{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:13:26Z","timestamp":1793121206160,"version":"4.5.0"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.15665","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T19:13:09Z","timestamp":1602529989000},"page":"e2015665","source":"Crossref","is-referenced-by-count":171,"title":["Trends in the Incidence of Central Precocious Puberty and Normal Variant Puberty Among Children in Denmark, 1998 to 2017"],"prefix":"10.1001","volume":"3","author":[{"given":"Elvira V.","family":"Br\u00e4uner","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Eckert-Lind","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"issue":"5","key":"zoi200583r1","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1210\/er.2002-0019","article-title":"The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration.","volume":"24","author":"Parent","year":"2003","journal-title":"Endocr Rev"},{"key":"zoi200583r2","doi-asserted-by":"publisher","first-page":"11208","DOI":"10.1038\/srep11208","article-title":"Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study.","volume":"5","author":"Day","year":"2015","journal-title":"Sci Rep"},{"issue":"11","key":"zoi200583r3","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.2337\/dc13-0446","article-title":"Age at menarche and type 2 diabetes risk: the EPIC-InterAct study.","volume":"36","author":"Elks","year":"2013","journal-title":"Diabetes Care"},{"issue":"8","key":"zoi200583r4","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/ijo.2012.177","article-title":"Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis.","volume":"37","author":"Prentice","year":"2013","journal-title":"Int J Obes (Lond)"},{"issue":"8","key":"zoi200583r5","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1210\/jc.2011-3445","article-title":"Timing of voice breaking in males associated with growth and weight gain across the life course.","volume":"97","author":"Ong","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"zoi200583r6","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s10802-013-9798-9","article-title":"Early pubertal timing as a vulnerability to depression symptoms: differential effects of race and sex.","volume":"42","author":"Hamlat","year":"2014","journal-title":"J Abnorm Child Psychol"},{"issue":"1","key":"zoi200583r7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/aje\/kwu113","article-title":"Age at menarche and risks of all-cause and cardiovascular death: a systematic review and meta-analysis.","volume":"180","author":"Charalampopoulos","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"6","key":"zoi200583r8","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/ng.3841","article-title":"Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.","volume":"49","author":"Day","year":"2017","journal-title":"Nat Genet"},{"key":"zoi200583r9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12916-016-0602-x","article-title":"Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.","volume":"14","author":"Bonilla","year":"2016","journal-title":"BMC Med"},{"issue":"4","key":"zoi200583r10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1542\/peds.99.4.505","article-title":"Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network.","volume":"99","author":"Herman-Giddens","year":"1997","journal-title":"Pediatrics"},{"issue":"4 Pt 1","key":"zoi200583r11","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1542\/peds.104.4.936","article-title":"Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment.","volume":"104","author":"Kaplowitz","year":"1999","journal-title":"Pediatrics"},{"issue":"4","key":"zoi200583r12","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1542\/peds.110.4.752","article-title":"Ethnic differences in the presence of secondary sex characteristics and menarche among US girls: the Third National Health and Nutrition Examination Survey, 1988-1994.","volume":"110","author":"Wu","year":"2002","journal-title":"Pediatrics"},{"issue":"5","key":"zoi200583r13","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1542\/peds.110.5.911","article-title":"National estimates of the timing of sexual maturation and racial differences among US children.","volume":"110","author":"Sun","year":"2002","journal-title":"Pediatrics"},{"issue":"9","key":"zoi200583r14","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1001\/archpedi.155.9.1022","article-title":"Secondary sexual characteristics in boys: estimates from the National Health and Nutrition Examination Survey III, 1988-1994.","volume":"155","author":"Herman-Giddens","year":"2001","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"1","key":"zoi200583r15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/ija.2006.29.issue-1","article-title":"Pubertal development in Danish children: comparison of recent European and US data.","volume":"29","author":"Juul","year":"2006","journal-title":"Int J Androl"},{"issue":"4","key":"zoi200583r16","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1203\/00006450-200110000-00010","article-title":"Pubertal development in the Netherlands 1965-1997.","volume":"50","author":"Mul","year":"2001","journal-title":"Pediatr Res"},{"issue":"5","key":"zoi200583r17","doi-asserted-by":"publisher","first-page":"e932","DOI":"10.1542\/peds.2008-2491","article-title":"Recent decline in age at breast development: the Copenhagen Puberty Study.","volume":"123","author":"Aksglaede","year":"2009","journal-title":"Pediatrics"},{"issue":"5","key":"zoi200583r18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/ppe.2009.23.issue-5","article-title":"Timing of maturation and predictors of menarche in girls enrolled in a contemporary British cohort.","volume":"23","author":"Rubin","year":"2009","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"1","key":"zoi200583r19","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1210\/jc.2009-1478","article-title":"Recent changes in pubertal timing in healthy Danish boys: associations with body mass index.","volume":"95","author":"S\u00f8rensen","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"zoi200583r20","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1210\/jc.2010-2745","article-title":"Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty.","volume":"96","author":"Mogensen","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"22","key":"zoi200583r21","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Clinical practice\u2014precocious puberty.","volume":"358","author":"Carel","year":"2008","journal-title":"N Engl J Med"},{"issue":"6","key":"zoi200583r22","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1542\/peds.2005-0012","article-title":"Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries.","volume":"116","author":"Teilmann","year":"2005","journal-title":"Pediatrics"},{"key":"zoi200583r23","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fendo.2017.00213","article-title":"Precocious puberty or premature thelarche: analysis of a large patient series in a single tertiary center with special emphasis on 6- to 8-year-old girls.","volume":"8","author":"Varimo","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"zoi200583r24","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.1210\/jc.2010-1025","article-title":"Central precocious puberty in children living in Spain: incidence, prevalence, and influence of adoption and immigration.","volume":"95","author":"Soriano-Guill\u00e9n","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"zoi200583r25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1530\/EJE-17-0379","article-title":"Marked geographic patterns in the incidence of idiopathic central precocious puberty: a nationwide study in France.","volume":"178","author":"Le Moal","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"zoi200583r26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141844","article-title":"A significant increase in the incidence of central precocious puberty among Korean girls from 2004 to 2010.","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"zoi200583r27","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jpeds.2018.12.022","article-title":"Incidence and prevalence of central precocious puberty in Korea: an epidemiologic study based on a national database.","volume":"208","author":"Kim","year":"2019","journal-title":"J Pediatr"},{"key":"zoi200583r28","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2019.5881","article-title":"Worldwide secular trends in age at pubertal onset assessed by breast development among girls: a systematic review and meta-analysis.","author":"Eckert-Lind","year":"2020","journal-title":"JAMA Pediatr"},{"issue":"20","key":"zoi200583r29","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"issue":"9596","key":"zoi200583r30","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"zoi200583r31","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2147\/CLEP","article-title":"The Danish health care system and epidemiological research: from health care contacts to database records.","volume":"11","author":"Schmidt","year":"2019","journal-title":"Clin Epidemiol"},{"issue":"8","key":"zoi200583r32","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1111\/j.1651-2227.1997.tb08602.x","article-title":"Longitudinal study of behavioral and affective patterns in girls with central precocious puberty during long-acting triptorelin therapy.","volume":"86","author":"Xhrouet-Heinrichs","year":"1997","journal-title":"Acta Paediatr"},{"issue":"5","key":"zoi200583r34","first-page":"739","article-title":"Common genetic influences on BMI and age at menarche.","volume":"67","author":"Kaprio","year":"1995","journal-title":"Hum Biol"},{"issue":"12","key":"zoi200583r35","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/ng.714","article-title":"Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.","volume":"42","author":"Elks","year":"2010","journal-title":"Nat Genet"},{"issue":"9","key":"zoi200583r36","first-page":"63","article-title":"Limited availability of childhood overweight and obesity treatment programmes in Danish paediatric departments.","volume":"63","author":"Eg","year":"2016","journal-title":"Dan Med J"},{"issue":"10","key":"zoi200583r37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/ijerph14101266","article-title":"Association between obesity and puberty timing: a systematic review and meta-analysis.","volume":"14","author":"Li","year":"2017","journal-title":"Int J Environ Res Public Health"},{"key":"zoi200583r38","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2019.2315","article-title":"Secular trends in pubertal growth acceleration in Swedish boys born from 1947 to 1996.","author":"Ohlsson","year":"2019","journal-title":"JAMA Pediatr"},{"key":"zoi200583r33","unstructured":"Statistics Denmark. Accessed September 14, 2020. https:\/\/www.statistikbanken.dk\/statbank5a\/default.asp?w=1920"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2771377\/bruner_2020_oi_200583_1601396084.63405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T19:13:19Z","timestamp":1602529999000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2771377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.15665","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]}}}