{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:05:23Z","timestamp":1789524323072,"version":"build-2803163510"},"reference-count":45,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2021.17573","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T11:31:14Z","timestamp":1627039874000},"page":"e2117573","source":"Crossref","is-referenced-by-count":100,"title":["Association of Sleep and \u03b2-Amyloid Pathology Among Older Cognitively Unimpaired Adults"],"prefix":"10.1001","volume":"4","author":[{"given":"Philip S.","family":"Insel","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco"},{"name":"Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Mohlenhoff","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco"},{"name":"Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Neylan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco"},{"name":"Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Krystal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Scott","family":"Mackin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco"},{"name":"Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"issue":"7","key":"zoi210524r1","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/nn.4035","article-title":"\u00df-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.","volume":"18","author":"Mander","year":"2015","journal-title":"Nat Neurosci"},{"issue":"6315","key":"zoi210524r2","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1126\/science.aah4968","article-title":"Mechanisms linking circadian clocks, sleep, and neurodegeneration.","volume":"354","author":"Musiek","year":"2016","journal-title":"Science"},{"issue":"12","key":"zoi210524r3","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1001\/jamaneurol.2014.2510","article-title":"Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease.","volume":"71","author":"Liguori","year":"2014","journal-title":"JAMA Neurol"},{"key":"zoi210524r4","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117676","article-title":"Time between milestone events in the Alzheimer\u2019s disease amyloid cascade.","volume":"227","author":"Insel","year":"2021","journal-title":"Neuroimage"},{"issue":"4","key":"zoi210524r5","doi-asserted-by":"publisher","first-page":"e322","DOI":"10.1212\/WNL.0000000000007831","article-title":"Determining clinically meaningful decline in preclinical Alzheimer disease.","volume":"93","author":"Insel","year":"2019","journal-title":"Neurology"},{"issue":"1","key":"zoi210524r6","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1001\/archneurol.2011.235","article-title":"Effects of age and amyloid deposition on A\u00df dynamics in the human central nervous system.","volume":"69","author":"Huang","year":"2012","journal-title":"Arch Neurol"},{"issue":"4","key":"zoi210524r7","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s11064-019-02719-2","article-title":"Chronic sleep restriction induces A\u00df accumulation by disrupting the balance of A\u00df production and clearance in rats.","volume":"44","author":"Zhao","year":"2019","journal-title":"Neurochem Res"},{"issue":"6156","key":"zoi210524r8","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain.","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"issue":"6512","key":"zoi210524r9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia.","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"issue":"1","key":"zoi210524r10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/ana.25117","article-title":"Effect of sleep on overnight cerebrospinal fluid amyloid \u00df kinetics.","volume":"83","author":"Lucey","year":"2018","journal-title":"Ann Neurol"},{"issue":"8","key":"zoi210524r11","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1093\/brain\/awx148","article-title":"Slow wave sleep disruption increases cerebrospinal fluid amyloid-\u00df levels.","volume":"140","author":"Ju","year":"2017","journal-title":"Brain"},{"issue":"5955","key":"zoi210524r12","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.","volume":"326","author":"Kang","year":"2009","journal-title":"Science"},{"issue":"8","key":"zoi210524r13","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1093\/brain\/awx174","article-title":"A restless night makes for a rising tide of amyloid.","volume":"140","author":"Mander","year":"2017","journal-title":"Brain"},{"issue":"5","key":"zoi210524r14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsy025","article-title":"Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer\u2019s disease.","volume":"41","author":"Olsson","year":"2018","journal-title":"Sleep"},{"issue":"12","key":"zoi210524r15","first-page":"1537","article-title":"Self-reported sleep and \u00df-amyloid deposition in community-dwelling older adults.","volume":"70","author":"Spira","year":"2013","journal-title":"JAMA Neurol"},{"issue":"17","key":"zoi210524r16","doi-asserted-by":"publisher","first-page":"4483","DOI":"10.1073\/pnas.1721694115","article-title":"\u00df-Amyloid accumulation in the human brain after one night of sleep deprivation.","volume":"115","author":"Shokri-Kojori","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"zoi210524r17","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.13383","article-title":"Association of \u00df-amyloid burden with sleep dysfunction and cognitive impairment in elderly individuals with cognitive disorders.","volume":"2","author":"You","year":"2019","journal-title":"JAMA Netw Open"},{"key":"zoi210524r18","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3389\/fneur.2019.00989","article-title":"Absence of relationship between self-reported sleep measures and amyloid load in elderly subjects.","volume":"10","author":"Gabelle","year":"2019","journal-title":"Front Neurol"},{"issue":"9","key":"zoi210524r19","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1016\/j.neurobiolaging.2015.05.004","article-title":"Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults.","volume":"36","author":"Sprecher","year":"2015","journal-title":"Neurobiol Aging"},{"key":"zoi210524r20","doi-asserted-by":"crossref","DOI":"10.1177\/2050312114546520","article-title":"Objectively measured sleep and \u00df-amyloid burden in older adults: A pilot study.","volume":"2","author":"Spira","year":"2014","journal-title":"SAGE Open Med"},{"key":"zoi210524r21","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neubiorev.2017.01.032","article-title":"Cooccurrence and bidirectional prediction of sleep disturbances and depression in older adults: Meta-analysis and systematic review.","volume":"75","author":"Bao","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"zoi210524r22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.smrv.2007.07.004","article-title":"Caffeine: sleep and daytime sleepiness.","volume":"12","author":"Roehrs","year":"2008","journal-title":"Sleep Med Rev"},{"key":"zoi210524r23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cpr.2018.11.002","article-title":"Does exercise improve sleep for adults with insomnia? a systematic review with quality appraisal.","volume":"68","author":"Lowe","year":"2019","journal-title":"Clin Psychol Rev"},{"issue":"228","key":"zoi210524r24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007941","article-title":"The A4 study: stopping AD before symptoms begin?","volume":"6","author":"Sperling","year":"2014","journal-title":"Sci Transl Med"},{"issue":"6","key":"zoi210524r25","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1001\/jamaneurol.2020.0387","article-title":"Association of factors with elevated amyloid burden in clinically normal older individuals.","volume":"77","author":"Sperling","year":"2020","journal-title":"JAMA Neurol"},{"issue":"5","key":"zoi210524r26","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/acn3.v7.5","article-title":"The A4 study: \u00df-amyloid and cognition in 4432 cognitively unimpaired adults.","volume":"7","author":"Insel","year":"2020","journal-title":"Ann Clin Transl Neurol"},{"key":"zoi210524r27","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.jalz.2018.07.144","article-title":"Tau PET in A4: preliminary report.","volume":"14","author":"Johnson","year":"2018","journal-title":"Alzheimers Dement."},{"issue":"3","key":"zoi210524r28","doi-asserted-by":"publisher","first-page":"378","DOI":"10.2967\/jnumed.111.090340","article-title":"Performance characteristics of amyloid PET with florbetapir F 18 in patients with alzheimer\u2019s disease and cognitively normal subjects.","volume":"53","author":"Joshi","year":"2012","journal-title":"J Nucl Med"},{"issue":"8","key":"zoi210524r29","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/S1474-4422(12)70142-4","article-title":"Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-\u00df plaques: a prospective cohort study.","volume":"11","author":"Clark","year":"2012","journal-title":"Lancet Neurol"},{"issue":"2","key":"zoi210524r31","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/(ISSN)1097-0258","article-title":"Multivariate longitudinal models for complex change processes.","volume":"23","author":"Beckett","year":"2004","journal-title":"Stat Med"},{"issue":"2","key":"zoi210524r32","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure.","volume":"6","author":"Holm","year":"1979","journal-title":"Scand J Stat"},{"issue":"1","key":"zoi210524r34","doi-asserted-by":"publisher","first-page":"a007","DOI":"10.1093\/braincomms\/fcaa007","article-title":"Neuroanatomical spread of amyloid \u00df and tau in Alzheimer\u2019s disease: implications for primary prevention.","volume":"2","author":"Insel","year":"2020","journal-title":"Brain Commun"},{"issue":"9","key":"zoi210524r35","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.5664\/jcsm.7342","article-title":"Total sleep time interacts with age to predict cognitive performance among adults.","volume":"14","author":"Mohlenhoff","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"10","key":"zoi210524r36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsy152","article-title":"Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET.","volume":"41","author":"Spira","year":"2018","journal-title":"Sleep"},{"issue":"6","key":"zoi210524r37","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1001\/jamaneurol.2018.0049","article-title":"Association of excessive daytime sleepiness with longitudinal \u00df-Amyloid accumulation in elderly persons without dementia.","volume":"75","author":"Carvalho","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"zoi210524r38","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","article-title":"Earliest accumulation of \u00df-amyloid occurs within the default-mode network and concurrently affects brain connectivity.","volume":"8","author":"Palmqvist","year":"2017","journal-title":"Nat Commun"},{"issue":"6","key":"zoi210524r39","first-page":"630","article-title":"NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.","volume":"25","author":"Krystal","year":"2002","journal-title":"Sleep"},{"issue":"4","key":"zoi210524r40","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/sleep\/zsx021","article-title":"The association between sleep duration and hand grip strength in community-dwelling older adults: The Yilan Study.","volume":"40","author":"Chen","year":"2017","journal-title":"Sleep"},{"issue":"9","key":"zoi210524r41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsz137","article-title":"Relationships between objectives sleep parameters and brain amyloid load in subjects at risk for Alzheimer\u2019s disease: the INSIGHT-preAD Study.","volume":"42","author":"Ettore","year":"2019","journal-title":"Sleep"},{"issue":"32","key":"zoi210524r42","doi-asserted-by":"publisher","first-page":"6315","DOI":"10.1523\/JNEUROSCI.0503-19.2019","article-title":"Sleep as a potential biomarker of tau and \u00df-amyloid burden in the human brain.","volume":"39","author":"Winer","year":"2019","journal-title":"J Neurosci"},{"issue":"1","key":"zoi210524r43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3233\/JAD-161047","article-title":"Amyloid burden in obstructive sleep apnea.","volume":"59","author":"Yun","year":"2017","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"zoi210524r44","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1093\/sleep\/18.8.646","article-title":"Subjective estimates of sleep differ from polysomnographic measurements in obstructive sleep apnea patients.","volume":"18","author":"McCall","year":"1995","journal-title":"Sleep"},{"issue":"10","key":"zoi210524r45","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.jalz.2019.06.3916","article-title":"Profound degeneration of wake-promoting neurons in Alzheimer\u2019s disease.","volume":"15","author":"Oh","year":"2019","journal-title":"Alzheimers Dement"},{"key":"zoi210524r30","doi-asserted-by":"crossref","DOI":"10.1002\/0471725250","volume-title":"Robust Statistics.","author":"Huber","year":"1981"},{"key":"zoi210524r33","doi-asserted-by":"crossref","unstructured":"Sch\u00e4fer? T, Ecker? C.? fsbrain: an R package for the visualization of structural neuroimaging data.? bioRxiv. 2020:9-10. doi:10.1101\/2020.09.18.302935?","DOI":"10.1101\/2020.09.18.302935"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2782215\/insel_2021_oi_210524_1626356082.8753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T11:31:27Z","timestamp":1627039887000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2782215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.17573","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]}}}