{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:07:39Z","timestamp":1788505659172,"version":"build-2803163510"},"reference-count":47,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.36058","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T04:06:47Z","timestamp":1612238807000},"page":"e2036058","source":"Crossref","is-referenced-by-count":14,"title":["Association of Premenopausal Bilateral Oophorectomy With Restless Legs Syndrome"],"prefix":"10.1001","volume":"4","author":[{"given":"Nan","family":"Huo","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin Y.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Gazzuola Rocca","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Rocca","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"},{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Clinic Specialized Research Center of Excellence on Sex Differences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"},{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Clinic Specialized Research Center of Excellence on Sex Differences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"issue":"2","key":"zoi201076r1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S1389-9457(03)00010-8","article-title":"Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.","volume":"4","author":"Allen","year":"2003","journal-title":"Sleep Med"},{"issue":"14","key":"zoi201076r2","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1212\/WNL.0000000000002542","article-title":"Restless legs syndrome associated with major diseases: a systematic review and new concept.","volume":"86","author":"Trenkwalder","year":"2016","journal-title":"Neurology"},{"key":"zoi201076r3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.smrv.2017.10.003","article-title":"Prevalence of restless legs syndrome during pregnancy: a systematic review and meta-analysis.","volume":"40","author":"Chen","year":"2018","journal-title":"Sleep Med Rev"},{"issue":"5","key":"zoi201076r4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/ane.2016.133.issue-5","article-title":"Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment.","volume":"133","author":"Gupta","year":"2016","journal-title":"Acta Neurol Scand"},{"issue":"4","key":"zoi201076r5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.smrv.2011.08.006","article-title":"When gender matters: restless legs syndrome: report of the \u201cRLS and woman\u201d workshop endorsed by the European RLS Study Group.","volume":"16","author":"Manconi","year":"2012","journal-title":"Sleep Med Rev"},{"issue":"5","key":"zoi201076r6","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1097\/AOG.0b013e3181f5ec9d","article-title":"Elective oophorectomy in the United States: trends and in-hospital complications, 1998-2006.","volume":"116","author":"Asante","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"1","key":"zoi201076r7","doi-asserted-by":"publisher","first-page":"34.e1","DOI":"10.1016\/j.ajog.2007.05.039","article-title":"Inpatient hysterectomy surveillance in the United States, 2000-2004.","volume":"198","author":"Whiteman","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"33","key":"zoi201076r8","doi-asserted-by":"publisher","first-page":"9327","DOI":"10.1073\/pnas.1604558113","article-title":"Menopause accelerates biological aging.","volume":"113","author":"Levine","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"zoi201076r9","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types.","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"issue":"3","key":"zoi201076r10","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1212\/01.wnl.0000280573.30975.6a","article-title":"Increased risk of parkinsonism in women who underwent oophorectomy before menopause.","volume":"70","author":"Rocca","year":"2008","journal-title":"Neurology"},{"issue":"1","key":"zoi201076r11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1001\/jamaneurol.2018.3057","article-title":"Association of bilateral salpingo-oophorectomy before menopause onset with medial temporal lobe neurodegeneration.","volume":"76","author":"Zeydan","year":"2019","journal-title":"JAMA Neurol"},{"issue":"1-4","key":"zoi201076r12","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1159\/000334764","article-title":"Hysterectomy, oophorectomy, estrogen, and the risk of dementia.","volume":"10","author":"Rocca","year":"2012","journal-title":"Neurodegener Dis"},{"issue":"11","key":"zoi201076r13","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1212\/01.wnl.0000276984.19542.e6","article-title":"Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause.","volume":"69","author":"Rocca","year":"2007","journal-title":"Neurology"},{"issue":"11","key":"zoi201076r15","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/j.mayocp.2016.08.002","article-title":"Accelerated accumulation of multimorbidity after bilateral oophorectomy: a population-based cohort study.","volume":"91","author":"Rocca","year":"2016","journal-title":"Mayo Clin Proc"},{"issue":"9","key":"zoi201076r16","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1093\/gerona\/glx026","article-title":"Bilateral oophorectomy and accelerated aging: cause or effect?","volume":"72","author":"Rocca","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"11","key":"zoi201076r17","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-018861","article-title":"Cohort profile: the Mayo Clinic Cohort Study of Oophorectomy and Aging-2 (MOA-2) in Olmsted County, Minnesota (USA).","volume":"7","author":"Rocca","year":"2017","journal-title":"BMJ Open"},{"issue":"9","key":"zoi201076r19","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1093\/aje\/kwq482","article-title":"Use of a medical records linkage system to enumerate a dynamic population over time: the Rochester Epidemiology Project.","volume":"173","author":"St Sauver","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"2","key":"zoi201076r20","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.mayocp.2011.11.009","article-title":"Generalizability of epidemiological findings and public health decisions: an illustration from the Rochester Epidemiology Project.","volume":"87","author":"St Sauver","year":"2012","journal-title":"Mayo Clin Proc"},{"issue":"12","key":"zoi201076r21","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.mayocp.2012.08.012","article-title":"History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population.","volume":"87","author":"Rocca","year":"2012","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"zoi201076r22","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1093\/ije\/dys195","article-title":"Data resource profile: the Rochester Epidemiology Project (REP) medical records\u2013linkage system.","volume":"41","author":"St Sauver","year":"2012","journal-title":"Int J Epidemiol"},{"key":"zoi201076r25","doi-asserted-by":"crossref","DOI":"10.5888\/pcd10.120239","article-title":"Defining and measuring chronic conditions: imperatives for research, policy, program, and practice.","volume":"10","author":"Goodman","year":"2013","journal-title":"Prev Chronic Dis"},{"issue":"1-2","key":"zoi201076r27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mce.2014.01.020","article-title":"Oophorectomy, estrogen, and dementia: a 2014 update.","volume":"389","author":"Rocca","year":"2014","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"zoi201076r28","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","article-title":"Restless legs syndrome prevalence and impact: REST general population study.","volume":"165","author":"Allen","year":"2005","journal-title":"Arch Intern Med"},{"issue":"2","key":"zoi201076r29","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1001\/archinte.164.2.196","article-title":"Sex and the risk of restless legs syndrome in the general population.","volume":"164","author":"Berger","year":"2004","journal-title":"Arch Intern Med"},{"issue":"1","key":"zoi201076r30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000050750","article-title":"Restless legs syndrome among working-aged women.","volume":"46","author":"Ulfberg","year":"2001","journal-title":"Eur Neurol"},{"issue":"6","key":"zoi201076r31","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1002\/mds.v16:6","article-title":"Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms.","volume":"16","author":"Ulfberg","year":"2001","journal-title":"Mov Disord"},{"issue":"1","key":"zoi201076r32","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S0022-3999(02)00443-9","article-title":"Prevalence of restless legs syndrome and periodic limb movement disorder in the general population.","volume":"53","author":"Ohayon","year":"2002","journal-title":"J Psychosom Res"},{"issue":"4","key":"zoi201076r33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.smrv.2011.05.002","article-title":"Epidemiology of restless legs syndrome: a synthesis of the literature.","volume":"16","author":"Ohayon","year":"2012","journal-title":"Sleep Med Rev"},{"issue":"7","key":"zoi201076r34","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1001\/jamainternmed.2013.3733","article-title":"Pharmacologic therapy for primary restless legs syndrome: a systematic review and meta-analysis.","volume":"173","author":"Wilt","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"7","key":"zoi201076r35","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1001\/jama.2016.21375","article-title":"Restless legs syndrome.","volume":"317","author":"Muth","year":"2017","journal-title":"JAMA"},{"issue":"23","key":"zoi201076r36","doi-asserted-by":"publisher","first-page":"8604","DOI":"10.1523\/JNEUROSCI.20-23-08604.2000","article-title":"Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson\u2019s disease and memory.","volume":"20","author":"Leranth","year":"2000","journal-title":"J Neurosci"},{"issue":"4","key":"zoi201076r37","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.mcn.2004.04.012","article-title":"Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice.","volume":"27","author":"Hill","year":"2004","journal-title":"Mol Cell Neurosci"},{"issue":"6","key":"zoi201076r38","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0028-3908(01)00009-0","article-title":"Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture.","volume":"40","author":"Ibi","year":"2001","journal-title":"Neuropharmacology"},{"issue":"3","key":"zoi201076r39","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF02555109","article-title":"The effect of endogenous estrogen fluctuation on metabolism of 25-hydroxyvitamin D.","volume":"39","author":"Buchanan","year":"1986","journal-title":"Calcif Tissue Int"},{"issue":"22","key":"zoi201076r40","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1212\/WNL.0000000000000470","article-title":"Multimorbidity and the risk of restless legs syndrome in 2 prospective cohort studies.","volume":"82","author":"Szentkir\u00e1lyi","year":"2014","journal-title":"Neurology"},{"issue":"7","key":"zoi201076r41","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1177\/1060028018760296","article-title":"Drug-induced restless legs syndrome.","volume":"52","author":"Patatanian","year":"2018","journal-title":"Ann Pharmacother"},{"issue":"5","key":"zoi201076r42","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.pnpbp.2007.03.011","article-title":"Characteristics and clinical correlates of restless legs syndrome in schizophrenia.","volume":"31","author":"Kang","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2-3","key":"zoi201076r43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ejphar.2005.02.005","article-title":"Estrogen mediated inhibition of dopamine transport in the striatum: regulation by G alpha i\/o.","volume":"511","author":"Thompson","year":"2005","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"zoi201076r44","doi-asserted-by":"publisher","first-page":"119","DOI":"10.5664\/jcsm.1756","article-title":"Incidence of restless legs syndrome and its correlates.","volume":"8","author":"Budhiraja","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"zoi201076r45","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.smrv.2017.03.003","article-title":"Gender differences in obstructive sleep apnoea, insomnia and restless legs syndrome in adults \u2014 what do we know: a clinical update.","volume":"38","author":"Theorell-Hagl\u00f6w","year":"2018","journal-title":"Sleep Med Rev"},{"issue":"6","key":"zoi201076r46","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1055\/s-0037-1608845","article-title":"Movement disorders in women.","volume":"37","author":"Baker","year":"2017","journal-title":"Semin Neurol"},{"issue":"12","key":"zoi201076r47","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1007\/s00415-007-0624-6","article-title":"Prevalence of the restless legs syndrome in transsexual patients: the hormonal hypothesis revisited.","volume":"254","author":"Fulda","year":"2007","journal-title":"J Neurol"},{"key":"zoi201076r14","year":"2006"},{"key":"zoi201076r18","volume-title":"International Classification of Diseases, Ninth Revision (ICD-9).","author":"World Health Organization","year":"1977"},{"key":"zoi201076r23","volume-title":"International Classification of Diseases, Eighth Revision (ICD-8).","author":"World Health Organization","year":"1965"},{"key":"zoi201076r24","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders.","author":"American Psychiatric Association","year":"2013","edition":"5th ed"},{"key":"zoi201076r26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4757-3294-8_3","volume-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2000"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2775661\/huo_2021_oi_201076_1615225609.194.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T16:01:33Z","timestamp":1615392093000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2775661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.36058","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}