{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:33:07Z","timestamp":1792477987670,"version":"4.5.0"},"reference-count":31,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.13191","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T15:32:27Z","timestamp":1598542347000},"page":"e2013191","source":"Crossref","is-referenced-by-count":40,"title":["Plasma Biomarker Concentrations Associated With Return to Sport Following Sport-Related Concussion in Collegiate Athletes\u2014A Concussion Assessment, Research, and Education (CARE) Consortium Study"],"prefix":"10.1001","volume":"3","author":[{"given":"Cassandra L.","family":"Pattinson","sequence":"first","affiliation":[{"name":"National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland"},{"name":"Institute for Social Science Research, University of Queensland, Brisbane"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy B.","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian A.","family":"Guedes","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lai","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Devoto","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus","family":"Haight","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Broglio","sequence":"additional","affiliation":[{"name":"Michigan Concussion Center, University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"McAllister","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Indiana University School of Medicine, Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Giza","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Pediatrics, UCLA Steve Tisch BrainSPORT Program, University of California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Harezlak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Cameron","sequence":"additional","affiliation":[{"name":"Keller Army Community Hospital, West Point, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"McGinty","sequence":"additional","affiliation":[{"name":"United States Air Force Academy, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jackson","sequence":"additional","affiliation":[{"name":"United States Air Force Academy, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Guskiewicz","sequence":"additional","affiliation":[{"name":"Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center, Department of Exercise and Sport Science, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Mihalik","sequence":"additional","affiliation":[{"name":"Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center, Department of Exercise and Sport Science, University of North Carolina, Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Sports Medicine, School of Medicine and Public Health, University of Wisconsin\u2013Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Duma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Virginia Tech, Blacksburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Rowson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Virginia Tech, Blacksburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pasquina","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McCrea","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Gill","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CARE Consortium Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"issue":"5","key":"zoi200496r1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/00001199-200609000-00001","article-title":"The epidemiology and impact of traumatic brain injury: a brief overview.","volume":"21","author":"Langlois","year":"2006","journal-title":"J Head Trauma Rehabil"},{"issue":"7","key":"zoi200496r2","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","article-title":"Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.","volume":"68","author":"McKee","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"zoi200496r3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/bjsports-2019-100579","article-title":"Return to play and risk of repeat concussion in collegiate football players: comparative analysis from the NCAA Concussion Study (1999-2001) and CARE Consortium (2014-2017).","volume":"54","author":"McCrea","year":"2020","journal-title":"Br J Sports Med"},{"issue":"12","key":"zoi200496r4","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1136\/bjsports-2017-097791","article-title":"A systematic review of potential long-term effects of sport-related concussion.","volume":"51","author":"Manley","year":"2017","journal-title":"Br J Sports Med"},{"issue":"2","key":"zoi200496r5","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1227\/01.NEU.0000280001.03578.FF","article-title":"Differential rate of recovery in athletes after first and second concussion episodes.","volume":"61","author":"Slobounov","year":"2007","journal-title":"Neurosurgery"},{"issue":"6","key":"zoi200496r6","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1212\/WNL.0000000000003587","article-title":"Acute plasma tau relates to prolonged return to play after concussion.","volume":"88","author":"Gill","year":"2017","journal-title":"Neurology"},{"issue":"6","key":"zoi200496r7","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1001\/jamaneurol.2014.367","article-title":"Blood biomarkers for brain injury in concussed professional ice hockey players.","volume":"71","author":"Shahim","year":"2014","journal-title":"JAMA Neurol"},{"issue":"20","key":"zoi200496r8","doi-asserted-by":"publisher","first-page":"e1780","DOI":"10.1212\/WNL.0000000000005518","article-title":"Neurofilament light and tau as blood biomarkers for sports-related concussion.","volume":"90","author":"Shahim","year":"2018","journal-title":"Neurology"},{"issue":"10","key":"zoi200496r9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206466","article-title":"No change in plasma tau and serum neurofilament light concentrations in adolescent athletes following sport-related concussion.","volume":"13","author":"Wallace","year":"2018","journal-title":"PLoS One"},{"issue":"15","key":"zoi200496r10","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1212\/WNL.0000000000003816","article-title":"Astroglial activation and altered amyloid metabolism in human repetitive concussion.","volume":"88","author":"Shahim","year":"2017","journal-title":"Neurology"},{"issue":"7","key":"zoi200496r13","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1007\/s40279-017-0707-1","article-title":"A national study on the effects of concussion in collegiate athletes and us military service academy members: the NCAA-DoD Concussion Assessment, Research and Education (CARE) Consortium structure and methods.","volume":"47","author":"Broglio","year":"2017","journal-title":"Sports Med"},{"key":"zoi200496r14","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1227\/NEU.0000000000000433","article-title":"Concussion guidelines step 1: systematic review of prevalent indicators.","volume":"75","author":"Carney","year":"2014","journal-title":"Neurosurgery"},{"issue":"5","key":"zoi200496r15","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1089\/neu.2016.4496","article-title":"Serum neurofilament light protein as a marker for diffuse axonal injury: results from a case series study.","volume":"34","author":"Ljungqvist","year":"2017","journal-title":"J Neurotrauma"},{"issue":"9","key":"zoi200496r16","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment.","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J Thorac Oncol"},{"issue":"49","key":"zoi200496r17","doi-asserted-by":"publisher","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3020-14.2014","article-title":"Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.","volume":"34","author":"Iliff","year":"2014","journal-title":"J Neurosci"},{"issue":"1","key":"zoi200496r18","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/s41467-017-01068-4","article-title":"Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae.","volume":"8","author":"Albayram","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"zoi200496r19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3233\/JAD-180721","article-title":"Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges.","volume":"67","author":"Castellani","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"15","key":"zoi200496r20","doi-asserted-by":"publisher","first-page":"e1385","DOI":"10.1212\/WNL.0000000000006321","article-title":"Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI.","volume":"91","author":"Gill","year":"2018","journal-title":"Neurology"},{"issue":"23","key":"zoi200496r21","doi-asserted-by":"publisher","first-page":"e2133","DOI":"10.1212\/WNL.0000000000006617","article-title":"Concussion BASICS III: serum biomarker changes following sport-related concussion.","volume":"91","author":"Asken","year":"2018","journal-title":"Neurology"},{"issue":"1-2","key":"zoi200496r23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jns.2005.09.007","article-title":"Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome.","volume":"240","author":"Nyl\u00e9n","year":"2006","journal-title":"J Neurol Sci"},{"issue":"3","key":"zoi200496r24","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1227\/NEU.0000000000001226","article-title":"The levels of glial fibrillary acidic protein and ubiquitin c-terminal hydrolase-L1 during the first week after a traumatic brain injury: correlations with clinical and imaging findings.","volume":"79","author":"Posti","year":"2016","journal-title":"Neurosurgery"},{"issue":"11","key":"zoi200496r25","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1001\/jamaneurol.2016.2038","article-title":"Neurochemical aftermath of repetitive mild traumatic brain injury.","volume":"73","author":"Shahim","year":"2016","journal-title":"JAMA Neurol"},{"issue":"20","key":"zoi200496r26","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1089\/neu.2017.5553","article-title":"Longitudinal performance of plasma neurofilament light and tau in professional fighters: the Professional Fighters Brain Health Study.","volume":"35","author":"Bernick","year":"2018","journal-title":"J Neurotrauma"},{"issue":"8","key":"zoi200496r27","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/acn3.325","article-title":"Neurofilament light chain: a biomarker for genetic frontotemporal dementia.","volume":"3","author":"Meeter","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"issue":"19","key":"zoi200496r28","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1089\/neu.2015.4295","article-title":"Serum neurofilament light in American football athletes over the course of a season.","volume":"33","author":"Oliver","year":"2016","journal-title":"J Neurotrauma"},{"issue":"1","key":"zoi200496r29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/HTR.0000000000000485","article-title":"Elevated tau in military personnel relates to chronic symptoms following traumatic brain injury.","volume":"35","author":"Pattinson","year":"2020","journal-title":"J Head Trauma Rehabil"},{"key":"zoi200496r30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.sleep.2017.11.1121","article-title":"Elevated tau and interleukin-6 concentrations in adults with obstructive sleep apnea.","volume":"43","author":"Motamedi","year":"2018","journal-title":"Sleep Med"},{"issue":"6429","key":"zoi200496r31","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1126\/science.aav2546","article-title":"The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.","volume":"363","author":"Holth","year":"2019","journal-title":"Science"},{"key":"zoi200496r12","author":"McAllister"},{"key":"zoi200496r22","author":"McCrea"},{"key":"zoi200496r11","unstructured":"NCAA. Interassociation consensus: diagnosis and management of sport-related concussion best practices. Accessed July 19, 2019. http:\/\/www.ncaa.org\/sites\/default\/files\/SSI_ConcussionBestPractices_20170616.pdf"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2769840\/pattinson_2020_oi_200496_1602698692.37896.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T18:38:43Z","timestamp":1602700723000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2769840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,3]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.13191","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]}}}