{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:13:15Z","timestamp":1789996395713,"version":"4.0.1"},"reference-count":47,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.6118","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T11:30:50Z","timestamp":1561116650000},"page":"e196118","source":"Crossref","is-referenced-by-count":28,"title":["Association of Genetic Risk for Rheumatoid Arthritis With Cognitive and Psychiatric Phenotypes Across Childhood and Adolescence"],"prefix":"10.1001","volume":"2","author":[{"given":"Hannah J.","family":"Jones","sequence":"first","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom"},{"name":"Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom"},{"name":"National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Systems Immunity University Research Institute, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom"},{"name":"The Hodge Centre for Neuropsychiatric Immunology, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Zammit","sequence":"additional","affiliation":[{"name":"Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom"},{"name":"National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, United Kingdom"},{"name":"Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Hall","sequence":"additional","affiliation":[{"name":"Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom"},{"name":"The Hodge Centre for Neuropsychiatric Immunology, Cardiff University, Cardiff, United Kingdom"},{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"issue":"10055","key":"zoi190242r1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis.","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"12","key":"zoi190242r2","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.autrev.2015.07.015","article-title":"Neuropsychiatric manifestations in rheumatoid arthritis.","volume":"14","author":"Joaquim","year":"2015","journal-title":"Autoimmun Rev"},{"issue":"6","key":"zoi190242r3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.2217\/ijr.11.62","article-title":"Depression in patients with rheumatoid arthritis: description, causes and mechanisms.","volume":"6","author":"Margaretten","year":"2011","journal-title":"Int J Clin Rheumtol"},{"issue":"1","key":"zoi190242r4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/acr.23243","article-title":"Cognitive impairment in rheumatoid arthritis: a systematic review.","volume":"70","author":"Meade","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"7","key":"zoi190242r5","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1080\/13803395.2016.1167173","article-title":"Cognitive deficits early in the course of rheumatoid arthritis.","volume":"38","author":"Simos","year":"2016","journal-title":"J Clin Exp Neuropsychol"},{"issue":"7","key":"zoi190242r6","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/acr.v70.7","article-title":"Increased burden of psychiatric disorders in rheumatoid arthritis.","volume":"70","author":"Marrie","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"9","key":"zoi190242r7","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nrrheum.2016.112","article-title":"Affective disturbance in rheumatoid arthritis: psychological and disease-related pathways.","volume":"12","author":"Sturgeon","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"zoi190242r8","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/acp.2007.116.issue-5","article-title":"Physical illness and schizophrenia: a review of the literature.","volume":"116","author":"Leucht","year":"2007","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"zoi190242r9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1176\/appi.ajp.163.3.521","article-title":"Association of schizophrenia and autoimmune diseases: linkage of Danish national registers.","volume":"163","author":"Eaton","year":"2006","journal-title":"Am J Psychiatry"},{"issue":"5","key":"zoi190242r10","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.biopsych.2015.11.024","article-title":"Attention-deficit\/hyperactivity disorder in offspring of mothers with inflammatory and immune system diseases.","volume":"81","author":"Instanes","year":"2017","journal-title":"Biol Psychiatry"},{"key":"zoi190242r11","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","article-title":"The complement system: an unexpected role in synaptic pruning during development and disease.","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu Rev Neurosci"},{"issue":"12","key":"zoi190242r12","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1038\/ni.3867","article-title":"Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior.","volume":"18","author":"Miyajima","year":"2017","journal-title":"Nat Immunol"},{"key":"zoi190242r13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.conb.2015.12.004","article-title":"New insights on the role of microglia in synaptic pruning in health and disease.","volume":"36","author":"Hong","year":"2016","journal-title":"Curr Opin Neurobiol"},{"issue":"7488","key":"zoi190242r14","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery.","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"issue":"3","key":"zoi190242r15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1001\/jamapsychiatry.2015.3058","article-title":"Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population.","volume":"73","author":"Jones","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"zoi190242r16","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1093\/schbul\/sbv168","article-title":"Evidence of common genetic overlap between schizophrenia and cognition.","volume":"42","author":"Hubbard","year":"2016","journal-title":"Schizophr Bull"},{"issue":"1","key":"zoi190242r17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S2215-0366(16)30406-0","article-title":"Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study.","volume":"4","author":"Riglin","year":"2017","journal-title":"Lancet Psychiatry"},{"issue":"1","key":"zoi190242r18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/ije\/dys064","article-title":"Cohort Profile: the \u2018children of the 90s\u2019\u2014the index offspring of the Avon Longitudinal Study of Parents and Children.","volume":"42","author":"Boyd","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"1","key":"zoi190242r19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/ije\/dys066","article-title":"Cohort profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort.","volume":"42","author":"Fraser","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"9","key":"zoi190242r21","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.","volume":"47","author":"Liu","year":"2015","journal-title":"Nat Genet"},{"issue":"7359","key":"zoi190242r22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.","volume":"476","author":"Sawcer","year":"2011","journal-title":"Nature"},{"issue":"2","key":"zoi190242r26","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1017\/S0033291700030415","article-title":"Measuring psychiatric disorder in the community: a standardized assessment for use by lay interviewers.","volume":"22","author":"Lewis","year":"1992","journal-title":"Psychol Med"},{"issue":"2","key":"zoi190242r27","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1017\/S0033291701005141","article-title":"Evidence that three dimensions of psychosis have a distribution in the general population.","volume":"32","author":"Stefanis","year":"2002","journal-title":"Psychol Med"},{"issue":"3","key":"zoi190242r28","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1192\/bjp.bp.108.051904","article-title":"IQ and non-clinical psychotic symptoms in 12-year-olds: results from the ALSPAC birth cohort.","volume":"193","author":"Horwood","year":"2008","journal-title":"Br J Psychiatry"},{"issue":"7","key":"zoi190242r29","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1176\/appi.ajp.2013.12060768","article-title":"Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study.","volume":"170","author":"Zammit","year":"2013","journal-title":"Am J Psychiatry"},{"issue":"5","key":"zoi190242r30","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/jcpp.2000.41.issue-5","article-title":"The development and well-being assessment: description and initial validation of an integrated assessment of child and adolescent psychopathology.","volume":"41","author":"Goodman","year":"2000","journal-title":"J Child Psychol Psychiatry"},{"issue":"5","key":"zoi190242r31","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/jcpp.1997.38.issue-5","article-title":"The Strengths and Difficulties Questionnaire: a research note.","volume":"38","author":"Goodman","year":"1997","journal-title":"J Child Psychol Psychiatry"},{"issue":"10","key":"zoi190242r32","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1001\/jamapsychiatry.2014.1332","article-title":"Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study.","volume":"71","author":"Khandaker","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"zoi190242r33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ynstr.2016.02.003","article-title":"Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: findings from the ALSPAC cohort.","volume":"4","author":"Khandaker","year":"2016","journal-title":"Neurobiol Stress"},{"issue":"4","key":"zoi190242r34","doi-asserted-by":"publisher","first-page":"e1004219","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data.","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"zoi190242r35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/nyas.2010.1207.issue-1","article-title":"Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials.","volume":"1207","author":"Gorelick","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"zoi190242r36","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3233\/JAD-2012-111736","article-title":"Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: a population-based study.","volume":"31","author":"Wallin","year":"2012","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"zoi190242r37","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/070674371005500602","article-title":"Poststroke depression: a review.","volume":"55","author":"Robinson","year":"2010","journal-title":"Can J Psychiatry"},{"issue":"1-3","key":"zoi190242r38","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.schres.2016.04.009","article-title":"Polygenetic components for schizophrenia, bipolar disorder and rheumatoid arthritis predict risk of schizophrenia.","volume":"175","author":"Ohi","year":"2016","journal-title":"Schizophr Res"},{"issue":"2","key":"zoi190242r39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/ajmg.b.32282","article-title":"The relationship between schizophrenia and rheumatoid arthritis revisited: genetic and epidemiological analyses.","volume":"168","author":"Euesden","year":"2015","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"5","key":"zoi190242r40","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1093\/ije\/dyv136","article-title":"New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.","volume":"44","author":"Lee","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"7589","key":"zoi190242r41","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4.","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"},{"issue":"10","key":"zoi190242r42","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.3748\/wjg.v19.i10.1611","article-title":"Cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease.","volume":"19","author":"Castaneda","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"4","key":"zoi190242r43","doi-asserted-by":"publisher","first-page":"512","DOI":"10.5009\/gnl16347","article-title":"Association of inflammatory bowel disease (IBD) with depressive symptoms in the United States population and independent predictors of depressive symptoms in an IBD population: a NHANES study.","volume":"11","author":"Bhandari","year":"2017","journal-title":"Gut Liver"},{"issue":"12","key":"zoi190242r44","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","article-title":"Cognitive impairment in multiple sclerosis.","volume":"7","author":"Chiaravalloti","year":"2008","journal-title":"Lancet Neurol"},{"issue":"6","key":"zoi190242r45","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00127-010-0219-x","article-title":"The \u2018DAWBA bands\u2019 as an ordered-categorical measure of child mental health: description and validation in British and Norwegian samples.","volume":"46","author":"Goodman","year":"2011","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"3","key":"zoi190242r46","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/03009740802448825","article-title":"Rheumatoid arthritis in UK primary care: incidence and prior morbidity.","volume":"38","author":"Rodr\u00edguez","year":"2009","journal-title":"Scand J Rheumatol"},{"issue":"4","key":"zoi190242r47","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1093\/ije\/dyy060","article-title":"Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children.","volume":"47","author":"Taylor","year":"2018","journal-title":"Int J Epidemiol"},{"key":"zoi190242r23","volume-title":"Wechsler Intelligence Scale for Children, Third UK Edition","author":"Wechsler","year":"1992"},{"key":"zoi190242r24","volume-title":"Test of Everyday Attention for Children (TEA-Ch)","author":"Manly","year":"1998"},{"key":"zoi190242r25","volume-title":"Wechsler Abbreviated Scale of Intelligence","author":"Wechsler","year":"1999"},{"key":"zoi190242r20","unstructured":"University of Bristol. Avon Longitudinal Study of Parents and Children: explore data and samples. http:\/\/www.bristol.ac.uk\/alspac\/researchers\/our-data\/. Accessed May 28, 2019."}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/\/jamanetworkopen\/article-pdf\/2\/6\/e196118\/17664683\/jones_2019_oi_190242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T11:30:52Z","timestamp":1561116652000},"score":1,"resource":{"primary":{"URL":"http:\/\/jamanetworkopen.jamanetwork.com\/article.aspx?doi=10.1001\/jamanetworkopen.2019.6118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,21]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6,5]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.6118","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,21]]}}}