{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:49:55Z","timestamp":1792612195304,"version":"4.5.0"},"reference-count":69,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.13211","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T01:49:44Z","timestamp":1597283384000},"page":"e2013211","source":"Crossref","is-referenced-by-count":62,"title":["Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression"],"prefix":"10.1001","volume":"3","author":[{"given":"Matthew S.","family":"Milak","sequence":"first","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rain","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengchao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Kegeles","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"},{"name":"Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Grunebaum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Todd","family":"Ogden","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"},{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Lin","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"},{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie T.","family":"Mulhern","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond F.","family":"Suckow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"},{"name":"Analytical Psychopharmacology Laboratory, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"},{"name":"Analytical Psychopharmacology Laboratory, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Keilp","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangling","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dikoma C.","family":"Shungu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. John","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York"},{"name":"Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York"},{"name":"Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"issue":"2","key":"zoi200499r3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4088\/JCP.14m09298","article-title":"The economic burden of adults with major depressive disorder in the United States (2005 and 2010).","volume":"76","author":"Greenberg","year":"2015","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"zoi200499r4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1176\/appi.ajp.2008.08071027","article-title":"Can phase III trial results of antidepressant medications be generalized to clinical practice? a STAR*D report.","volume":"166","author":"Wisniewski","year":"2009","journal-title":"Am J Psychiatry"},{"issue":"2","key":"zoi200499r5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0193-953X(05)70283-5","article-title":"Definition and epidemiology of treatment-resistant depression.","volume":"19","author":"Fava","year":"1996","journal-title":"Psychiatr Clin North Am"},{"key":"zoi200499r6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.neubiorev.2017.08.019","article-title":"Treatment resistant depression: a multi-scale, systems biology approach.","volume":"84","author":"Akil","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"zoi200499r7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients.","volume":"47","author":"Berman","year":"2000","journal-title":"Biol Psychiatry"},{"issue":"2","key":"zoi200499r8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.biopsych.2008.09.029","article-title":"Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist.","volume":"65","author":"Phelps","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"1","key":"zoi200499r9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1017\/S1461145709000169","article-title":"Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial.","volume":"13","author":"Mathew","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"zoi200499r10","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/00000539-200207000-00020","article-title":"Small-dose ketamine improves the postoperative state of depressed patients.","volume":"95","author":"Kudoh","year":"2002","journal-title":"Anesth Analg"},{"issue":"8","key":"zoi200499r11","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"zoi200499r12","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.biopsych.2009.04.029","article-title":"Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression.","volume":"66","author":"Price","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"3","key":"zoi200499r13","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1017\/S0033291715002159","article-title":"Single IV ketamine augmentation of newly initiated escitalopram for major depression: results from a randomized, placebo-controlled 4-week study.","volume":"46","author":"Hu","year":"2016","journal-title":"Psychol Med"},{"issue":"6","key":"zoi200499r14","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.biopsych.2015.10.018","article-title":"Intravenous esketamine in adult treatment-resistant depression: a double-blind, double-randomization, placebo-controlled study.","volume":"80","author":"Singh","year":"2016","journal-title":"Biol Psychiatry"},{"issue":"8","key":"zoi200499r15","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1176\/appi.ajp.2016.16010037","article-title":"A double-blind, randomized, placebo-controlled, dose-frequency study of intravenous ketamine in patients with treatment-resistant depression.","volume":"173","author":"Singh","year":"2016","journal-title":"Am J Psychiatry"},{"issue":"10","key":"zoi200499r16","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1176\/appi.ajp.2013.13030392","article-title":"Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.","volume":"170","author":"Murrough","year":"2013","journal-title":"Am J Psychiatry"},{"issue":"12","key":"zoi200499r17","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.4088\/JCP.09m05327blu","article-title":"Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder.","volume":"71","author":"DiazGranados","year":"2010","journal-title":"J Clin Psychiatry"},{"issue":"4","key":"zoi200499r18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1176\/appi.ajp.2017.17060647","article-title":"Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial.","volume":"175","author":"Grunebaum","year":"2018","journal-title":"Am J Psychiatry"},{"issue":"3","key":"zoi200499r19","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/bdi.2017.19.issue-3","article-title":"Ketamine versus midazolam in bipolar depression with suicidal thoughts: a pilot midazolam-controlled randomized clinical trial.","volume":"19","author":"Grunebaum","year":"2017","journal-title":"Bipolar Disord"},{"issue":"10","key":"zoi200499r20","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1176\/appi.ajp.2015.15040465","article-title":"Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression.","volume":"172","author":"Newport","year":"2015","journal-title":"Am J Psychiatry"},{"issue":"4","key":"zoi200499r21","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1001\/jamapsychiatry.2017.0080","article-title":"A consensus statement on the use of ketamine in the treatment of mood disorders.","volume":"74","author":"Sanacora","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"10","key":"zoi200499r22","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1002\/nbm.1681","article-title":"In vivo and ex vivo evidence for ketamine-induced hyperglutamatergic activity in the cerebral cortex of the rat: potential relevance to schizophrenia.","volume":"24","author":"Kim","year":"2011","journal-title":"NMR Biomed"},{"issue":"8","key":"zoi200499r23","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1523\/JNEUROSCI.17-08-02921.1997","article-title":"Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.","volume":"17","author":"Moghaddam","year":"1997","journal-title":"J Neurosci"},{"issue":"3","key":"zoi200499r24","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/mp.2015.83","article-title":"A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder.","volume":"21","author":"Milak","year":"2016","journal-title":"Mol Psychiatry"},{"key":"zoi200499r25","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bbr.2014.05.065","article-title":"Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats.","volume":"271","author":"Koike","year":"2014","journal-title":"Behav Brain Res"},{"issue":"1","key":"zoi200499r26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression.","volume":"224","author":"Koike","year":"2011","journal-title":"Behav Brain Res"},{"issue":"4","key":"zoi200499r27","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol Psychiatry"},{"issue":"7604","key":"zoi200499r28","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites.","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"},{"issue":"1","key":"zoi200499r29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/03009734.2012.724118","article-title":"Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test.","volume":"118","author":"Yang","year":"2013","journal-title":"Ups J Med Sci"},{"issue":"5994","key":"zoi200499r30","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"issue":"11","key":"zoi200499r31","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1176\/appi.ajp.2012.12040531","article-title":"Synaptic mechanisms underlying rapid antidepressant action of ketamine.","volume":"169","author":"Kavalali","year":"2012","journal-title":"Am J Psychiatry"},{"issue":"12","key":"zoi200499r32","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.biopsych.2012.09.006","article-title":"The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine.","volume":"73","author":"Monteggia","year":"2013","journal-title":"Biol Psychiatry"},{"issue":"2","key":"zoi200499r33","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1017\/S1461145707007924","article-title":"Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients.","volume":"11","author":"Bhagwagar","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"issue":"2","key":"zoi200499r34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1001\/archpsyc.64.2.193","article-title":"Reduced prefrontal glutamate\/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy.","volume":"64","author":"Hasler","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"7","key":"zoi200499r35","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1001\/archpsyc.61.7.705","article-title":"Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.","volume":"61","author":"Sanacora","year":"2004","journal-title":"Arch Gen Psychiatry"},{"issue":"11","key":"zoi200499r36","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1001\/archpsyc.56.11.1043","article-title":"Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy.","volume":"56","author":"Sanacora","year":"1999","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"zoi200499r37","first-page":"233","article-title":"Decreased occipital GABA concentrations in patients with first-episode major depressive disorder: a magnetic resonance spectroscopy study.","volume":"29","author":"Song","year":"2012","journal-title":"Sheng Wu Yi Xue Gong Cheng Xue Za Zhi"},{"issue":"2","key":"zoi200499r38","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/JCP.0b013e3181d20912","article-title":"Site versus centralized raters in a clinical depression trial: impact on patient selection and placebo response.","volume":"30","author":"Kobak","year":"2010","journal-title":"J Clin Psychopharmacol"},{"issue":"1","key":"zoi200499r39","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1177\/009286150003400120","article-title":"Computer assessment of depression: automating the Hamilton Depression Rating Scale.","volume":"34","author":"Kobak","year":"2000","journal-title":"Drug Inf J"},{"issue":"7","key":"zoi200499r40","doi-asserted-by":"publisher","first-page":"637","DOI":"10.2174\/156720510793499057","article-title":"Inaccuracy in clinical trials: effects and methods to control inaccuracy.","volume":"7","author":"Kobak","year":"2010","journal-title":"Curr Alzheimer Res"},{"key":"zoi200499r41","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials.","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"3","key":"zoi200499r42","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms.","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol Rev"},{"issue":"12","key":"zoi200499r43","doi-asserted-by":"publisher","first-page":"5662","DOI":"10.1073\/pnas.90.12.5662","article-title":"Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.","volume":"90","author":"Rothman","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"zoi200499r44","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/nbm.v29.7","article-title":"Brain ?-aminobutyric acid (GABA) detection in vivo with the J-editing (1) H MRS technique: a comprehensive methodological evaluation of sensitivity enhancement, macromolecule contamination and test-retest reliability.","volume":"29","author":"Shungu","year":"2016","journal-title":"NMR Biomed"},{"issue":"7","key":"zoi200499r45","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.jpsychires.2013.02.015","article-title":"Ketamine, magnesium and major depression\u2014from pharmacology to pathophysiology and back.","volume":"47","author":"Murck","year":"2013","journal-title":"J Psychiatr Res"},{"issue":"3","key":"zoi200499r46","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/bja\/47.3.336","article-title":"The effects of magnesium deficiency of ketamine sleeping times in the rat.","volume":"47","author":"Douglas","year":"1975","journal-title":"Br J Anaesth"},{"issue":"6","key":"zoi200499r47","first-page":"580","article-title":"Magnesium intake and depression.","volume":"43","author":"Wilson","year":"2009","journal-title":"Aust N Z J Psychiatry"},{"issue":"5","key":"zoi200499r48","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1179\/1476830512Y.0000000044","article-title":"Magnesium and depression: a systematic review.","volume":"16","author":"Derom","year":"2013","journal-title":"Nutr Neurosci"},{"issue":"6","key":"zoi200499r49","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3945\/jn.111.155572","article-title":"Magnesium intake is not related to depression risk in Spanish university graduates.","volume":"142","author":"Derom","year":"2012","journal-title":"J Nutr"},{"issue":"2","key":"zoi200499r50","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1037\/0021-9010.69.2.307","article-title":"Mediators, moderators, and tests for mediation.","volume":"69","author":"James","year":"1984","journal-title":"J Appl Psychol"},{"issue":"5","key":"zoi200499r51","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1177\/0193841X8100500502","article-title":"Process analysis\u2014estimating mediation in treatment evaluations.","volume":"5","author":"Judd","year":"1981","journal-title":"Eval Rev"},{"issue":"6","key":"zoi200499r52","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.","volume":"51","author":"Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"issue":"4","key":"zoi200499r53","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv124","article-title":"Effects of low-dose and very low-dose ketamine among patients with major depression: a systematic review and meta-analysis.","volume":"19","author":"Xu","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"key":"zoi200499r54","article-title":"Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD).","author":"Fava","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"7659","key":"zoi200499r55","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1038\/nature22084","article-title":"Effects of a ketamine metabolite on synaptic NMDAR function.","volume":"546","author":"Suzuki","year":"2017","journal-title":"Nature"},{"issue":"1","key":"zoi200499r56","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1016\/j.biopsych.2017.10.020","article-title":"Common neurotransmission recruited in (R,S)-ketamine and (2R,6R)-hydroxynorketamine-induced sustained antidepressant-like effects.","volume":"84","author":"Pham","year":"2018","journal-title":"Biol Psychiatry"},{"issue":"4","key":"zoi200499r57","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/mp.2017.58","article-title":"Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression.","volume":"23","author":"Esterlis","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"3","key":"zoi200499r58","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0306-4522(02)00652-8","article-title":"Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.","volume":"117","author":"Lorrain","year":"2003","journal-title":"Neuroscience"},{"issue":"3","key":"zoi200499r59","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/sj.npp.1301057","article-title":"Ketamine, at a dose that disrupts motor behavior and latent inhibition, enhances prefrontal cortex synaptic efficacy and glutamate release in the nucleus accumbens.","volume":"32","author":"Razoux","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"zoi200499r60","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.biopsych.2013.03.026","article-title":"Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.","volume":"73","author":"Krystal","year":"2013","journal-title":"Biol Psychiatry"},{"issue":"3","key":"zoi200499r61","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.conb.2006.05.008","article-title":"Novel presynaptic mechanisms for coincidence detection in synaptic plasticity.","volume":"16","author":"Duguid","year":"2006","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"zoi200499r62","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuropharm.2011.08.044","article-title":"Signaling pathways underlying the rapid antidepressant actions of ketamine.","volume":"62","author":"Duman","year":"2012","journal-title":"Neuropharmacology"},{"issue":"12","key":"zoi200499r63","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1002\/nbm.v26.12","article-title":"Glutamate and glutamine: a review of in vivo MRS in the human brain.","volume":"26","author":"Ramadan","year":"2013","journal-title":"NMR Biomed"},{"issue":"9","key":"zoi200499r64","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1038\/npp.2013.61","article-title":"Acute shift in glutamate concentrations following experimentally induced panic with cholecystokinin tetrapeptide\u2014a 3T-MRS study in healthy subjects.","volume":"38","author":"Zwanzger","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"6436","key":"zoi200499r65","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat8078","article-title":"Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.","volume":"364","author":"Moda-Sava","year":"2019","journal-title":"Science"},{"issue":"3","key":"zoi200499r66","first-page":"228","article-title":"Rapid and sustained antidepressant action of the mGlu2\/3 Receptor antagonist MGS0039 in the social defeat stress model: comparison with ketamine.","volume":"20","author":"Dong","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"zoi200499r67","doi-asserted-by":"publisher","first-page":"15788","DOI":"10.1038\/s41598-017-16183-x","article-title":"Ketamine\u2019s antidepressant effect is mediated by energy metabolism and antioxidant defense system.","volume":"7","author":"Weckmann","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"zoi200499r68","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.biopsych.2017.05.016","article-title":"Mechanistic target of rapamycin-independent antidepressant effects of (R)-ketamine in a social defeat stress model.","volume":"83","author":"Yang","year":"2018","journal-title":"Biol Psychiatry"},{"issue":"9","key":"zoi200499r69","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.biopsych.2015.04.022","article-title":"Ketamine as a prophylactic against stress-induced depressive-like behavior.","volume":"79","author":"Brachman","year":"2016","journal-title":"Biol Psychiatry"},{"key":"zoi200499r2","volume-title":"Major Depression Among Adults","author":"National Institute of Mental Health","year":"2015"},{"key":"zoi200499r1","unstructured":"World Health Organization. Depression and other common mental disorders: global health estimates. Accessed July 13, 2020. https:\/\/www.who.int\/mental_health\/management\/depression\/prevalence_global_health_estimates\/en\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2769233\/milak_2020_oi_200499.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T19:31:37Z","timestamp":1667763097000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2769233"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2020,8,12]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8,3]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.13211","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,12]]}}}