{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:33:49Z","timestamp":1788042829232,"version":"build-2784847793"},"reference-count":70,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.27584","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T12:49:42Z","timestamp":1606826982000},"page":"e2027584","source":"Crossref","is-referenced-by-count":25,"title":["Cost-effectiveness of Screening for Osteoporosis in Older Men With a History of Falls"],"prefix":"10.1001","volume":"3","author":[{"given":"Kouta","family":"Ito","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester"},{"name":"Meyers Primary Care Institute, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"issue":"1","key":"zoi200889r1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/jgs.v68.1","article-title":"AGS and NIA bench-to bedside conference summary: osteoporosis and soft tissue (muscle and fat) disorders.","volume":"68","author":"Col\u00f3n-Emeric","year":"2020","journal-title":"J Am Geriatr Soc"},{"issue":"37","key":"zoi200889r2","doi-asserted-by":"publisher","first-page":"993","DOI":"10.15585\/mmwr.mm6537a2","article-title":"Falls and fall injuries among adults aged =65 years\u2014United States, 2014.","volume":"65","author":"Bergen","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"11","key":"zoi200889r3","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1002\/jbmr.2269","article-title":"The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine.","volume":"29","author":"Wright","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"10","key":"zoi200889r4","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1007\/s00198-013-2375-9","article-title":"The impact of decreasing US hip fracture rates on future hip fracture estimates.","volume":"24","author":"Stevens","year":"2013","journal-title":"Osteoporos Int"},{"issue":"3","key":"zoi200889r5","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s002239900679","article-title":"Majority of hip fractures occur as a result of a fall and impact on the greater trochanter of the femur: a prospective controlled hip fracture study with 206 consecutive patients.","volume":"65","author":"Parkkari","year":"1999","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"zoi200889r6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00198-015-3295-7","article-title":"FRAX predicts incident falls in elderly men: findings from MrOs Sweden.","volume":"27","author":"Harvey","year":"2016","journal-title":"Osteoporos Int"},{"issue":"2","key":"zoi200889r7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00198-017-4277-8","article-title":"The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr OS and Ms OS cohort study in Hong Kong.","volume":"29","author":"Su","year":"2018","journal-title":"Osteoporos Int"},{"issue":"11","key":"zoi200889r8","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s00198-019-05106-3","article-title":"Fracture prediction from self-reported falls in routine clinical practice: a registry-based cohort study.","volume":"30","author":"Leslie","year":"2019","journal-title":"Osteoporos Int"},{"issue":"3","key":"zoi200889r9","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/jbmr.v33.3","article-title":"Falls predict fractures independently of FRAX probability: a meta-analysis of the Osteoporotic Fractures in Men (MrOS) study.","volume":"33","author":"Harvey","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"1","key":"zoi200889r11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/jgs.2011.59.issue-1","article-title":"Summary of the Updated American Geriatrics Society\/British Geriatrics Society clinical practice guideline for prevention of falls in older persons.","volume":"59","author":"Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society","year":"2011","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"zoi200889r13","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1210\/jc.2011-3045","article-title":"Osteoporosis in men: an Endocrine Society clinical practice guideline.","volume":"97","author":"Watts","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"zoi200889r14","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s00198-014-2794-2","article-title":"Clinician\u2019s guide to prevention and treatment for osteoporosis.","volume":"25","author":"Cosman","year":"2014","journal-title":"Osteoporos Int"},{"issue":"12","key":"zoi200889r18","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.mayocp.2018.06.024","article-title":"Limited osteoporosis screening effectiveness due to low treatment rates in national sample of older men.","volume":"93","author":"Col\u00f3n-Emeric","year":"2018","journal-title":"Mayo Clin Proc"},{"issue":"10122","key":"zoi200889r19","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S0140-6736(17)32640-5","article-title":"Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial.","volume":"391","author":"Shepstone","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"zoi200889r20","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00198-017-4326-3","article-title":"Effectiveness of a two-step population-based osteoporosis screening program using FRAX: the randomized Risk-Stratified Osteoporosis Strategy Evaluation (ROSE) study.","volume":"29","author":"Rubin","year":"2018","journal-title":"Osteoporos Int"},{"issue":"11","key":"zoi200889r21","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1002\/jbmr.v34.11","article-title":"The effect of a screening and treatment program for the prevention of fractures in older women: a randomized pragmatic trial.","volume":"34","author":"Merlijn","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"2","key":"zoi200889r22","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00198-019-05226-w","article-title":"Fracture prevention by screening for high fracture risk: a systematic review and meta-analysis.","volume":"31","author":"Merlijn","year":"2020","journal-title":"Osteoporos Int"},{"issue":"6","key":"zoi200889r23","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1001\/jama.298.6.629","article-title":"Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older men.","volume":"298","author":"Schousboe","year":"2007","journal-title":"JAMA"},{"issue":"2","key":"zoi200889r24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/(ISSN)1532-5415","article-title":"Using the osteoporosis self-assessment tool for referring older men for bone densitometry: a decision analysis.","volume":"57","author":"Ito","year":"2009","journal-title":"J Am Geriatr Soc"},{"issue":"10","key":"zoi200889r25","doi-asserted-by":"publisher","first-page":"621","DOI":"10.7326\/0003-4819-152-10-201005180-00002","article-title":"Cost-effectiveness of fracture prevention in men who receive androgen deprivation therapy for localized prostate cancer.","volume":"152","author":"Ito","year":"2010","journal-title":"Ann Intern Med"},{"issue":"6","key":"zoi200889r26","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/jbmr.2784","article-title":"Cost-effectiveness of osteoporosis screening strategies for men.","volume":"31","author":"Nayak","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"1","key":"zoi200889r27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00198-018-4744-x","article-title":"Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts\u2019 consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the US branch of the International Osteoporosis Foundation.","volume":"30","author":"Hiligsmann","year":"2019","journal-title":"Osteoporos Int"},{"issue":"2","key":"zoi200889r29","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jval.2013.02.010","article-title":"Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement.","volume":"16","author":"Husereau","year":"2013","journal-title":"Value Health"},{"issue":"3","key":"zoi200889r30","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.bone.2007.11.001","article-title":"A reference standard for the description of osteoporosis.","volume":"42","author":"Kanis","year":"2008","journal-title":"Bone"},{"issue":"4","key":"zoi200889r31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00198-007-0550-6","article-title":"Cost-effective osteoporosis treatment thresholds: the United States perspective.","volume":"19","author":"Tosteson","year":"2008","journal-title":"Osteoporos Int"},{"issue":"251","key":"zoi200889r32","first-page":"1","article-title":"Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: United States, 2005-2008.","volume":"251","author":"Looker","year":"2012","journal-title":"Vital Health Stat 11"},{"issue":"7","key":"zoi200889r33","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures.","volume":"20","author":"Johnell","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"2","key":"zoi200889r34","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bone.2004.03.024","article-title":"A meta-analysis of previous fracture and subsequent fracture risk.","volume":"35","author":"Kanis","year":"2004","journal-title":"Bone"},{"issue":"3","key":"zoi200889r35","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/jgs.14668","article-title":"Osteoporosis treatment efficacy for men: a systematic review and meta-analysis.","volume":"65","author":"Nayak","year":"2017","journal-title":"J Am Geriatr Soc"},{"issue":"12","key":"zoi200889r36","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/S0025-6196(11)61093-8","article-title":"Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis.","volume":"82","author":"Kothawala","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"zoi200889r37","article-title":"Persistence and adherence to parenteral osteoporosis therapies: a systematic review.","author":"Koller","journal-title":"Osteoporosis Int"},{"issue":"3","key":"zoi200889r38","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2105\/AJPH.82.3.395","article-title":"Mortality, disability, and falls in older persons: the role of underlying disease and disability.","volume":"82","author":"Dunn","year":"1992","journal-title":"Am J Public Health"},{"issue":"6","key":"zoi200889r39","doi-asserted-by":"publisher","first-page":"380","DOI":"10.7326\/0003-4819-152-6-201003160-00008","article-title":"Meta-analysis: excess mortality after hip fracture among older women and men.","volume":"152","author":"Haentjens","year":"2010","journal-title":"Ann Intern Med"},{"issue":"7","key":"zoi200889r40","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.2106\/JBJS.G.00675","article-title":"Mortality following the diagnosis of a vertebral compression fracture in the Medicare population.","volume":"90","author":"Lau","year":"2008","journal-title":"J Bone Joint Surg Am"},{"issue":"1602","key":"zoi200889r42","first-page":"105","article-title":"Drugs for postmenopausal osteoporosis.","volume":"62","year":"2020","journal-title":"Med Lett Drugs Ther"},{"issue":"3","key":"zoi200889r43","first-page":"e42","article-title":"Administration costs of denosumab and zoledronic acid for postmenopausal osteoporosis.","volume":"8","author":"Insinga","year":"2016","journal-title":"Am J Pharm Benefits"},{"issue":"4","key":"zoi200889r46","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s001980200033","article-title":"Direct medical costs attributable to osteoporotic fractures.","volume":"13","author":"Gabriel","year":"2002","journal-title":"Osteoporos Int"},{"issue":"4","key":"zoi200889r47","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/jbmr.1789","article-title":"A close examination of healthcare expenditures related to fractures.","volume":"28","author":"Kilgore","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"4","key":"zoi200889r48","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/0272989X06290497","article-title":"Report of nationally representative values for the noninstitutionalized US adult population for 7 health-related quality-of-life scores.","volume":"26","author":"Hanmer","year":"2006","journal-title":"Med Decis Making"},{"key":"zoi200889r49","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1477-7525-12-2","article-title":"Falls and EQ-5D rated quality of life in community-dwelling seniors with concurrent chronic diseases: a cross-sectional study.","volume":"12","author":"Thiem","year":"2014","journal-title":"Health Qual Life Outcomes"},{"issue":"3","key":"zoi200889r50","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00198-017-4317-4","article-title":"Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures\u2014results from the ICUROS.","volume":"29","author":"Svedbom","year":"2018","journal-title":"Osteoporos Int"},{"issue":"1","key":"zoi200889r51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11657-020-0699-6","article-title":"Quality of life after fragility fracture in the Russian Federation: results from the Russian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (ICUROS).","volume":"15","author":"Lesnyak","year":"2020","journal-title":"Arch Osteoporos"},{"issue":"3","key":"zoi200889r52","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025.","volume":"22","author":"Burge","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"1","key":"zoi200889r53","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00198-009-1032-9","article-title":"Updated fracture incidence rates for the US version of FRAX.","volume":"21","author":"Ettinger","year":"2010","journal-title":"Osteoporos Int"},{"issue":"11","key":"zoi200889r54","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1210\/jcem.85.11.6953","article-title":"Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial.","volume":"85","author":"Black","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"zoi200889r57","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11657-020-0706-y","article-title":"Fragility fractures in Europe: burden, management and opportunities.","volume":"15","author":"Borgstr\u00f6m","year":"2020","journal-title":"Arch Osteoporos"},{"issue":"1","key":"zoi200889r58","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1001\/jama.297.1.77","article-title":"Will my patient fall?","volume":"297","author":"Ganz","year":"2007","journal-title":"JAMA"},{"issue":"3","key":"zoi200889r60","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00198-019-05270-6","article-title":"Screening for high hip fracture risk does not impact on falls risk: a post hoc analysis from the SCOOP study.","volume":"31","author":"Condurache","year":"2020","journal-title":"Osteoporos Int"},{"issue":"8","key":"zoi200889r61","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1210\/jc.2018-02614","article-title":"Two-thirds of all fractures are not attributable to osteoporosis and advancing age: implications for fracture prevention.","volume":"104","author":"Mai","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"zoi200889r62","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1093\/ageing\/afg079","article-title":"Falls and bone health services for older people.","volume":"32","author":"Close","year":"2003","journal-title":"Age Ageing"},{"issue":"12","key":"zoi200889r64","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1007\/s00198-009-0942-x","article-title":"Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate.","volume":"20","author":"Kayan","year":"2009","journal-title":"Osteoporos Int"},{"issue":"10","key":"zoi200889r65","doi-asserted-by":"publisher","first-page":"742","DOI":"10.7326\/0003-4819-136-10-200205210-00009","article-title":"Alendronate improves bone mineral density in elderly women with osteoporosis residing in long-term care facilities: a randomized, double-blind, placebo-controlled trial.","volume":"136","author":"Greenspan","year":"2002","journal-title":"Ann Intern Med"},{"issue":"6","key":"zoi200889r66","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1001\/jamainternmed.2015.0747","article-title":"Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: a randomized clinical trial.","volume":"175","author":"Greenspan","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"3","key":"zoi200889r70","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jocd.2011.05.010","article-title":"Official positions for FRAX\u00ae clinical regarding falls and frailty: can falls and frailty be used in FRAX\u00ae? from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX\u00ae.","volume":"14","author":"Masud","year":"2011","journal-title":"J Clin Densitom"},{"key":"zoi200889r28","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780190492939.001.0001","volume-title":"Cost-Effectiveness in Health and Medicine.","author":"Neumann","year":"2016","edition":"2nd ed"},{"key":"zoi200889r10","unstructured":"Guirguis-Blake? JM, Michael? YL, Perdue? LA, Coppola? EL, Beil? TL, Thompson? JH. Interventions to prevent falls in community-dwelling older adults: a systematic review for the US Preventive Services Task Force. Published April 2018. Accessed June 17, 2020. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK525700\/pdf\/Bookshelf_NBK525700.pdf"},{"key":"zoi200889r12","unstructured":"Centers for Disease Control and Prevention. STEADI initiative for health care providers: materials for health care providers. Updated August 12, 2020. Accessed June 17, 2020. https:\/\/www.cdc.gov\/steadi\/materials.html"},{"key":"zoi200889r15","unstructured":"International Society for Clinical Densitometry. 2019 ISCD official positions\u2014adults. Updated January 9, 2020. Accessed June 17, 2020. https:\/\/www.iscd.org\/official-positions\/2019-iscd-official-positions-adult\/"},{"key":"zoi200889r16","unstructured":"US Preventive Services Task Force. Final recommendation statement: osteoporosis to prevent fractures: screening. Published June 26, 2018. Accessed June 17, 2020. https:\/\/uspreventiveservicestaskforce.org\/uspstf\/recommendation\/osteoporosis-screening"},{"key":"zoi200889r17","unstructured":"Medicare.gov. Bone mass measurements. Accessed June 17, 2020. https:\/\/www.medicare.gov\/coverage\/bone-mass-measurements"},{"key":"zoi200889r41","unstructured":"American College of Rheumatology. 2018 Medicare national fee schedule. Accessed June 17, 2020. https:\/\/www.rheumatology.org\/Portals\/0\/Files\/Medicare-National-Fee-Schedule-Table1-2018.pdf"},{"key":"zoi200889r44","unstructured":"Center for Medicare and Medicaid Services. Clinical laboratory fee schedule. Updated September 23, 2020. Accessed June 17, 2020. https:\/\/www.cms.gov\/Medicare\/Medicare-Fee-for-Service-Payment\/ClinicalLabFeeSched\/index.html"},{"key":"zoi200889r45","unstructured":"California Department of Health Care Services. Medi-Cal dental services rate review. Published July 1, 2015. Accessed June 17, 2020. https:\/\/www.dhcs.ca.gov\/services\/Documents\/2015_Dental-Services-Rate-Review.pdf"},{"key":"zoi200889r55","unstructured":"Arias E, Xu J. United States life tables, 2017. Natl Vital Stat Rep. 2019;68(7). Published June 24, 2019. Accessed June 17, 2020. https:\/\/www.cdc.gov\/nchs\/data\/nvsr\/nvsr68\/nvsr68_07-508.pdf"},{"key":"zoi200889r56","unstructured":"US Bureau of Labor Statistics. Consumer Price Index (CPI) databases. Accessed June 17, 2020. https:\/\/www.bls.gov\/cpi\/data.htm"},{"key":"zoi200889r59","unstructured":"Center for Medicare & Medicaid Services. Annual wellness visit. Published August 2018. Accessed June 17, 2020. https:\/\/www.cms.gov\/Outreach-and-Education\/Medicare-Learning-Network-MLN\/MLNProducts\/Downloads\/AWV_Chart_ICN905706.pdf"},{"key":"zoi200889r63","unstructured":"Department of Health. National service framework for older people. Published March 2001. Accessed June 17, 2020. https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/198033\/National_Service_Framework_for_Older_People.pdf"},{"key":"zoi200889r67","unstructured":"University of Sheffield. FRAX\u00ae Fracture Risk Assessment Tool. Accessed June 17, 2020. https:\/\/www.sheffield.ac.uk\/FRAX\/"},{"key":"zoi200889r68","unstructured":"Garvan Institute of Medical Research. Bone fracture risk calculator. Accessed June 17, 2020. https:\/\/www.garvan.org.au\/bone-fracture-risk"},{"key":"zoi200889r69","unstructured":"ClinRisk. Welcome to the QFracture\u00ae-2016 risk calculator. Accessed June 17, 2020. https:\/\/qfracture.org\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2773342\/ito_2020_oi_200889_1606759122.50926.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T12:50:39Z","timestamp":1606827039000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2773342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.27584","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}