{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:13:18Z","timestamp":1789913598867,"version":"4.0.1"},"reference-count":39,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2019.9826","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T11:02:25Z","timestamp":1566385345000},"page":"e199826","source":"Crossref","is-referenced-by-count":28,"title":["Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults"],"prefix":"10.1001","volume":"2","author":[{"given":"Haihao","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting Fang Alvin","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Framingham Heart Study, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Massaro","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qini","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraf","family":"Salim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya B.","family":"Kolachalama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheral","family":"Devine","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford H.","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Center, University of California Davis Medical Center, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoda","family":"Au","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Framingham Heart Study, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Alzheimer\u2019s Disease Center, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Qiao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts"},{"name":"Alzheimer\u2019s Disease Center, Boston University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"issue":"11","key":"zoi190388r1","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1210\/mend-3-11-1775","article-title":"Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history.","volume":"3","author":"Nishi","year":"1989","journal-title":"Mol Endocrinol"},{"issue":"2","key":"zoi190388r2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1463-1326.2012.01670.x","article-title":"The interaction of amylin with other hormones in the control of eating.","volume":"15","author":"Lutz","year":"2013","journal-title":"Diabetes Obes Metab"},{"key":"zoi190388r3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.physbeh.2016.02.034","article-title":"Amylin-mediated control of glycemia, energy balance, and cognition.","volume":"162","author":"Mietlicki-Baase","year":"2016","journal-title":"Physiol Behav"},{"issue":"22","key":"zoi190388r4","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/0024-3205(95)02197-Q","article-title":"Permeability of the blood-brain barrier to amylin.","volume":"57","author":"Banks","year":"1995","journal-title":"Life Sci"},{"issue":"5","key":"zoi190388r5","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S0196-9781(98)00018-7","article-title":"Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin.","volume":"19","author":"Banks","year":"1998","journal-title":"Peptides"},{"issue":"7","key":"zoi190388r6","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.peptides.2007.06.011","article-title":"Comparison of the effects of chronic central administration and chronic peripheral administration of islet amyloid polypeptide on food intake and meal pattern in the rat.","volume":"28","author":"Olsson","year":"2007","journal-title":"Peptides"},{"issue":"3","key":"zoi190388r7","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1124\/pr.115.010629","article-title":"Amylin: pharmacology, physiology, and clinical potential.","volume":"67","author":"Hay","year":"2015","journal-title":"Pharmacol Rev"},{"issue":"6","key":"zoi190388r8","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1097\/00005344-199512000-00012","article-title":"Amylin-induced relaxation of the perfused mesenteric arterial bed: meditation by calcitonin gene-related peptide receptors.","volume":"26","author":"Westfall","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"key":"zoi190388r9","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1100\/tsw.2001.23","article-title":"Amylin: localization, effects on cerebral arteries and on local cerebral blood flow in the cat.","volume":"1","author":"Edvinsson","year":"2001","journal-title":"ScientificWorldJournal"},{"issue":"12","key":"zoi190388r10","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.1210\/en.2010-0590","article-title":"Enhanced amylin-mediated body weight loss in estradiol-deficient diet-induced obese rats.","volume":"151","author":"Trevaskis","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"zoi190388r11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/MED.0b013e32835b896f","article-title":"Amylin and the regulation of appetite and adiposity: recent advances in receptor signaling, neurobiology and pharmacology.","volume":"20","author":"Roth","year":"2013","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"1","key":"zoi190388r12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1476-5381.2011.01537.x","article-title":"GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities.","volume":"166","author":"Roth","year":"2012","journal-title":"Br J Pharmacol"},{"issue":"6","key":"zoi190388r13","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1111\/jnc.1993.61.issue-6","article-title":"Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer\u2019s disease amyloid-beta neurotoxicity.","volume":"61","author":"May","year":"1993","journal-title":"J Neurochem"},{"issue":"6473","key":"zoi190388r14","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/368756a0","article-title":"Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus.","volume":"368","author":"Lorenzo","year":"1994","journal-title":"Nature"},{"issue":"2","key":"zoi190388r15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/mp.2016.35","article-title":"Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer\u2019s disease.","volume":"22","author":"Roostaei","year":"2017","journal-title":"Mol Psychiatry"},{"issue":"4","key":"zoi190388r16","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/ana.v74.4","article-title":"Amylin deposition in the brain: a second amyloid in Alzheimer disease?","volume":"74","author":"Jackson","year":"2013","journal-title":"Ann Neurol"},{"issue":"5580","key":"zoi190388r17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics.","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"issue":"22","key":"zoi190388r18","doi-asserted-by":"publisher","first-page":"18820","DOI":"10.1074\/jbc.M111.331181","article-title":"Amyloid \u00df (A\u00df) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways.","volume":"287","author":"Fu","year":"2012","journal-title":"J Biol Chem"},{"issue":"4","key":"zoi190388r19","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.neurobiolaging.2013.10.076","article-title":"Neuroprotective effects of the amylin analogue pramlintide on Alzheimer\u2019s disease pathogenesis and cognition.","volume":"35","author":"Adler","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"2","key":"zoi190388r20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/mp.2014.17","article-title":"Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer\u2019s disease.","volume":"20","author":"Zhu","year":"2015","journal-title":"Mol Psychiatry"},{"key":"zoi190388r21","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neuropharm.2017.03.030","article-title":"Amylin receptor ligands reduce the pathological cascade of Alzheimer\u2019s disease.","volume":"119","author":"Zhu","year":"2017","journal-title":"Neuropharmacology"},{"key":"zoi190388r22","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neuroscience.2017.05.024","article-title":"Amylin and its G-protein-coupled receptor: a probable pathological process and drug target for Alzheimer\u2019s disease.","volume":"356","author":"Qiu","year":"2017","journal-title":"Neuroscience"},{"issue":"21","key":"zoi190388r23","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1001\/archinte.165.21.2473","article-title":"C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.","volume":"165","author":"Wilson","year":"2005","journal-title":"Arch Intern Med"},{"issue":"3","key":"zoi190388r24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/oxfordjournals.aje.a112813","article-title":"An investigation of coronary heart disease in families: the Framingham offspring study.","volume":"110","author":"Kannel","year":"1979","journal-title":"Am J Epidemiol"},{"issue":"4","key":"zoi190388r25","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3233\/JAD-2006-9404","article-title":"Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer\u2019s disease?","volume":"9","author":"Seshadri","year":"2006","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"zoi190388r26","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.neurobiolaging.2004.05.004","article-title":"Measures of brain morphology and infarction in the Framingham Heart Study: establishing what is normal.","volume":"26","author":"DeCarli","year":"2005","journal-title":"Neurobiol Aging"},{"issue":"7","key":"zoi190388r27","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1161\/CIRCULATIONAHA.109.905091","article-title":"Cardiac index is associated with brain aging: the Framingham Heart Study.","volume":"122","author":"Jefferson","year":"2010","journal-title":"Circulation"},{"issue":"8","key":"zoi190388r28","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1161\/01.STR.30.8.1548","article-title":"Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI twin study.","volume":"30","author":"DeCarli","year":"1999","journal-title":"Stroke"},{"issue":"1","key":"zoi190388r29","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3233\/JAD-160047","article-title":"Intraneuronal amylin deposition, peroxidative membrane injury and increased IL-1\u00df synthesis in brains of Alzheimer\u2019s disease patients with type-2 diabetes and in diabetic HIP rats.","volume":"53","author":"Verma","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"zoi190388r30","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12911-014-0099-1","article-title":"Optimum binary cut-off threshold of a diagnostic test: comparison of different methods using Monte Carlo technique.","volume":"14","author":"Reibnegger","year":"2014","journal-title":"BMC Med Inform Decis Mak"},{"issue":"11","key":"zoi190388r31","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","article-title":"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.","volume":"84","author":"Westermark","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"zoi190388r32","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1006\/bbrc.1998.9308","article-title":"Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin).","volume":"250","author":"Gebre-Medhin","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"zoi190388r33","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3389\/fnagi.2014.00186","article-title":"Amylin and its analogs: a friend or foe for the treatment of Alzheimer\u2019s disease?","volume":"6","author":"Qiu","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"zoi190388r34","article-title":"Amylin\u2019s effects against A\u00df induced tauopathy and synapse loss in primary neurons.","author":"Gan","journal-title":"J Alzheimers Dis"},{"key":"zoi190388r35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuropharm.2016.07.008","article-title":"Multiple target of hAmylin on rat primary hippocampal neurons.","volume":"113","author":"Zhang","year":"2017","journal-title":"Neuropharmacology"},{"issue":"9","key":"zoi190388r36","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1172\/JCI8593","article-title":"A genetic dichotomy model for the inheritance of Alzheimer\u2019s disease and common age-related disorders.","volume":"104","author":"Tanzi","year":"1999","journal-title":"J Clin Invest"},{"issue":"2","key":"zoi190388r37","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.bbrc.2008.01.103","article-title":"Prevention and promotion effects of apolipoprotein E4 on amylin aggregation.","volume":"368","author":"Lei","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"zoi190388r38","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s001250051364","article-title":"Islet amyloid polypeptide in the islets of Langerhans: friend or foe?","volume":"43","author":"Gebre-Medhin","year":"2000","journal-title":"Diabetologia"},{"issue":"8","key":"zoi190388r39","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1210\/jc.2006-2003","article-title":"Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study.","volume":"92","author":"Aronne","year":"2007","journal-title":"J Clin Endocrinol Metab"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/article-pdf\/2\/8\/e199826\/17784533\/zhu_2019_oi_190388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T11:02:27Z","timestamp":1566385347000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2748598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.9826","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]}}}