chemotherapy.","volume":"25","author":"Bi","year":"2015","journal-title":"Semin Radiat Oncol"},{"issue":"17","key":"zoi190682r4","first-page":"3761","article-title":"Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.","volume":"58","author":"Hida","year":"1998","journal-title":"Cancer Res"},{"issue":"22","key":"zoi190682r5","first-page":"4997","article-title":"Expression of cyclooxygenase-2 in human lung carcinoma.","volume":"58","author":"Wolff","year":"1998","journal-title":"Cancer Res"},{"issue":"5","key":"zoi190682r6","first-page":"1001","article-title":"Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas.","volume":"5","author":"Achiwa","year":"1999","journal-title":"Clin Cancer Res"},{"issue":"8","key":"zoi190682r7","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1158\/1078-0432.CCR-09-2793","article-title":"Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer.","volume":"16","author":"Bi","year":"2010","journal-title":"Clin Cancer Res"},{"issue":"3","key":"zoi190682r8","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/00000658-200203000-00017","article-title":"Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer.","volume":"235","author":"Brabender","year":"2002","journal-title":"Ann Surg"},{"issue":"4","key":"zoi190682r9","first-page":"861","article-title":"Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer.","volume":"7","author":"Khuri","year":"2001","journal-title":"Clin Cancer Res"},{"issue":"6","key":"zoi190682r10","first-page":"2513","article-title":"Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor.","volume":"6","author":"Petersen","year":"2000","journal-title":"Clin Cancer Res"},{"issue":"1","key":"zoi190682r11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3349\/ymj.2006.47.1.15","article-title":"Genetic markers for differentiating aspirin-hypersensitivity.","volume":"47","author":"Kim","year":"2006","journal-title":"Yonsei Med J"},{"issue":"10","key":"zoi190682r12","first-page":"2998","article-title":"A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2.","volume":"7","author":"Pyo","year":"2001","journal-title":"Clin Cancer Res"},{"issue":"9","key":"zoi190682r13","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1158\/1078-0432.CCR-04-1741","article-title":"A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable\/unresectable non-small cell lung cancer.","volume":"11","author":"Liao","year":"2005","journal-title":"Clin Cancer Res"},{"key":"zoi190682r14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fonc.2011.00052","article-title":"Phase I study of celecoxib with concurrent irinotecan, cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer.","volume":"1","author":"Komaki","year":"2011","journal-title":"Front Oncol"},{"issue":"2","key":"zoi190682r15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cllc.2011.03.007","article-title":"Phase I\/II trial of a COX-2 inhibitor with limited field radiation for intermediate prognosis patients who have locally advanced non-small-cell lung cancer: Radiation Therapy Oncology Group 0213.","volume":"12","author":"Gore","year":"2011","journal-title":"Clin Lung Cancer"},{"issue":"2","key":"zoi190682r16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ijrobp.2012.04.025","article-title":"Mitigation and treatment of radiation-induced thoracic injury with a cyclooxygenase-2 inhibitor, celecoxib.","volume":"85","author":"Hunter","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"19","key":"zoi190682r17","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1093\/jnci\/djr325","article-title":"Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410.","volume":"103","author":"Curran","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"zoi190682r18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/annonc\/mdx009","article-title":"Etoposide and cisplatin versus paclitaxel and carboplatin with concurrent thoracic radiotherapy in unresectable stage III non-small cell lung cancer: a multicenter randomized phase III trial.","volume":"28","author":"Liang","year":"2017","journal-title":"Ann Oncol"},{"issue":"2","key":"zoi190682r19","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.ijrobp.2012.04.043","article-title":"Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis.","volume":"85","author":"Palma","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"32","key":"zoi190682r20","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1200\/JCO.2011.35.5214","article-title":"Randomized, placebo-controlled phase III study of docetaxel plus carboplatin with celecoxib and cyclooxygenase-2 expression as a biomarker for patients with advanced non-small-cell lung cancer: the NVALT-4 Study.","volume":"29","author":"Groen","year":"2011","journal-title":"J Clin Oncol"},{"issue":"19","key":"zoi190682r21","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1200\/JCO.2016.71.3743","article-title":"Phase III randomized, placebo-controlled, double-blind trial of celecoxib in addition to standard chemotherapy for advanced non-small-cell lung cancer with cyclooxygenase-2 overexpression: CALGB 30801 (Alliance).","volume":"35","author":"Edelman","year":"2017","journal-title":"J Clin Oncol"},{"issue":"11","key":"zoi190682r22","doi-asserted-by":"publisher","first-page":"4191","DOI":"10.1158\/1078-0432.CCR-05-0108","article-title":"Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer.","volume":"11","author":"Altorki","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"2","key":"zoi190682r23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1200\/JCO.2014.55.5789","article-title":"Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer.","volume":"33","author":"Edelman","year":"2015","journal-title":"J Clin Oncol"},{"issue":"2","key":"zoi190682r24","first-page":"565","article-title":"Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.","volume":"129","author":"Zhang","year":"2005","journal-title":"Gastroenterology"},{"issue":"1-2","key":"zoi190682r25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.mrfmmm.2007.11.004","article-title":"Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study.","volume":"639","author":"Vogel","year":"2008","journal-title":"Mutat Res"},{"issue":"4","key":"zoi190682r26","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1159\/000108407","article-title":"MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer.","volume":"75","author":"Pan","year":"2008","journal-title":"Respiration"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2757632\/bi_2019_oi_190682.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T03:03:16Z","timestamp":1613185396000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2757632"}},"subtitle":["A Phase 2 Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.18070","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]}}}