{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:43:10Z","timestamp":1779334990463,"version":"3.51.4"},"reference-count":21,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.1357","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T15:31:09Z","timestamp":1584977469000},"page":"e201357","source":"Crossref","is-referenced-by-count":17,"title":["Assessment of Thyroid Function in Patients With Alkaptonuria"],"prefix":"10.1001","volume":"3","author":[{"given":"Shirisha","family":"Avadhanula","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"},{"name":"National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy J.","family":"Introne","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungyoung","family":"Auh","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Soldin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Stolze","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Regier","sequence":"additional","affiliation":[{"name":"Children\u2019s National Rare Disease Institute, Children\u2019s National Medical Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Ciccone","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady","family":"Hannah-Shmouni","sequence":"additional","affiliation":[{"name":"National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando C.","family":"Filie","sequence":"additional","affiliation":[{"name":"National Cancer Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Burman","sequence":"additional","affiliation":[{"name":"Endocrine Section, Medstar Washington Hospital Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Klubo-Gwiezdzinska","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"issue":"2","key":"zoi200074r2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1034\/j.1399-0004.2003.00027.x","article-title":"Rapid detection methods for five HGO gene mutations causing alkaptonuria.","volume":"63","author":"Zatkova","year":"2003","journal-title":"Clin Genet"},{"issue":"1","key":"zoi200074r3","first-page":"41","article-title":"Alkaptonuric ochronosis: a case report.","volume":"73","author":"Collins","year":"2005","journal-title":"AANA J"},{"issue":"4","key":"zoi200074r4","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1053\/j.jvca.2008.08.014","article-title":"The inability of regional oxygen saturation monitoring in a patient with alkaptonuria undergoing aortic valve replacement.","volume":"23","author":"Argiriadou","year":"2009","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"zoi200074r5","article-title":"Alkaptonuria.","volume":"1","author":"Mistry","year":"2013","journal-title":"Rare Dis"},{"issue":"2","key":"zoi200074r6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00296-004-0498-1","article-title":"New developments in ochronosis: review of the literature.","volume":"25","author":"Keller","year":"2005","journal-title":"Rheumatol Int"},{"issue":"26","key":"zoi200074r7","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1056\/NEJMoa021736","article-title":"Natural history of alkaptonuria.","volume":"347","author":"Phornphutkul","year":"2002","journal-title":"N Engl J Med"},{"issue":"3","key":"zoi200074r8","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1086\/302027","article-title":"NTBC and alkaptonuria.","volume":"63","author":"Anikster","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"4","key":"zoi200074r9","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ymgme.2011.04.016","article-title":"A 3-year randomized therapeutic trial of nitisinone in alkaptonuria.","volume":"103","author":"Introne","year":"2011","journal-title":"Mol Genet Metab"},{"issue":"12","key":"zoi200074r10","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1089\/thy.2006.0235","article-title":"Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002).","volume":"17","author":"Aoki","year":"2007","journal-title":"Thyroid"},{"issue":"4","key":"zoi200074r11","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archinte.160.4.526","article-title":"The Colorado thyroid disease prevalence study.","volume":"160","author":"Canaris","year":"2000","journal-title":"Arch Intern Med"},{"issue":"10101","key":"zoi200074r12","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/S0140-6736(17)30703-1","article-title":"Hypothyroidism.","volume":"390","author":"Chaker","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"zoi200074r13","doi-asserted-by":"publisher","first-page":"988","DOI":"10.4158\/EP12280.GL","article-title":"Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association.","volume":"18","author":"Garber","year":"2012","journal-title":"Endocr Pract"},{"issue":"10","key":"zoi200074r14","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis.","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"issue":"3","key":"zoi200074r15","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/cen.2015.83.issue-3","article-title":"US not bright but right method of thyroid volume estimation even in large and substernal extended goiters: comparison of US and three methods of CT thyroid evaluation\u2014prospective study.","volume":"83","author":"Kaniuka-Jakubowska","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"zoi200074r16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/978-3-662-48227-8","article-title":"The pigment in alkaptonuria relationship to melanin and other coloured substances: a review of metabolism, composition and chemical analysis.","volume":"24","author":"Roberts","year":"2015","journal-title":"JIMD Rep"},{"issue":"11","key":"zoi200074r17","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/BF03347788","article-title":"Prevalence of anti-thyroid peroxidase antibodies in autoimmune and nonautoimmune thyroid disorders in a relatively low-iodine environment.","volume":"17","author":"Knobel","year":"1994","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"zoi200074r18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"issue":"2","key":"zoi200074r19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.18544\/PEDM-22.02.0054","article-title":"Alkaptonuria in a boy with type 1 diabetes mellitus, vitiligo, autoimmune thyroiditis and immunoglobulin A deficiency\u2014a case report.","volume":"22","author":"Hogendorf","year":"2016","journal-title":"Pediatr Endocrinol Diabetes Metab"},{"issue":"2","key":"zoi200074r20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4103\/0970-9185.81839","article-title":"Perioperative management of patient with alkaptonuria and associated multiple comorbidities.","volume":"27","author":"Pandey","year":"2011","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"12","key":"zoi200074r21","doi-asserted-by":"publisher","first-page":"e1141","DOI":"10.3928\/01477447-20141123-94","article-title":"Alkaptonuric ochronosis.","volume":"37","author":"Lal","year":"2014","journal-title":"Orthopedics"},{"key":"zoi200074r1","volume-title":"GeneReviews","author":"Introne","year":"1993"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2763227\/avadhanula_2020_oi_200074.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T15:31:10Z","timestamp":1584977470000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2763227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.1357","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]}}}