{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:26:00Z","timestamp":1790879160269,"version":"4.1.0"},"reference-count":31,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.5202","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T15:02:19Z","timestamp":1590073339000},"page":"e205202","source":"Crossref","is-referenced-by-count":123,"title":["Participation of Women and Older Participants in Randomized Clinical Trials of Lipid-Lowering Therapies"],"prefix":"10.1001","volume":"3","author":[{"given":"Safi U.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Medicine, West Virginia University, Morgantown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Zia","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, West Virginia University, Morgantown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charumathi","family":"Raghu Subramanian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington Hospital Health Care System, Fremont, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haris","family":"Riaz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, West Virginia University, Morgantown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Naeem","family":"Lone","sequence":"additional","affiliation":[{"name":"Department of Medicine, West Virginia University, Morgantown"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, John H. Stroger Cook County Hospital, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve-Marie","family":"Benson","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine, Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Blaha","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine, Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine, Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Gulati","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Arizona College of Medicine, Phoenix"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Michos","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine, Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"issue":"10100","key":"zoi200250r1","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","article-title":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016.","volume":"390","author":"GBD 2016 Causes of Death Collaborators","year":"2017","journal-title":"Lancet"},{"issue":"17","key":"zoi200250r2","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.jacc.2009.04.098","article-title":"Women and ischemic heart disease: evolving knowledge.","volume":"54","author":"Shaw","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"zoi200250r3","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.cger.2009.07.007","article-title":"The burden of cardiovascular disease in the elderly: morbidity, mortality, and costs.","volume":"25","author":"Yazdanyar","year":"2009","journal-title":"Clin Geriatr Med"},{"issue":"4","key":"zoi200250r4","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1161\/CIRCOUTCOMES.112.967638","article-title":"Most important articles on cardiovascular disease among racial and ethnic minorities.","volume":"5","author":"Mody","year":"2012","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"18","key":"zoi200250r5","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1016\/j.jacc.2018.02.070","article-title":"Participation of women in clinical trials supporting FDA approval of cardiovascular drugs.","volume":"71","author":"Scott","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"zoi200250r6","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1001\/jamacardio.2018.2559","article-title":"Enrollment of older patients, women, and racial and ethnic minorities in contemporary heart failure clinical trials: a systematic review.","volume":"3","author":"Tahhan","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"1","key":"zoi200250r7","doi-asserted-by":"publisher","first-page":"708","DOI":"10.18549\/PharmPract.2016.01.708","article-title":"Women\u2019s involvement in clinical trials: historical perspective and future implications.","volume":"14","author":"Liu","year":"2016","journal-title":"Pharm Pract (Granada)"},{"issue":"139","key":"zoi200250r8","first-page":"39406","article-title":"Guideline for the study and evaluation of gender differences in the clinical evaluation of drugs; notice.","volume":"58","author":"US Food and Drug Administration","year":"1993","journal-title":"Fed Regist"},{"issue":"2","key":"zoi200250r9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1161\/CIRCOUTCOMES.110.868307","article-title":"Representation of women in randomized clinical trials of cardiovascular disease prevention.","volume":"3","author":"Melloni","year":"2010","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"8","key":"zoi200250r10","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1177\/2047487318766612","article-title":"A Bayesian network meta-analysis of PCSK9 inhibitors, statins and ezetimibe with or without statins for cardiovascular outcomes.","volume":"25","author":"Khan","year":"2018","journal-title":"Eur J Prev Cardiol"},{"issue":"5","key":"zoi200250r11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1177\/2047487318816495","article-title":"Effects of high-density lipoprotein targeting treatments on cardiovascular outcomes: A systematic review and meta-analysis.","volume":"26","author":"Riaz","year":"2019","journal-title":"Eur J Prev Cardiol"},{"issue":"24","key":"zoi200250r12","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.1016\/j.jacc.2018.11.002","article-title":"AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"73","author":"Grundy","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"zoi200250r13","first-page":"e563","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"},{"key":"zoi200250r14","doi-asserted-by":"publisher","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-analyses: the PRISMA statement.","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"issue":"12","key":"zoi200250r15","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1001\/jama.2016.13985","article-title":"Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis.","volume":"316","author":"Silverman","year":"2016","journal-title":"JAMA"},{"issue":"15","key":"zoi200250r16","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1001\/jama.2018.2525","article-title":"Association between baseline LDL-C level and total and cardiovascular mortality after LDL-C lowering: a systematic review and meta-analysis.","volume":"319","author":"Navarese","year":"2018","journal-title":"JAMA"},{"issue":"18","key":"zoi200250r17","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1001\/jama.2016.16405","article-title":"Reporting sex, gender, or both in clinical research?","volume":"316","author":"Clayton","year":"2016","journal-title":"JAMA"},{"key":"zoi200250r18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41073-016-0006-7","article-title":"Conflict of interest disclosure in biomedical research: a review of current practices, biases, and the role of public registries in improving transparency.","volume":"1","author":"Dunn","year":"2016","journal-title":"Res Integr Peer Rev"},{"issue":"3","key":"zoi200250r19","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1001\/jamacardio.2016.0218","article-title":"Drugs for primary prevention of atherosclerotic cardiovascular disease: an overview of systematic reviews.","volume":"1","author":"Karmali","year":"2016","journal-title":"JAMA Cardiol"},{"issue":"7","key":"zoi200250r20","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1089\/jwh.2012.3753","article-title":"Participation of women and sex analyses in late-phase clinical trials of new molecular entity drugs and biologics approved by the FDA in 2007-2009.","volume":"22","author":"Poon","year":"2013","journal-title":"J Womens Health (Lrchmt)"},{"issue":"6","key":"zoi200250r21","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/MJT.0000000000000177","article-title":"Demographics of clinical trials participants in pivotal clinical trials for new molecular entity drugs and biologics approved by FDA From 2010 to 2012.","volume":"22","author":"Eshera","year":"2015","journal-title":"Am J Ther"},{"issue":"12","key":"zoi200250r22","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.2337\/dc12-1801","article-title":"Diabetes in older adults.","volume":"35","author":"Kirkman","year":"2012","journal-title":"Diabetes Care"},{"issue":"3","key":"zoi200250r23","first-page":"154","article-title":"Cholesterol and cardiovascular disease in the elderly: facts and gaps.","volume":"4","author":"F\u00e9lix-Redondo","year":"2013","journal-title":"Aging Dis"},{"issue":"24","key":"zoi200250r24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010498","article-title":"Gender differences in patient-reported outcomes among adults with atherosclerotic cardiovascular disease.","volume":"7","author":"Okunrintemi","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"zoi200250r25","first-page":"88","article-title":"Social factors affecting interest in participating in a prostate cancer chemoprevention trial.","volume":"14","author":"Lee","year":"1999","journal-title":"J Cancer Educ"},{"issue":"5","key":"zoi200250r26","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/hsc.2004.12.issue-5","article-title":"Why ethnic minority groups are under-represented in clinical trials: a review of the literature.","volume":"12","author":"Hussain-Gambles","year":"2004","journal-title":"Health Soc Care Community"},{"issue":"6","key":"zoi200250r27","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1001\/archinternmed.2011.31","article-title":"The persistent exclusion of older patients from ongoing clinical trials regarding heart failure.","volume":"171","author":"Cherubini","year":"2011","journal-title":"Arch Intern Med"},{"issue":"4","key":"zoi200250r28","doi-asserted-by":"publisher","first-page":"184","DOI":"10.4103\/2229-3485.167099","article-title":"Elderly patients\u2019 participation in clinical trials.","volume":"6","author":"Shenoy","year":"2015","journal-title":"Perspect Clin Res"},{"issue":"5","key":"zoi200250r29","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1001\/jamainternmed.2016.9650","article-title":"Association of a community campaign for better beverage choices with beverage purchases from supermarkets.","volume":"177","author":"Schwartz","year":"2017","journal-title":"JAMA Intern Med"},{"issue":"6","key":"zoi200250r30","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/CIRCGENETICS.112.962787","article-title":"Impact of ancestry and common genetic variants on QT interval in African Americans.","volume":"5","author":"Smith","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"issue":"3","key":"zoi200250r31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1177\/1740774516631735","article-title":"Recruitment strategies and challenges in a large intervention trial: Systolic Blood Pressure Intervention Trial.","volume":"13","author":"Ramsey","year":"2016","journal-title":"Clin Trials"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2766226\/khan_2020_oi_200250.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T15:02:39Z","timestamp":1590073359000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2766226"}},"subtitle":["A Systematic Review"],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.5202","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,21]]}}}