{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:10:48Z","timestamp":1791486648165,"version":"4.3.4"},"reference-count":46,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.4428","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T15:39:21Z","timestamp":1558712361000},"page":"e194428","source":"Crossref","is-referenced-by-count":108,"title":["Evaluation of Cancer-Based Criteria for Use in Mainstream<i>BRCA1<\/i>and<i>BRCA2<\/i>Genetic Testing in Patients With Breast Cancer"],"prefix":"10.1001","volume":"2","author":[{"given":"Zoe","family":"Kemp","sequence":"first","affiliation":[{"name":"Breast Unit, Royal Marsden National Health Service Foundation Trust, London, United Kingdom"},{"name":"Cancer Genetics Unit, Royal Marsden National Health Service Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Yost","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"},{"name":"TGLclinical, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Seal","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"},{"name":"TGLclinical, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Mahamdallie","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"},{"name":"TGLclinical, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Poyastro-Pearson","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"},{"name":"TGLclinical, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Warren-Perry","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Eccleston","sequence":"additional","affiliation":[{"name":"DRG Abacus, Bicester, Oxfordshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Min","family":"Tan","sequence":"additional","affiliation":[{"name":"Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hwang","family":"Teo","sequence":"additional","affiliation":[{"name":"Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia"},{"name":"Department of Surgery, Faculty of Medicine, University Malaya, Kuala Lumpar, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Turner","sequence":"additional","affiliation":[{"name":"Breast Unit, Royal Marsden National Health Service Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Strydom","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"},{"name":"TGLclinical, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"George","sequence":"additional","affiliation":[{"name":"Cancer Genetics Unit, Royal Marsden National Health Service Foundation Trust, London, United Kingdom"},{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"},{"name":"TGLclinical, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazneen","family":"Rahman","sequence":"additional","affiliation":[{"name":"Cancer Genetics Unit, Royal Marsden National Health Service Foundation Trust, London, United Kingdom"},{"name":"Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom"},{"name":"TGLclinical, Institute of Cancer Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"zoi190194r1","doi-asserted-by":"publisher","first-page":"vi31","DOI":"10.1093\/annonc\/mdr373","article-title":"BRCA in breast cancer: ESMO clinical practice guidelines.","volume":"22","author":"Balma\u00f1a","year":"2011","journal-title":"Ann Oncol"},{"issue":"1","key":"zoi190194r2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ijc.v141.1","article-title":"The spectrum of BRCA mutations and characteristics of BRCA-associated breast cancers in China: screening of 2,991 patients and 1,043 controls by next-generation sequencing.","volume":"141","author":"Lang","year":"2017","journal-title":"Int J Cancer"},{"issue":"5","key":"zoi190194r3","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1002\/ijc.v144.5","article-title":"Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort.","volume":"144","author":"Li","year":"2019","journal-title":"Int J Cancer"},{"key":"zoi190194r4","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.breast.2016.11.021","article-title":"BRCA mutation genetic testing implications in the United States.","volume":"31","author":"Bayraktar","year":"2017","journal-title":"Breast"},{"issue":"2","key":"zoi190194r5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41416-018-0127-5","article-title":"BRCA 1\/2 testing: therapeutic implications for breast cancer management.","volume":"119","author":"Tung","year":"2018","journal-title":"Br J Cancer"},{"issue":"27","key":"zoi190194r6","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.1200\/JCO.2010.28.0719","article-title":"Expanding the criteria for BRCA mutation testing in breast cancer survivors.","volume":"28","author":"Kwon","year":"2010","journal-title":"J Clin Oncol"},{"issue":"4","key":"zoi190194r7","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.jval.2017.01.004","article-title":"A cost-effectiveness evaluation of germline BRCA1 and BRCA2 testing in UK women with ovarian cancer.","volume":"20","author":"Eccleston","year":"2017","journal-title":"Value Health"},{"issue":"9","key":"zoi190194r8","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/gim.2017.231","article-title":"Cost-effectiveness analysis of germ-line BRCA testing in women with breast cancer and cascade testing in family members of mutation carriers.","volume":"20","author":"Tuffaha","year":"2018","journal-title":"Genet Med"},{"issue":"10","key":"zoi190194r9","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/gim.2017.255","article-title":"Cost-effectiveness and comparative effectiveness of cancer risk management strategies in BRCA1\/2 mutation carriers: a systematic review.","volume":"20","author":"Petelin","year":"2018","journal-title":"Genet Med"},{"issue":"3","key":"zoi190194r10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s40258-018-0384-8","article-title":"Is BRCA mutation testing cost effective for early stage breast cancer patients compared to routine clinical surveillance? the case of an upper middle-income country in Asia.","volume":"16","author":"Lim","year":"2018","journal-title":"Appl Health Econ Health Policy"},{"issue":"3","key":"zoi190194r11","doi-asserted-by":"publisher","first-page":"e000328","DOI":"10.1136\/esmoopen-2018-000328","article-title":"BRCA mutation carrier detection: a model-based cost-effectiveness analysis comparing the traditional family history approach and the testing of all patients with breast cancer.","volume":"3","author":"Norum","year":"2018","journal-title":"ESMO Open"},{"issue":"1","key":"zoi190194r12","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12885-018-4029-y","article-title":"Prevalence of pathogenic BRCA1\/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history.","volume":"18","author":"Engel","year":"2018","journal-title":"BMC Cancer"},{"issue":"5","key":"zoi190194r14","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/ejhg.2014.161","article-title":"Evaluation of the Dutch BRCA 1\/2 clinical genetic center referral criteria in an unselected early breast cancer population.","volume":"23","author":"van den Broek","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"4","key":"zoi190194r15","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1158\/1055-9965.EPI-12-1280","article-title":"Prevalence and healthcare actions of women in a large health system with a family history meeting the 2005 USPSTF recommendation for BRCA genetic counseling referral.","volume":"22","author":"Bellcross","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"zoi190194r16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/gim.2014.68","article-title":"Characteristics associated with genetic counseling referral and BRCA1\/2 testing among women in a large integrated health system.","volume":"17","author":"Bellcross","year":"2015","journal-title":"Genet Med"},{"key":"zoi190194r17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1471-2296-11-45","article-title":"Primary care physicians\u2019 use of family history for cancer risk assessment.","volume":"11","author":"Flynn","year":"2010","journal-title":"BMC Fam Pract"},{"issue":"3","key":"zoi190194r18","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/imj.2017.47.issue-3","article-title":"Breast and ovarian cancer referrals to the ACT Genetic Service: are we meeting guidelines?","volume":"47","author":"Aitken","year":"2017","journal-title":"Intern Med J"},{"issue":"1","key":"zoi190194r19","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s10689-016-9921-5","article-title":"BRCA testing within the Department of Veterans Affairs: concordance with clinical practice guidelines.","volume":"16","author":"Chun","year":"2017","journal-title":"Fam Cancer"},{"issue":"6","key":"zoi190194r20","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.amepre.2017.01.027","article-title":"Use of BRCA mutation Test in the US, 2004-2014.","volume":"52","author":"Guo","year":"2017","journal-title":"Am J Prev Med"},{"issue":"3","key":"zoi190194r21","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s10549-018-5035-0","article-title":"Concordance with BRCA1\/2 testing guidelines among women in The Health of Women (HOW) Study.","volume":"173","author":"Silver","year":"2019","journal-title":"Breast Cancer Res Treat"},{"issue":"23","key":"zoi190194r22","doi-asserted-by":"publisher","first-page":"5334","DOI":"10.1002\/cncr.v117.23","article-title":"Reported referral for genetic counseling or BRCA 1\/2 testing among United States physicians: a vignette-based study.","volume":"117","author":"Trivers","year":"2011","journal-title":"Cancer"},{"issue":"11","key":"zoi190194r23","doi-asserted-by":"publisher","first-page":"e0187630","DOI":"10.1371\/journal.pone.0187630","article-title":"BRCA1 and BRCA2 mutational profile and prevalence in hereditary breast and ovarian cancer (HBOC) probands from Southern Brazil: are international testing criteria appropriate for this specific population?","volume":"12","author":"Alemar","year":"2017","journal-title":"PLoS One"},{"issue":"11","key":"zoi190194r24","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.ejca.2007.04.023","article-title":"Genetic epidemiology of BRCA mutations\u2014family history detects less than 50% of the mutation carriers.","volume":"43","author":"M\u00f8ller","year":"2007","journal-title":"Eur J Cancer"},{"issue":"5","key":"zoi190194r25","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1001\/jama.2016.16918","article-title":"Genetic testing and counseling among patients with newly diagnosed breast cancer.","volume":"317","author":"Kurian","year":"2017","journal-title":"JAMA"},{"issue":"1","key":"zoi190194r26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10549-013-2669-9","article-title":"Lack of referral for genetic counseling and testing in BRCA1\/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests.","volume":"141","author":"Pujol","year":"2013","journal-title":"Breast Cancer Res Treat"},{"issue":"34","key":"zoi190194r27","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1200\/JCO.2017.73.6314","article-title":"National estimates of genetic testing in women with a history of breast or ovarian cancer.","volume":"35","author":"Childers","year":"2017","journal-title":"J Clin Oncol"},{"issue":"6","key":"zoi190194r28","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1245\/s10434-012-2257-y","article-title":"Hereditary breast and ovarian cancer and other hereditary syndromes: using technology to identify carriers.","volume":"19","author":"Drohan","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"zoi190194r29","doi-asserted-by":"publisher","first-page":"29506","DOI":"10.1038\/srep29506","article-title":"Implementing rapid, robust, cost-effective, patient-centered, routine genetic testing in ovarian cancer patients.","volume":"6","author":"George","year":"2016","journal-title":"Sci Rep"},{"issue":"6","key":"zoi190194r30","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/ejhg.2015.196","article-title":"BRCA1\/2 testing in newly diagnosed breast and ovarian cancer patients without prior genetic counselling: the DNA-BONus study.","volume":"24","author":"H\u00f8berg-Vetti","year":"2016","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"zoi190194r31","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ygyno.2017.01.030","article-title":"Mainstreaming cancer genetics: a model integrating germline BRCA testing into routine ovarian cancer clinics.","volume":"145","author":"Kentwell","year":"2017","journal-title":"Gynecol Oncol"},{"issue":"2","key":"zoi190194r32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10549-018-5000-y","article-title":"High patient satisfaction with a simplified BRCA1\/2 testing procedure: long-term results of a prospective study.","volume":"173","author":"Nilsson","year":"2019","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"zoi190194r33","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10549-017-4584-y","article-title":"BRCAsearch: written pre-test information and BRCA1\/2 germline mutation testing in unselected patients with newly diagnosed breast cancer.","volume":"168","author":"Nilsson","year":"2018","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"zoi190194r34","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1136\/jmedgenet-2017-105140","article-title":"Mainstreamed genetic testing for women with ovarian cancer: first-year experience.","volume":"56","author":"Rahman","year":"2019","journal-title":"J Med Genet"},{"issue":"2","key":"zoi190194r35","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1136\/jmedgenet-2017-104947","article-title":"Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia.","volume":"55","author":"Wen","year":"2018","journal-title":"J Med Genet"},{"issue":"7","key":"zoi190194r36","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1136\/jmg.2005.031989","article-title":"Update on the Manchester Scoring System for BRCA1 and BRCA2 testing.","volume":"42","author":"Evans","year":"2005","journal-title":"J Med Genet"},{"issue":"2","key":"zoi190194r37","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/bjc.2013.730","article-title":"BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface.","volume":"110","author":"Lee","year":"2014","journal-title":"Br J Cancer"},{"issue":"1","key":"zoi190194r38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.6004\/jnccn.2017.0003","article-title":"NCCN guidelines insights: genetic\/familial high-risk assessment: breast and ovarian, version 2.2017.","volume":"15","author":"Daly","year":"2017","journal-title":"J Natl Compr Canc Netw"},{"issue":"6","key":"zoi190194r39","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/jmedgenet-2017-105188","article-title":"Consensus for genes to be included on cancer panel tests offered by UK genetics services: guidelines of the UK Cancer Genetics Group.","volume":"55","author":"Taylor","year":"2018","journal-title":"J Med Genet"},{"issue":"6","key":"zoi190194r40","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/ejhg.2014.180","article-title":"A systematic review of factors that act as barriers to patient referral to genetic services.","volume":"23","author":"Delikurt","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"20","key":"zoi190194r41","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1200\/JCO.2016.71.6480","article-title":"Gaps in incorporating germline genetic testing into treatment decision-making for early-stage breast cancer.","volume":"35","author":"Kurian","year":"2017","journal-title":"J Clin Oncol"},{"issue":"4","key":"zoi190194r42","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1200\/JCO.2014.57.1414","article-title":"Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.","volume":"33","author":"Couch","year":"2015","journal-title":"J Clin Oncol"},{"issue":"11","key":"zoi190194r43","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1007\/s00432-015-1986-2","article-title":"Evaluation of BRCA1\/2 mutational status among German and Austrian women with triple-negative breast cancer.","volume":"141","author":"Muendlein","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"zoi190194r44","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s10549-016-4003-9","article-title":"Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care.","volume":"160","author":"Graffeo","year":"2016","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"zoi190194r45","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s10689-016-9953-x","article-title":"Efficacy versus effectiveness of clinical genetic testing criteria for BRCA1 and BRCA2 hereditary mutations in incident breast cancer.","volume":"16","author":"Nilsson","year":"2017","journal-title":"Fam Cancer"},{"key":"zoi190194r13","volume-title":"Classification and Care of People at Risk of Familial Breast Cancer and Management of Breast Cancer and Related Risks in People With a Family History of Breast Cancer","author":"National Collaborating Centre for Cancer","year":"2013"},{"key":"zoi190194r46","unstructured":"Mainstreaming Cancer Genetics. http:\/\/www.mcgprogramme.com. Accessed December 1, 2018."}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jamanetworkopen\/article-pdf\/2\/5\/e194428\/17590263\/kemp_2019_oi_190194.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T09:56:41Z","timestamp":1574762201000},"score":1,"resource":{"primary":{"URL":"http:\/\/jamanetworkopen.jamanetwork.com\/article.aspx?doi=10.1001\/jamanetworkopen.2019.4428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5,3]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.4428","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,24]]}}}