{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:52:26Z","timestamp":1789685546645,"version":"4.0.1"},"reference-count":39,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.5536","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T11:04:50Z","timestamp":1559905490000},"page":"e195536","source":"Crossref","is-referenced-by-count":82,"title":["Incidence, Risk Factors, and Mortality Associated With Second Malignant Neoplasms Among Survivors of Adolescent and Young Adult Cancer"],"prefix":"10.1001","volume":"2","author":[{"given":"Chun","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship, School of Medicine, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfang","family":"Xu","sequence":"additional","affiliation":[{"name":"MedHealth Statistical Consulting Inc, Solon, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly L.","family":"Cannavale","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Lennie","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Population Sciences, City of Hope, Duarte, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Yin Samuel","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Los Angeles Medical Center, Kaiser Permanente Southern California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Los Angeles Medical Center, Kaiser Permanente Southern California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saro H.","family":"Armenian","sequence":"additional","affiliation":[{"name":"Department of Population Sciences, City of Hope, Duarte, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"issue":"5","key":"zoi190226r1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/jnci\/djr533","article-title":"Second malignant neoplasms and cardiovascular disease following radiotherapy.","volume":"104","author":"Travis","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"30","key":"zoi190226r2","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1200\/JCO.2012.41.8681","article-title":"Second malignant neoplasms: assessment and strategies for risk reduction.","volume":"30","author":"Wood","year":"2012","journal-title":"J Clin Oncol"},{"issue":"14","key":"zoi190226r3","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1200\/JCO.2008.21.1425","article-title":"Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study.","volume":"27","author":"Armstrong","year":"2009","journal-title":"J Clin Oncol"},{"issue":"19","key":"zoi190226r4","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1002\/cncr.v122.19","article-title":"Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008.","volume":"122","author":"Donin","year":"2016","journal-title":"Cancer"},{"issue":"9","key":"zoi190226r5","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1093\/annonc\/mdp037","article-title":"Early detection of second breast cancers improves prognosis in breast cancer survivors.","volume":"20","author":"Houssami","year":"2009","journal-title":"Ann Oncol"},{"issue":"4","key":"zoi190226r6","doi-asserted-by":"publisher","first-page":"277","DOI":"10.14366\/usg.18017","article-title":"Screening women with a personal history of breast cancer: overview of the evidence on breast imaging surveillance.","volume":"37","author":"Houssami","year":"2018","journal-title":"Ultrasonography"},{"issue":"22","key":"zoi190226r7","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1200\/JCO.2011.34.6585","article-title":"Occurrence of multiple subsequent neoplasms in long-term survivors of childhood cancer: a report from the childhood cancer survivor study.","volume":"29","author":"Armstrong","year":"2011","journal-title":"J Clin Oncol"},{"issue":"14","key":"zoi190226r8","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1093\/jnci\/djq238","article-title":"Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study.","volume":"102","author":"Friedman","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"zoi190226r9","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1200\/JCO.2005.02.7235","article-title":"Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.","volume":"24","author":"Bassal","year":"2006","journal-title":"J Clin Oncol"},{"issue":"8","key":"zoi190226r10","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1002\/ijc.28991","article-title":"Secondary malignancies in pediatric cancer survivors: perspectives and review of the literature.","volume":"135","author":"Choi","year":"2014","journal-title":"Int J Cancer"},{"issue":"8","key":"zoi190226r11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1001\/jama.2017.0693","article-title":"Temporal trends in treatment and subsequent neoplasm risk among 5-year survivors of childhood cancer, 1970-2015.","volume":"317","author":"Turcotte","year":"2017","journal-title":"JAMA"},{"issue":"12","key":"zoi190226r12","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1093\/annonc\/mdr044","article-title":"Late effects in survivors of teenage and young adult cancer: does age matter?","volume":"22","author":"Woodward","year":"2011","journal-title":"Ann Oncol"},{"key":"zoi190226r13","doi-asserted-by":"crossref","first-page":"103032","DOI":"10.1155\/2012\/103032","article-title":"Risk of late mortality and second malignant neoplasms among 5-year survivors of young adult cancer: a report of the Childhood, Adolescent, and Young Adult Cancer Survivors Research Program.","volume":"2012","author":"Zhang","year":"2012","journal-title":"J Cancer Epidemiol"},{"issue":"1","key":"zoi190226r14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/cncr.29685","article-title":"Increased risk of second malignant neoplasms in adolescents and young adults with cancer.","volume":"122","author":"Lee","year":"2016","journal-title":"Cancer"},{"issue":"7","key":"zoi190226r15","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3109\/0284186X.2012.705891","article-title":"Cancer in adolescents and young adults (15-29 years): a population-based study in the Netherlands 1989-2009.","volume":"51","author":"Aben","year":"2012","journal-title":"Acta Oncol"},{"issue":"19","key":"zoi190226r16","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1093\/jnci\/89.19.1429","article-title":"Risk of second malignant neoplasms among long-term survivors of testicular cancer.","volume":"89","author":"Travis","year":"1997","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"zoi190226r17","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1200\/JCO.2000.18.3.498","article-title":"Risk of second malignancy after Hodgkin\u2019s disease in a collaborative British cohort: the relation to age at treatment.","volume":"18","author":"Swerdlow","year":"2000","journal-title":"J Clin Oncol"},{"issue":"5","key":"zoi190226r18","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/sj.bjc.6604241","article-title":"Second malignancies after breast cancer: the impact of different treatment modalities.","volume":"98","author":"Kirova","year":"2008","journal-title":"Br J Cancer"},{"issue":"2","key":"zoi190226r19","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/cncr.29025","article-title":"Elevated risks of subsequent primary malignancies in patients with thyroid cancer: a nationwide, population-based study in Korea.","volume":"121","author":"Cho","year":"2015","journal-title":"Cancer"},{"issue":"1","key":"zoi190226r20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jdermsci.2014.02.007","article-title":"The risk of developing a second primary cancer in melanoma patients: a comprehensive review of the literature and meta-analysis.","volume":"75","author":"Caini","year":"2014","journal-title":"J Dermatol Sci"},{"issue":"8987","key":"zoi190226r21","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/S0140-6736(95)92449-3","article-title":"Pros and cons of standardised mortality ratios.","volume":"346","author":"Court","year":"1995","journal-title":"Lancet"},{"issue":"36","key":"zoi190226r22","doi-asserted-by":"publisher","first-page":"9187","DOI":"10.1200\/JCO.2005.01.7418","article-title":"Health insurance coverage in survivors of childhood cancer: the Childhood Cancer Survivor Study.","volume":"23","author":"Park","year":"2005","journal-title":"J Clin Oncol"},{"issue":"3","key":"zoi190226r23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.7812\/TPP\/12-031","article-title":"Sociodemographic characteristics of members of a large, integrated health care system: comparison with US Census Bureau data.","volume":"16","author":"Koebnick","year":"2012","journal-title":"Perm J"},{"issue":"2","key":"zoi190226r24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/jayao.2012.0024","article-title":"Exploring the feasibility of establishing a retrospective cohort of survivors of adolescent and young adult cancer to study long-term health outcomes in an integrated managed care environment.","volume":"2","author":"Chao","year":"2013","journal-title":"J Adolesc Young Adult Oncol"},{"issue":"6","key":"zoi190226r26","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/EDE.0b013e3181577654","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"18","author":"von Elm","year":"2007","journal-title":"Epidemiology"},{"key":"zoi190226r30","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A class of K-sample tests for comparing the cumulative incidence of a competing risk.","volume":"16","author":"Gary","year":"1988","journal-title":"Ann Stat"},{"issue":"8","key":"zoi190226r32","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1002\/ijc.28988","article-title":"Multiple primary cancers as a guide to heritability.","volume":"135","author":"Cybulski","year":"2014","journal-title":"Int J Cancer"},{"issue":"2","key":"zoi190226r33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/aps.2015.89","article-title":"Cancer predisposition genes: molecular mechanisms and clinical impact on personalized cancer care: examples of Lynch and HBOC syndromes.","volume":"37","author":"Wang","year":"2016","journal-title":"Acta Pharmacol Sin"},{"issue":"11","key":"zoi190226r35","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1001\/jamaoncol.2017.0465","article-title":"Second primary malignant neoplasms and survival in adolescent and young adult cancer survivors.","volume":"3","author":"Keegan","year":"2017","journal-title":"JAMA Oncol"},{"issue":"31","key":"zoi190226r36","doi-asserted-by":"publisher","first-page":"3544","DOI":"10.1200\/JCO.2015.61.4503","article-title":"High prevalence of hereditary cancer syndromes in adolescents and young adults with colorectal cancer.","volume":"33","author":"Mork","year":"2015","journal-title":"J Clin Oncol"},{"issue":"3","key":"zoi190226r37","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/MPH.0b013e3181ced34c","article-title":"Inherited cancer syndromes in children and young adults.","volume":"32","author":"D\u2019Orazio","year":"2010","journal-title":"J Pediatr Hematol Oncol"},{"issue":"4","key":"zoi190226r38","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S1470-2045(11)70061-4","article-title":"Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries.","volume":"12","author":"Berrington de Gonzalez","year":"2011","journal-title":"Lancet Oncol"},{"issue":"3","key":"zoi190226r39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11764-011-0173-y","article-title":"Recruitment and follow-up of adolescent and young adult cancer survivors: the AYA HOPE Study.","volume":"5","author":"Harlan","year":"2011","journal-title":"J Cancer Surviv"},{"key":"zoi190226r27","volume-title":"The 2007 Multiple Primary and Histology Coding Rules","author":"Johnson","year":"2007"},{"key":"zoi190226r31","volume-title":"New Malignancies Among Cancer Survivors: SEER Cancer Registries, 1973-2000","author":"Curtis","year":"2006"},{"key":"zoi190226r34","volume-title":"SEER Cancer Statistics Review, 1975-2014","author":"Howlader","year":"2017"},{"key":"zoi190226r25","unstructured":"California Cancer Registry. About data from the CCR. Accessed December 2015. http:\/\/www.ccrcal.org\/Data_and_Statistics\/About_Data_from_the_CCR.shtml, California Department of Public Health."},{"key":"zoi190226r28","unstructured":"National Cancer Institute Surveillance Epidemiology and End Results Program. Definitions of single and subsequent primaries for hematologic malignancies based on ICD-O-3 reportable malignancies, effective with diagnoses 01\/01\/2001 and after. https:\/\/seer.cancer.gov\/archive\/icd-o-3\/hematopoietic_primaries.d03152001.pdf. Accessed April 2018."},{"key":"zoi190226r29","unstructured":"LinG, SoY, JohnstonG. Analyzing survival data with competing risks using SAS\u00ae software. Cary NC, SAS Institute Inc. https:\/\/support.sas.com\/resources\/papers\/proceedings12\/344-2012.pdf. Accessed March 2018."}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jamanetworkopen\/article-pdf\/2\/6\/e195536\/17635309\/chao_2019_oi_190226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T11:04:55Z","timestamp":1559905495000},"score":1,"resource":{"primary":{"URL":"http:\/\/jamanetworkopen.jamanetwork.com\/article.aspx?doi=10.1001\/jamanetworkopen.2019.5536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,7]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6,5]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.5536","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,7]]}}}