{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:07:59Z","timestamp":1792026479789,"version":"4.4.0"},"reference-count":27,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.0129","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T11:31:01Z","timestamp":1582889461000},"page":"e200129","source":"Crossref","is-referenced-by-count":51,"title":["Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease\u2013Free Survival, and Mortality Risk"],"prefix":"10.1001","volume":"3","author":[{"given":"Benoit J.","family":"Arsenault","sequence":"first","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Perrot","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Couture","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay-Tee","family":"Khaw","sequence":"additional","affiliation":[{"name":"MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Wareham","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Molecular Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S. G.","family":"Stroes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Surgery, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Th\u00e9riault","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Matthijs","family":"Boekholdt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"issue":"1","key":"zoi200015r1","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1038\/s41467-018-05975-y","article-title":"Publisher correction: deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.","volume":"9","author":"Zekavat","year":"2018","journal-title":"Nat Commun"},{"issue":"25","key":"zoi200015r2","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1016\/j.jacc.2016.10.033","article-title":"Phenotypic characterization of genetically lowered human lipoprotein(a) levels.","volume":"68","author":"Emdin","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"zoi200015r3","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1056\/NEJMoa1109034","article-title":"Genetic associations with valvular calcification and aortic stenosis.","volume":"368","author":"Thanassoulis","year":"2013","journal-title":"N Engl J Med"},{"issue":"3","key":"zoi200015r4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1161\/CIRCGENETICS.113.000400","article-title":"Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective mendelian randomization study and replication in a case-control cohort.","volume":"7","author":"Arsenault","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"issue":"4","key":"zoi200015r5","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1001\/jama.2009.1063","article-title":"Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.","volume":"302","author":"Erqou","year":"2009","journal-title":"JAMA"},{"issue":"6","key":"zoi200015r6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1096\/fsb2.v12.6","article-title":"Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors.","volume":"12","author":"Baggio","year":"1998","journal-title":"FASEB J"},{"issue":"7","key":"zoi200015r7","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S2213-8587(17)30096-7","article-title":"Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.","volume":"5","author":"Zewinger","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"33","key":"zoi200015r8","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1093\/eurheartj\/ehy902","article-title":"High lipoprotein(a) and high risk of mortality.","volume":"40","author":"Langsted","year":"2019","journal-title":"Eur Heart J"},{"issue":"10057","key":"zoi200015r9","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/S0140-6736(16)31009-1","article-title":"Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.","volume":"388","author":"Viney","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"zoi200015r10","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1161\/CIRCRESAHA.118.312562","article-title":"Genetics of human longevity within an eco-evolutionary nature-nurture framework.","volume":"123","author":"Giuliani","year":"2018","journal-title":"Circ Res"},{"key":"zoi200015r11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39856","article-title":"Genomics of 1 million parent life spans implicates novel pathways and common diseases and distinguishes survival chances.","volume":"8","author":"Timmers","year":"2019","journal-title":"Elife"},{"issue":"1","key":"zoi200015r12","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/s41467-017-00934-5","article-title":"Genome-wide meta-analysis associates HLA-DQA1\/DRB1 and LPA and lifestyle factors with human longevity.","volume":"8","author":"Joshi","year":"2017","journal-title":"Nat Commun"},{"issue":"3","key":"zoi200015r13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age.","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"zoi200015r14","first-page":"95","article-title":"EPIC-Norfolk: study design and characteristics of the cohort: European Prospective Investigation of Cancer.","volume":"80","author":"Day","year":"1999","journal-title":"Br J Cancer"},{"issue":"12","key":"zoi200015r15","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1161\/ATVBAHA.112.255521","article-title":"Lipoprotein(a) and risk of coronary, cerebrovascular, and peripheral artery disease: the EPIC-Norfolk prospective population study.","volume":"32","author":"Gurdasani","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"zoi200015r16","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1001\/jamacardio.2018.1470","article-title":"Association of LPA variants with risk of coronary disease and the implications for lipoprotein(a)-lowering therapies: a mendelian randomization analysis.","volume":"3","author":"Burgess","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"9","key":"zoi200015r17","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1194\/jlr.M076232","article-title":"A genome-wide association meta-analysis on lipoprotein(a) concentrations adjusted for apolipoprotein(a) isoforms.","volume":"58","author":"Mack","year":"2017","journal-title":"J Lipid Res"},{"issue":"6","key":"zoi200015r18","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1001\/jamacardio.2019.1041","article-title":"Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes: a mendelian randomization analysis.","volume":"4","author":"Lamina","year":"2019","journal-title":"JAMA Cardiol"},{"issue":"3","key":"zoi200015r19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.18632\/aging.v8i3","article-title":"Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants.","volume":"8","author":"Pilling","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"zoi200015r20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s42003-019-0290-0","article-title":"Identification of 12 genetic loci associated with human healthspan.","volume":"2","author":"Zenin","year":"2019","journal-title":"Commun Biol"},{"issue":"2","key":"zoi200015r21","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"1","key":"zoi200015r22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0050012","article-title":"Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study.","volume":"5","author":"Khaw","year":"2008","journal-title":"PLoS Med"},{"issue":"9","key":"zoi200015r23","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1093\/aje\/152.9.884","article-title":"Assessing the impact of classical risk factors on myocardial infarction by rate advancement periods.","volume":"152","author":"Liese","year":"2000","journal-title":"Am J Epidemiol"},{"issue":"5","key":"zoi200015r24","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s41569-018-0153-2","article-title":"Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease.","volume":"16","author":"Boffa","year":"2019","journal-title":"Nat Rev Cardiol"},{"issue":"7709","key":"zoi200015r25","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41586-018-0198-8","article-title":"Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.","volume":"558","author":"Que","year":"2018","journal-title":"Nature"},{"issue":"8","key":"zoi200015r26","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1161\/CIRCULATIONAHA.116.020838","article-title":"Oxidized phospholipids on lipoprotein(a) elicit arterial wall inflammation and an inflammatory monocyte response in humans.","volume":"134","author":"van der Valk","year":"2016","journal-title":"Circulation"},{"issue":"7","key":"zoi200015r27","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1001\/jamacardio.2019.1581","article-title":"Genetic variation in LPA, calcific aortic valve stenosis in patients undergoing cardiac surgery, and familial risk of aortic valve microcalcification.","volume":"4","author":"Perrot","year":"2019","journal-title":"JAMA Cardiol"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2762018\/arsenault_2020_oi_200015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T11:31:04Z","timestamp":1582889464000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2762018"}},"subtitle":["A Mendelian Randomization Analysis"],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,5]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.0129","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]}}}