{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:49:30Z","timestamp":1789516170815,"version":"build-2803163510"},"reference-count":53,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2020.8256","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T15:01:44Z","timestamp":1596034904000},"page":"e208256","source":"Crossref","is-referenced-by-count":66,"title":["Association of Maternal Opioid Use in Pregnancy With Adverse Perinatal Outcomes in Ontario, Canada, From 2012 to 2018"],"prefix":"10.1001","volume":"3","author":[{"given":"Daniel J.","family":"Corsi","sequence":"first","affiliation":[{"name":"OMNI Research Group, Clinical Epidemiology Program, Centre for Practice Changing Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Children\u2019s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshayne B.","family":"Fell","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Children\u2019s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Wu","family":"Wen","sequence":"additional","affiliation":[{"name":"OMNI Research Group, Clinical Epidemiology Program, Centre for Practice Changing Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Walker","sequence":"additional","affiliation":[{"name":"OMNI Research Group, Clinical Epidemiology Program, Centre for Practice Changing Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"zoi200353r4","author":"Salihu","year":"2018","journal-title":"Am J Med"},{"issue":"1","key":"zoi200353r5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/GRF.0b013e31827feeb9","article-title":"Overview and epidemiology of substance abuse in pregnancy.","volume":"56","author":"Wendell","year":"2013","journal-title":"Clin Obstet Gynecol"},{"issue":"5","key":"zoi200353r6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1001\/archinternmed.2011.1741","article-title":"Sex differences in long-term opioid use: cautionary notes for prescribing in women.","volume":"172","author":"Darnall","year":"2012","journal-title":"Arch Intern Med"},{"issue":"3","key":"zoi200353r8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jogc.2016.11.009","article-title":"Infants born to opioid-dependent women in Ontario, 2002-2014.","volume":"39","author":"Brogly","year":"2017","journal-title":"J Obstet Gynaecol Can"},{"issue":"2","key":"zoi200353r9","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1542\/peds.2011-3212","article-title":"Neonatal drug withdrawal.","volume":"129","author":"Hudak","year":"2012","journal-title":"Pediatrics"},{"issue":"2","key":"zoi200353r10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/157015908784533842","article-title":"The effects of maternally administered methadone, buprenorphine and naltrexone on offspring: review of human and animal data.","volume":"6","author":"Farid","year":"2008","journal-title":"Curr Neuropharmacol"},{"issue":"1","key":"zoi200353r11","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.9778\/cmajo.20140065","article-title":"Neonatal opioid withdrawal and antenatal opioid prescribing.","volume":"3","author":"Turner","year":"2015","journal-title":"CMAJ Open"},{"issue":"8","key":"zoi200353r12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/jp.2015.63","article-title":"Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012.","volume":"35","author":"Patrick","year":"2015","journal-title":"J Perinatol"},{"issue":"18","key":"zoi200353r13","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.2012.3951","article-title":"Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.","volume":"307","author":"Patrick","year":"2012","journal-title":"JAMA"},{"issue":"3","key":"zoi200353r14","first-page":"e488","article-title":"Neonatal abstinence syndrome clinical practice guidelines for Ontario.","volume":"19","author":"Dow","year":"2012","journal-title":"J Popul Ther Clin Pharmacol"},{"issue":"3","key":"zoi200353r15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/02791072.1975.10471519","article-title":"Narcotics dependence in pregnancy.","volume":"7","author":"Finnegan","year":"1975","journal-title":"J Psychedelic Drugs"},{"issue":"11","key":"zoi200353r16","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1111\/j.1360-0443.1997.tb02877.x","article-title":"The relationship between maternal use of heroin and methadone and infant birth weight.","volume":"92","author":"Hulse","year":"1997","journal-title":"Addiction"},{"issue":"5","key":"zoi200353r17","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1542\/peds.2014-3299","article-title":"Prescription opioid epidemic and infant outcomes.","volume":"135","author":"Patrick","year":"2015","journal-title":"Pediatrics"},{"issue":"3","key":"zoi200353r18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s10995-014-1536-6","article-title":"Clinical correlates of prescription opioid analgesic use in pregnancy.","volume":"19","author":"Smith","year":"2015","journal-title":"Matern Child Health J"},{"key":"zoi200353r19","first-page":"5","article-title":"Birth and neonatal outcomes following opioid use in pregnancy: a Danish population-based study.","volume":"9","author":"N\u00f8rgaard","year":"2015","journal-title":"Subst Abuse"},{"key":"zoi200353r20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.reprotox.2016.04.021","article-title":"Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications.","volume":"62","author":"Leemaqz","year":"2016","journal-title":"Reprod Toxicol"},{"key":"zoi200353r21","first-page":"89","article-title":"A Swedish population-based study of adverse birth outcomes among pregnant women treated with buprenorphine or methadone: preliminary findings.","volume":"10","author":"Wurst","year":"2016","journal-title":"Subst Abuse"},{"key":"zoi200353r22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2431-14-93","article-title":"The economic burden of prematurity in Canada.","volume":"14","author":"Johnston","year":"2014","journal-title":"BMC Pediatr"},{"issue":"1","key":"zoi200353r23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/AOG.0000000000002054","article-title":"Opioid use in pregnancy, neonatal abstinence syndrome, and childhood outcomes: executive summary of a joint workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation.","volume":"130","author":"Reddy","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"10","key":"zoi200353r24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ogrm.2017.07.003","article-title":"Substance misuse in pregnancy.","volume":"27","author":"Cohen","year":"2017","journal-title":"Obstet Gynaecol Reprod Med"},{"issue":"24","key":"zoi200353r26","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1056\/NEJMoa1005359","article-title":"Neonatal abstinence syndrome after methadone or buprenorphine exposure.","volume":"363","author":"Jones","year":"2010","journal-title":"N Engl J Med"},{"issue":"1","key":"zoi200353r27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.drugalcdep.2013.06.004","article-title":"Time to initiation of treatment for neonatal abstinence syndrome in neonates exposed in utero to buprenorphine or methadone.","volume":"133","author":"Gaalema","year":"2013","journal-title":"Drug Alcohol Depend"},{"key":"zoi200353r28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1360-0443.2012.04039.x","article-title":"Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates.","volume":"107","author":"Gaalema","year":"2012","journal-title":"Addiction"},{"issue":"11","key":"zoi200353r29","first-page":"e441","article-title":"Narcotic-exposed neonates in a First Nations population in northwestern Ontario: incidence and implications.","volume":"57","author":"Kelly","year":"2011","journal-title":"Can Fam Physician"},{"issue":"10","key":"zoi200353r30","first-page":"e493","article-title":"Incidence of narcotic abuse during pregnancy in northwestern Ontario: three-year prospective cohort study.","volume":"60","author":"Kelly","year":"2014","journal-title":"Can Fam Physician"},{"issue":"1","key":"zoi200353r31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.24095\/hpcdp.32.1.05","article-title":"2008 Niday Perinatal Database quality audit: report of a quality assurance project.","volume":"32","author":"Dunn","year":"2011","journal-title":"Chronic Dis Inj Can"},{"issue":"1","key":"zoi200353r32","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1186\/s12913-019-4825-3","article-title":"Data accuracy in the Ontario birth registry: a chart re-abstraction study.","volume":"19","author":"Dunn","year":"2019","journal-title":"BMC Health Serv Res"},{"issue":"9","key":"zoi200353r34","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S1701-2163(16)34656-4","article-title":"Temporal trends and regional variations in severe maternal morbidity in Canada, 2003 to 2007.","volume":"32","author":"Liu","year":"2010","journal-title":"J Obstet Gynaecol Can"},{"issue":"8","key":"zoi200353r35","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/MLR.0b013e318178eae4","article-title":"Measuring maternal morbidity in routinely collected health data: development and validation of a maternal morbidity outcome indicator.","volume":"46","author":"Roberts","year":"2008","journal-title":"Med Care"},{"issue":"3","key":"zoi200353r38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/00031305.1986.10475403","article-title":"Standard distance in univariate and multivariate analysis.","volume":"40","author":"Flury","year":"1986","journal-title":"Am Stat"},{"issue":"25","key":"zoi200353r39","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1002\/sim.3697","article-title":"Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.","volume":"28","author":"Austin","year":"2009","journal-title":"Stat Med"},{"issue":"3","key":"zoi200353r40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/pan\/mpl013","article-title":"Matching as nonparametric preprocessing for reducing model dependence in parametric causal inference.","volume":"15","author":"Ho","year":"2007","journal-title":"Polit Anal"},{"issue":"10","key":"zoi200353r41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v011.i10","article-title":"Econometric computing with HC and HAC covariance matrix estimators.","volume":"11","author":"Zeileis","year":"2004","journal-title":"J Stat Softw"},{"issue":"3","key":"zoi200353r42","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0304-4076(85)90158-7","article-title":"Some heteroskedasticity-consistent covariance matrix estimators with improved finite sample properties.","volume":"29","author":"MacKinnon","year":"1985","journal-title":"J Econom"},{"issue":"1","key":"zoi200353r43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2288-3-21","article-title":"Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.","volume":"3","author":"Barros","year":"2003","journal-title":"BMC Med Res Methodol"},{"issue":"8","key":"zoi200353r44","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1503\/cmaj.101715","article-title":"Overestimation of risk ratios by odds ratios in trials and cohort studies: alternatives to logistic regression.","volume":"184","author":"Knol","year":"2012","journal-title":"CMAJ"},{"issue":"3","key":"zoi200353r45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.siny.2012.01.007","article-title":"Epidemiology of late and moderate preterm birth.","volume":"17","author":"Shapiro-Mendoza","year":"2012","journal-title":"Semin Fetal Neonatal Med"},{"issue":"10","key":"zoi200353r47","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jogc.2017.07.017","article-title":"Screening and management of substance use in pregnancy: a review.","volume":"39","author":"Cook","year":"2017","journal-title":"J Obstet Gynaecol Can"},{"issue":"2","key":"zoi200353r48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1360-0443.2012.04049.x","article-title":"Prescription drug use among pregnant women in opioid maintenance treatment.","volume":"108","author":"Lund","year":"2013","journal-title":"Addiction"},{"key":"zoi200353r49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s13669-016-0168-9","article-title":"Caring for pregnant women with opioid use disorder in the USA: expanding and improving treatment.","volume":"5","author":"Saia","year":"2016","journal-title":"Curr Obstet Gynecol Rep"},{"issue":"1","key":"zoi200353r50","article-title":"Victimized or validated? responses to substance-using pregnant women.","volume":"24","author":"Greaves","year":"2004","journal-title":"Can Womens Stud"},{"issue":"1","key":"zoi200353r51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40352-015-0015-5","article-title":"Pregnant women and substance use: fear, stigma, and barriers to care.","volume":"3","author":"Stone","year":"2015","journal-title":"Health Justice"},{"issue":"5","key":"zoi200353r52","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/14659891003721133","article-title":"Self-report of illicit substance use versus urine toxicology results from at-risk pregnant women.","volume":"16","author":"Yonkers","year":"2011","journal-title":"J Subst Use"},{"key":"zoi200353r1","volume-title":"Opioid-Related Harms in Canada","author":"Canadian Institute for Health Information","year":"2017"},{"key":"zoi200353r25","volume-title":"Buprenorphine","author":"Kumar","year":"2020"},{"key":"zoi200353r33","volume-title":"Perinatal Health Indicators for Canada 2013: A Report of the Canadian Perinatal Surveillance System","author":"Public Health Agency of Canada","year":"2013"},{"key":"zoi200353r37","volume-title":"Postal Code Conversion File Plus (PCCF+), Version 6D","author":"Statistics Canada","year":"2016"},{"key":"zoi200353r46","volume-title":"Conception to Birth: Epidemiology of Prenatal Development","author":"Kline","year":"1989"},{"key":"zoi200353r2","unstructured":"Special Advisory Committee on the Epidemic of Opioid Overdoses. National Report: Apparent Opioid-Related Deaths in Canada. Public Health Agency of Canada. Published March 2018. Updated March 17, 2020. Accessed March 19, 2020. https:\/\/www.canada.ca\/en\/public-health\/services\/publications\/healthy-living\/national-report-apparent-opioid-related-deaths-released-march-2018.html"},{"key":"zoi200353r3","unstructured":"Mattson? CL, Schieber? L, Scholl? L, . National Center for Injury Prevention and Control, Centers for Disease Control and Prevention. Annual surveillance report of drug-related risks and outcomes: United States, 2017. Published August 31, 2017. Accessed June 25, 2020. https:\/\/www.cdc.gov\/drugoverdose\/pdf\/pubs\/2017-cdc-drug-surveillance-report.pdf"},{"key":"zoi200353r7","unstructured":"Health Canada. Canadian Tobacco Alcohol and Drugs (CTADS): 2015. Corrected March 2017. Accessed June 25, 2020. https:\/\/www.canada.ca\/en\/health-canada\/services\/canadian-tobacco-alcohol-drugs-survey\/2015-summary.html"},{"key":"zoi200353r36","unstructured":"Statistics Canada. Census dictionary: census year, 2011. Catalogue No. 98-301-X, 2012. Accessed June 25, 2020. https:\/\/www12.statcan.gc.ca\/census-recensement\/2011\/ref\/dict\/98-301-X2011001-eng.pdf"},{"key":"zoi200353r53","unstructured":"Government of Canada. Canadian Tobacco, Alcohol and Drugs Survey (CTADS): summary of results for 2017. Updated January 4, 2019. Accessed June 25, 2020. https:\/\/www.canada.ca\/en\/health-canada\/services\/canadian-tobacco-alcohol-drugs-survey\/2017-summary.html"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2768766\/corsi_2020_oi_200353_1597680382.67093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:17:18Z","timestamp":1723335438000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2768766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,29]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.8256","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,29]]}}}