{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:28:02Z","timestamp":1792517282857,"version":"4.5.0"},"reference-count":34,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2021.20603","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T11:34:17Z","timestamp":1628854457000},"page":"e2120603","source":"Crossref","is-referenced-by-count":82,"title":["Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic"],"prefix":"10.1001","volume":"4","author":[{"given":"Jos\u00e9 Alexandre S.","family":"Crippa","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"},{"name":"National Institute for Science and Technology\u2013Translational Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio W.","family":"Zuardi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"},{"name":"National Institute for Science and Technology\u2013Translational Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco S.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"National Institute for Science and Technology\u2013Translational Medicine, S\u00e3o Paulo, Brazil"},{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alline Cristina","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via","family":"de Lima Os\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"},{"name":"National Institute for Science and Technology\u2013Translational Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Regina","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael G.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"},{"name":"National Institute for Science and Technology\u2013Translational Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Diogo S.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Mayumi","family":"Ushirohira","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Cozar","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Rinaldi","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Cristinne","family":"Mancini Costa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davi Silveira","family":"Scomparin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciele Franco","family":"Scarante","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Pires-Dos-Santos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Mechoulam","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio","family":"Kapczinski","sequence":"additional","affiliation":[{"name":"National Institute for Science and Technology\u2013Translational Medicine, S\u00e3o Paulo, Brazil"},{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Psychiatry, Faculty of Medicine, Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedito A. L.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danillo L. A.","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Pereira-Lima","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Michigan Medical School, Ann Arbor"},{"name":"Department of Psychiatry, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijan","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Michigan Medical School, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristela Haddad","family":"Andraus","sequence":"additional","affiliation":[{"name":"Chromatox Laboratory, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E. C.","family":"Hallak","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"},{"name":"National Institute for Science and Technology\u2013Translational Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Burnout and Distress Prevention With Cannabidiol in Front-line Health Care Workers Dealing With COVID-19 (BONSAI) Trial Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PD","given":"Debora C.","family":"Litcanov","sequence":"additional","affiliation":[{"name":"for the Burnout and Distress Prevention With Cannabidiol in Front-line Health Care Workers Dealing With COVID-19 (BONSAI) Trial Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PD","given":"Leonardo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"for the Burnout and Distress Prevention With Cannabidiol in Front-line Health Care Workers Dealing With COVID-19 (BONSAI) Trial Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PD","given":"Thiago F.","family":"Alves","sequence":"additional","affiliation":[{"name":"for the Burnout and Distress Prevention With Cannabidiol in Front-line Health Care Workers Dealing With COVID-19 (BONSAI) Trial Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PD","given":"B\u00e1rbara M.","family":"Coutinho","sequence":"additional","affiliation":[{"name":"for the Burnout and Distress Prevention With Cannabidiol in Front-line Health Care Workers Dealing With COVID-19 (BONSAI) Trial Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"issue":"3","key":"zoi210605r1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S2215-0366(20)30046-8","article-title":"Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed.","volume":"7","author":"Xiang","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"zoi210605r2","author":"Iob","year":"2020"},{"key":"zoi210605r3","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.bbi.2020.05.040","article-title":"Mental health consequences during the initial stage of the 2020 coronavirus pandemic (COVID-19) in Spain.","volume":"87","author":"Gonzalez-Sanguino","year":"2020","journal-title":"Brain Behav Immun"},{"key":"zoi210605r4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bbi.2020.05.004","article-title":"Letter to the editor \u201cA longitudinal study on the mental health of general population during the COVID-19 epidemic in China\u201d.","volume":"87","author":"Ren","year":"2020","journal-title":"Brain Behav Immun"},{"key":"zoi210605r5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2020.05.009","article-title":"Prevalence and correlates of PTSD and depressive symptoms one month after the outbreak of the COVID-19 epidemic in a sample of home-quarantined Chinese university students.","volume":"274","author":"Tang","year":"2020","journal-title":"J Affect Disord"},{"key":"zoi210605r6","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.bbi.2020.05.026","article-title":"Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: a systematic review and meta-analysis.","volume":"88","author":"Pappa","year":"2020","journal-title":"Brain Behav Immun"},{"issue":"11","key":"zoi210605r7","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1038\/s41386-020-0667-2","article-title":"Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials.","volume":"45","author":"Chesney","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"zoi210605r8","author":"Crippa","year":"2018"},{"key":"zoi210605r9","author":"Zuardi","year":"2017"},{"issue":"3","key":"zoi210605r10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s40429-020-00326-8","article-title":"Therapeutic efficacy of cannabidiol (CBD): a review of the evidence from clinical trials and human laboratory studies.","volume":"7","author":"Sholler","year":"2020","journal-title":"Curr Addict Rep"},{"issue":"6","key":"zoi210605r11","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/npp.2011.6","article-title":"Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients.","volume":"36","author":"Bergamaschi","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"zoi210605r12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1476-5381.2009.00521.x","article-title":"Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.","volume":"159","author":"Zanelati","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"11","key":"zoi210605r13","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/j.jpsychires.2012.08.012","article-title":"Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors.","volume":"46","author":"Campos","year":"2012","journal-title":"J Psychiatr Res"},{"issue":"6","key":"zoi210605r14","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1017\/S1461145712001502","article-title":"The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.","volume":"16","author":"Campos","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"zoi210605r15","author":"Khodadadi","year":"2020"},{"issue":"21","key":"zoi210605r16","doi-asserted-by":"publisher","first-page":"12869","DOI":"10.1111\/jcmm.v24.21","article-title":"Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome.","volume":"24","author":"Salles","year":"2020","journal-title":"J Cell Mol Med"},{"key":"zoi210605r17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.nbd.2013.06.016","article-title":"Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors.","volume":"59","author":"Mecha","year":"2013","journal-title":"Neurobiol Dis"},{"key":"zoi210605r18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.neuroscience.2014.12.051","article-title":"Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria.","volume":"289","author":"Campos","year":"2015","journal-title":"Neuroscience"},{"issue":"3","key":"zoi210605r19","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/glia.v68.3","article-title":"Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS\/NF-?B-dependent signaling and glucose consumption.","volume":"68","author":"Dos-Santos-Pereira","year":"2020","journal-title":"Glia"},{"key":"zoi210605r20","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.bbi.2018.09.014","article-title":"Cannabidiol prevents haloperidol-induced vacuos chewing movements and inflammatory changes in mice via PPAR? receptors.","volume":"74","author":"Sonego","year":"2018","journal-title":"Brain Behav Immun"},{"key":"zoi210605r21","article-title":"Psychometrics properties of Maslach Burnout Inventory in a multifunctional sample.","author":"Carlotto","year":"2007"},{"key":"zoi210605r22"},{"key":"zoi210605r24"},{"key":"zoi210605r25"},{"issue":"1","key":"zoi210605r26","doi-asserted-by":"publisher","first-page":"367","DOI":"10.9788\/TP2016.1-25","article-title":"Factor structure, reliability, and item parameters of the Brazilian-Portuguese version of the GAD-7 questionnaire.","volume":"24","author":"Moreno","journal-title":"Temas em Psicologia"},{"issue":"3","key":"zoi210605r27","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/ppc.2009.45.issue-3","article-title":"Study of the discriminative validity of the PHQ-9 and PHQ-2 in a sample of Brazilian women in the context of primary health care.","volume":"45","author":"de Lima Osorio","year":"2009","journal-title":"Perspect Psychiatr Care"},{"issue":"1","key":"zoi210605r28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1590\/0101-60830000000107","article-title":"Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): transcultural adaptation of the Brazilian version.","volume":"44","author":"Osorio","year":"2017","journal-title":"Archives of Clinical Psychiatry"},{"issue":"3","key":"zoi210605r29","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1590\/S1516-44462007000300010","article-title":"The Portuguese version of the Clinical Global Impression\u2013Schizophrenia Scale: validation study.","volume":"29","author":"de Lima","year":"2007","journal-title":"Braz J Psychiatry"},{"key":"zoi210605r30","article-title":"Just text me: using SMS technology for collaborative patient mood charting.","volume":"3","author":"Foreman","year":"2011","journal-title":"J Particip Med"},{"issue":"6","key":"zoi210605r31","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1097\/01.psy.0000239247.47581.0c","article-title":"Immune and endocrine function in burnout syndrome.","volume":"68","author":"Mommersteeg","year":"2006","journal-title":"Psychosom Med"},{"issue":"9","key":"zoi210605r32","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression.","volume":"65","author":"Miller","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"11","key":"zoi210605r33","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/da.2018.35.issue-11","article-title":"The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation: a systematic review and meta-analysis.","volume":"35","author":"Renna","year":"2018","journal-title":"Depress Anxiety"},{"key":"zoi210605r34","doi-asserted-by":"crossref","DOI":"10.1590\/1806-9282.65.3.361","article-title":"Increased levels of plasma IL-1b and BDNF can predict resistant depression patients.","author":"Uint","year":"2019"},{"key":"zoi210605r23","unstructured":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. ICH Harmonised Tripartite Guideline. Guideline for Good Clinical Practice E6 (R1). June 10, 1996. Accessed July 1, 2021. https:\/\/apps.who.int\/medicinedocs\/documents\/s22154en\/s22154en.pdf"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2782994\/crippa_2021_oi_210605_1628614611.5253.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T11:34:20Z","timestamp":1628854460000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2782994"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.20603","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]}}}