{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:36:06Z","timestamp":1791513366187,"version":"4.3.4"},"reference-count":49,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2021.11806","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T15:14:52Z","timestamp":1623251692000},"page":"e2111806","source":"Crossref","is-referenced-by-count":40,"title":["Estimated Cardiorespiratory Hospitalizations Attributable to Influenza and Respiratory Syncytial Virus Among Long-term Care Facility Residents"],"prefix":"10.1001","volume":"4","author":[{"given":"Elliott","family":"Bosco","sequence":"first","affiliation":[{"name":"Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center for Gerontology and Healthcare Research, School of Public Health, Brown University School of Public Health, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robertus","family":"van Aalst","sequence":"additional","affiliation":[{"name":"Modeling, Epidemiology, and Data Science, Sanofi Pasteur, Swiftwater, Pennsylvania"},{"name":"Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"McConeghy","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center of Innovation in Long-term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center for Gerontology and Healthcare Research, School of Public Health, Brown University School of Public Health, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patience","family":"Moyo","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center for Gerontology and Healthcare Research, School of Public Health, Brown University School of Public Health, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa N.","family":"Eliot","sequence":"additional","affiliation":[{"name":"Center for Gerontology and Healthcare Research, School of Public Health, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Chit","sequence":"additional","affiliation":[{"name":"Modeling, Epidemiology, and Data Science, Sanofi Pasteur, Swiftwater, Pennsylvania"},{"name":"Leslie Dan School of Pharmacy, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gravenstein","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center for Gerontology and Healthcare Research, School of Public Health, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center of Innovation in Long-term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island"},{"name":"Department of Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Zullo","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center for Gerontology and Healthcare Research, School of Public Health, Brown University School of Public Health, Providence, Rhode Island"},{"name":"Center of Innovation in Long-term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island"},{"name":"Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"issue":"2","key":"zoi210349r1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1001\/jama.289.2.179","article-title":"Mortality associated with influenza and respiratory syncytial virus in the United States.","volume":"289","author":"Thompson","year":"2003","journal-title":"JAMA"},{"issue":"11","key":"zoi210349r2","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1377\/hlthaff.2016.0462","article-title":"Modeling the economic burden of adult vaccine-preventable diseases in the United States.","volume":"35","author":"Ozawa","year":"2016","journal-title":"Health Aff (Millwood)"},{"issue":"17","key":"zoi210349r4","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1056\/NEJMoa043951","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults.","volume":"352","author":"Falsey","year":"2005","journal-title":"N Engl J Med"},{"issue":"3","key":"zoi210349r5","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1001\/jamacardio.2016.0433","article-title":"Seasonal influenza infections and cardiovascular disease mortality.","volume":"1","author":"Nguyen","year":"2016","journal-title":"JAMA Cardiol"},{"issue":"5","key":"zoi210349r6","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/irv.2017.11.issue-5","article-title":"The hidden burden of influenza: a review of the extra-pulmonary complications of influenza infection.","volume":"11","author":"Sellers","year":"2017","journal-title":"Influenza Other Respir Viruses"},{"issue":"6","key":"zoi210349r7","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1046\/j.1365-2389.2003.51254.x","article-title":"Influenza- and respiratory syncytial virus-associated morbidity and mortality in the nursing home population.","volume":"51","author":"Ellis","year":"2003","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"zoi210349r8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/irv.v14.2","article-title":"State-level estimates of excess hospitalizations and deaths associated with influenza.","volume":"14","author":"Czaja","year":"2020","journal-title":"Influenza Other Respir Viruses"},{"issue":"5","key":"zoi210349r9","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.vaccine.2006.09.041","article-title":"Influenza- and RSV-associated hospitalizations among adults.","volume":"25","author":"Mullooly","year":"2007","journal-title":"Vaccine"},{"issue":"5","key":"zoi210349r10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/irv.2014.8.issue-5","article-title":"Estimates of mortality attributable to influenza and RSV in the United States during 1997-2009 by influenza type or subtype, age, cause of death, and risk status.","volume":"8","author":"Matias","year":"2014","journal-title":"Influenza Other Respir Viruses"},{"issue":"1","key":"zoi210349r11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12889-017-4177-z","article-title":"Estimates of hospitalization attributable to influenza and RSV in the US during 1997-2009, by age and risk status.","volume":"17","author":"Matias","year":"2017","journal-title":"BMC Public Health"},{"key":"zoi210349r12","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1186\/s12889-016-3128-4","article-title":"Modelling estimates of age-specific influenza-related hospitalisation and mortality in the United Kingdom.","volume":"16","author":"Matias","year":"2016","journal-title":"BMC Public Health"},{"issue":"1","key":"zoi210349r13","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1186\/s12879-015-1218-z","article-title":"Modelling estimates of the burden of respiratory syncytial virus infection in adults and the elderly in the United Kingdom.","volume":"15","author":"Fleming","year":"2015","journal-title":"BMC Infect Dis"},{"issue":"12","key":"zoi210349r14","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1093\/infdis\/jit839","article-title":"Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness.","volume":"209","author":"Falsey","year":"2014","journal-title":"J Infect Dis"},{"issue":"3","key":"zoi210349r15","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.idc.2007.07.005","article-title":"Infections in residents of nursing homes.","volume":"21","author":"Mathe\u00ef","year":"2007","journal-title":"Infect Dis Clin North Am"},{"issue":"10","key":"zoi210349r16","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1086\/501971","article-title":"Influenza outbreaks in long-term-care facilities: how can we do better?","volume":"23","author":"Simor","year":"2002","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"3","key":"zoi210349r17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2147\/ciia.2006.1.issue-3","article-title":"Effect of aging on respiratory system physiology and immunology.","volume":"1","author":"Sharma","year":"2006","journal-title":"Clin Interv Aging"},{"key":"zoi210349r18","first-page":"1489","article-title":"The aging lung.","volume":"8","author":"Lowery","year":"2013","journal-title":"Clin Interv Aging"},{"issue":"3","key":"zoi210349r19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030503","article-title":"The impacts of cellular senescence in elderly pneumonia and in age-related lung diseases that increase the risk of respiratory infections.","volume":"18","author":"Yanagi","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"zoi210349r20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12877-020-1457-8","article-title":"Risk factors for pneumonia and influenza hospitalizations in long-term care facility residents: a retrospective cohort study.","volume":"20","author":"Moyo","year":"2020","journal-title":"BMC Geriatr"},{"issue":"3","key":"zoi210349r21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1086\/502030","article-title":"Pneumonia in the long-term-care facility.","volume":"23","author":"Marrie","year":"2002","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"6","key":"zoi210349r22","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/oxfordjournals.aje.a116348","article-title":"Intensive surveillance for infections in a three-year study of nursing home patients.","volume":"135","author":"Jackson","year":"1992","journal-title":"Am J Epidemiol"},{"issue":"6","key":"zoi210349r23","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofz230","article-title":"Long-term care facility variation in the incidence of pneumonia and influenza.","volume":"6","author":"Bosco","year":"2019","journal-title":"Open Forum Infect Dis"},{"issue":"7","key":"zoi210349r24","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1111\/jgs.2012.60.issue-7","article-title":"Effect of influenza on functional decline.","volume":"60","author":"Gozalo","year":"2012","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"zoi210349r25","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1111\/jgs.13617","article-title":"Estimating the effect of influenza vaccination on nursing home residents\u2019 morbidity and mortality.","volume":"63","author":"Pop-Vicas","year":"2015","journal-title":"J Am Geriatr Soc"},{"issue":"8","key":"zoi210349r26","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1093\/cid\/ciaa081","article-title":"Geographic variation in pneumonia and influenza in long-term care facilities: a national study.","volume":"71","author":"Bosco","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"4","key":"zoi210349r27","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.ypmed.2007.08.012","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"45","author":"von Elm","year":"2007","journal-title":"Prev Med"},{"issue":"3","key":"zoi210349r28","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/infdis\/jix275","article-title":"Determining the seasonality of respiratory syncytial virus in the United States: the impact of increased molecular testing.","volume":"216","author":"Midgley","year":"2017","journal-title":"J Infect Dis"},{"issue":"33","key":"zoi210349r29","first-page":"1057","article-title":"Estimates of deaths associated with seasonal influenza\u2014United States, 1976-2007.","volume":"59","author":"Centers for Disease Control and Prevention (CDC)","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"2","key":"zoi210349r30","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1086\/648977","article-title":"Influenza circulation and the burden of invasive pneumococcal pneumonia during a non-pandemic period in the United States.","volume":"50","author":"Walter","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"1","key":"zoi210349r31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/irv.2009.3.issue-1","article-title":"Estimates of US influenza-associated deaths made using four different methods.","volume":"3","author":"Thompson","year":"2009","journal-title":"Influenza Other Respir Viruses"},{"issue":"1","key":"zoi210349r32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169344","article-title":"The annual burden of seasonal influenza in the US Veterans Affairs population.","volume":"12","author":"Young-Xu","year":"2017","journal-title":"PLoS One"},{"issue":"11","key":"zoi210349r35","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1001\/jama.292.11.1333","article-title":"Influenza-associated hospitalizations in the United States.","volume":"292","author":"Thompson","year":"2004","journal-title":"JAMA"},{"key":"zoi210349r37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2019.103998","article-title":"Aging and influenza vaccine-induced immunity.","volume":"348","author":"Dugan","year":"2020","journal-title":"Cell Immunol"},{"issue":"2","key":"zoi210349r38","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1128\/CVI.00580-12","article-title":"Adults 65 years old and older have reduced numbers of functional memory T cells to respiratory syncytial virus fusion protein.","volume":"20","author":"Cherukuri","year":"2013","journal-title":"Clin Vaccine Immunol"},{"issue":"4","key":"zoi210349r39","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1001\/jamacardio.2019.0549","article-title":"Association of influenza-like illness activity with hospitalizations for heart failure: the Atherosclerosis Risk in Communities Study.","volume":"4","author":"Kyt\u00f6maa","year":"2019","journal-title":"JAMA Cardiol"},{"issue":"10","key":"zoi210349r40","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1310\/hpj4810-813","article-title":"Influenza vaccine for cardiovascular risk reduction.","volume":"48","author":"Howard","year":"2013","journal-title":"Hosp Pharm"},{"issue":"5","key":"zoi210349r41","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1161\/CIRCULATIONAHA.118.036788","article-title":"Influenza vaccine in heart failure: cumulative number of vaccinations, frequency, timing, and survival\u2014a Danish nationwide cohort study.","volume":"139","author":"Modin","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"zoi210349r42","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1056\/NEJMoa1702090","article-title":"Acute myocardial infarction after laboratory-confirmed influenza infection.","volume":"378","author":"Kwong","year":"2018","journal-title":"N Engl J Med"},{"issue":"147","key":"zoi210349r43","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0103-2017","article-title":"Exacerbations of COPD.","volume":"27","author":"Viniol","year":"2018","journal-title":"Eur Respir Rev"},{"issue":"6","key":"zoi210349r44","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/all.2018.73.issue-6","article-title":"Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in Asthma Task Force.","volume":"73","author":"Schwarze","year":"2018","journal-title":"Allergy"},{"issue":"2","key":"zoi210349r45","article-title":"Vaccines for preventing influenza in people with asthma.","author":"Cates","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"zoi210349r46","article-title":"Influenza vaccine for chronic obstructive pulmonary disease (COPD).","volume":"6","author":"Kopsaftis","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"23","key":"zoi210349r47","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1016\/j.jacc.2011.10.824","article-title":"AHA\/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation endorsed by the World Heart Federation and the Preventive Cardiovascular Nurses Association.","volume":"58","author":"Smith","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"zoi210349r48","doi-asserted-by":"publisher","first-page":"E01","DOI":"10.1097\/PHH.0b013e3181c60ed4","article-title":"Evaluation of a legislatively mandated influenza vaccination program for adults in Rhode Island, USA.","volume":"16","author":"Ahmed","year":"2010","journal-title":"J Public Health Manag Pract"},{"key":"zoi210349r36","volume-title":"Healthcare Cost and Utilization Project (HCUP) Statistical Briefs","author":"Fingar","year":"2019"},{"key":"zoi210349r49","volume-title":"National Variation in Hospitalization and Emergency Department\/Observation Visits for Medicare Beneficiaries Receiving Long-term Care in Nursing Centers","author":"Kramer","year":"2017"},{"key":"zoi210349r3","unstructured":"Rolfes? MA, Foppa? IM, Garg? S, . 2015-2016 Estimated influenza illnesses, medical visits, hospitalizations, and deaths averted by vaccination in the United States. Accessed April 3, 2021. https:\/\/www.cdc.gov\/flu\/about\/disease\/2015-16.htm"},{"key":"zoi210349r33","unstructured":"Bureau of Economic Analysis. National income and product accounts: tables. Accessed April 4, 2021. https:\/\/apps.bea.gov\/iTable\/iTable.cfm?reqid=19&step=2#reqid=19&step=2&isuri=1&1921=survey"},{"key":"zoi210349r34","unstructured":"McConeghy KW, van Aalst R, Zullo A, Joyce N. Flumodelr: an R package for estimating attributable influenza morbidity and mortality. Accessed September 23, 2020. https:\/\/kmcconeghy.github.io\/flumodelr\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2780800\/bosco_2021_oi_210349_1622574021.84872.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T15:15:05Z","timestamp":1623251705000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2780800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.11806","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]}}}