{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:43:24Z","timestamp":1793727804955,"version":"4.6.1"},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2021.28817","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T15:33:51Z","timestamp":1635435231000},"page":"e2128817","source":"Crossref","is-referenced-by-count":119,"title":["Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels"],"prefix":"10.1001","volume":"4","author":[{"given":"Aparna","family":"Sajja","sequence":"first","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanth","family":"Sathiyakumar","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibin","family":"Varghese","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Pallazola","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise A.","family":"Marvel","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnaji","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"VAP Diagnostics Lab, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alagarraju","family":"Muthukumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag H.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, University of Texas \/Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Gianos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Shore University Hospital, Northwell Health, Zucker School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hirsh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Shore University Hospital, Northwell Health, Zucker School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Mintz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Shore University Hospital, Northwell Health, Zucker School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela B.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of South Carolina, Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Sharma","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Michos","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed B.","family":"Elshazly","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Cardiovascular Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"issue":"25","key":"zoi210844r1","first-page":"e1082","volume":"139","author":"Grundy","year":"2019","journal-title":"Circulation"},{"issue":"1","key":"zoi210844r2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1812792","article-title":"Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia.","volume":"380","author":"Bhatt","year":"2019","journal-title":"N Engl J Med"},{"issue":"18","key":"zoi210844r3","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease.","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"zoi210844r4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"issue":"19","key":"zoi210844r5","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1001\/jama.2013.280532","article-title":"Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile.","volume":"310","author":"Martin","year":"2013","journal-title":"JAMA"},{"issue":"6","key":"zoi210844r6","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"zoi210844r7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cca.2020.03.030","article-title":"More accurate LDL-C calculation: externally validated, guideline endorsed.","volume":"506","author":"Brownstein","year":"2020","journal-title":"Clin Chim Acta"},{"issue":"11","key":"zoi210844r8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/clc.22214","article-title":"Very Large Database of Lipids: rationale and design.","volume":"36","author":"Martin","year":"2013","journal-title":"Clin Cardiol"},{"issue":"4","key":"zoi210844r9","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.cll.2006.07.004","article-title":"Cholesterol profile measurement by vertical auto profile method.","volume":"26","author":"Kulkarni","year":"2006","journal-title":"Clin Lab Med"},{"issue":"5","key":"zoi210844r10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1001\/jamacardio.2020.0013","article-title":"A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and\/or hypertriglyceridemia.","volume":"5","author":"Sampson","year":"2020","journal-title":"JAMA Cardiol"},{"issue":"Pt 1","key":"zoi210844r11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1258\/acb.2012.011259","article-title":"A new accurate, simple formula for LDL-cholesterol estimation based on directly measured blood lipids from a large cohort.","volume":"50","author":"de Cordova","year":"2013","journal-title":"Ann Clin Biochem"},{"issue":"3","key":"zoi210844r12","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22057","article-title":"Calculation of LDL-cholesterol vs. direct homogenous assay.","volume":"31","author":"Rasouli","year":"2017","journal-title":"J Clin Lab Anal"},{"issue":"10","key":"zoi210844r13","first-page":"961","article-title":"Evaluation of alternative calculation methods for determining LDL cholesterol.","volume":"54","author":"Vohnout","year":"2008","journal-title":"Vnitr Lek"},{"issue":"11","key":"zoi210844r14","first-page":"1981","article-title":"Ratio of remnant-like particle-cholesterol to serum total triglycerides is an effective alternative to ultracentrifugal and electrophoretic methods in the diagnosis of familial type III hyperlipoproteinemia.","volume":"45","author":"Wang","year":"1999","journal-title":"Clin Chem"},{"issue":"9","key":"zoi210844r15","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s11883-014-0440-2","article-title":"Hyperlipoproteinemia type 3: the forgotten phenotype.","volume":"16","author":"Hopkins","year":"2014","journal-title":"Curr Atheroscler Rep"},{"issue":"1","key":"zoi210844r16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148147","article-title":"Validation of the Martin method for estimating low-density lipoprotein cholesterol levels in Korean adults: findings from the Korea National Health and Nutrition Examination Survey, 2009-2011.","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"zoi210844r17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.4082\/kjfm.2017.38.5.263","article-title":"Martin\u2019s equation as the most suitable method for estimation of low-density lipoprotein cholesterol levels in Korean adults.","volume":"38","author":"Kang","year":"2017","journal-title":"Korean J Fam Med"},{"issue":"12","key":"zoi210844r19","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.5551\/jat.35972","article-title":"Validity of a novel method for estimation of low-density lipoprotein cholesterol levels in diabetic patients.","volume":"23","author":"Chaen","year":"2016","journal-title":"J Atheroscler Thromb"},{"issue":"4","key":"zoi210844r20","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1515\/cclm-2019-1253","article-title":"Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM.","volume":"58","author":"Langlois","year":"2020","journal-title":"Clin Chem Lab Med"},{"issue":"7","key":"zoi210844r22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1161\/CIRCULATIONAHA.114.010001","article-title":"Prognostic value of fasting versus nonfasting low-density lipoprotein cholesterol levels on long-term mortality: insight from the National Health and Nutrition Examination Survey III (NHANES-III).","volume":"130","author":"Doran","year":"2014","journal-title":"Circulation"},{"issue":"1","key":"zoi210844r23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1161\/CIRCULATIONAHA.117.030677","article-title":"Fasting versus nonfasting and low-density lipoprotein cholesterol accuracy.","volume":"137","author":"Sathiyakumar","year":"2018","journal-title":"Circulation"},{"key":"zoi210844r24","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","author":"Arnett","year":"2019","journal-title":"Circulation"},{"issue":"17","key":"zoi210844r25","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1056\/NEJMp1508120","article-title":"Reducing LDL with PCSK9 inhibitors\u2013the clinical benefit of lipid drugs.","volume":"373","author":"Everett","year":"2015","journal-title":"N Engl J Med"},{"issue":"10215","key":"zoi210844r26","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1016\/S0140-6736(19)32519-X","article-title":"Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium.","volume":"394","author":"Brunner","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"zoi210844r27","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.jacl.2017.05.005","article-title":"Evaluating the atherogenic burden of individuals with a Friedewald-estimated low-density lipoprotein cholesterol <70 mg\/dL compared with a novel low-density lipoprotein estimation method.","volume":"11","author":"Whelton","year":"2017","journal-title":"J Clin Lipidol"},{"issue":"4","key":"zoi210844r28","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306249","article-title":"Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology.","volume":"118","author":"Nordestgaard","year":"2016","journal-title":"Circ Res"},{"issue":"3","key":"zoi210844r29","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0022-2275(20)39807-2","article-title":"Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor.","volume":"21","author":"Chung","year":"1980","journal-title":"J Lipid Res"},{"key":"zoi210844r30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0076-6879(86)28068-4","article-title":"Single vertical spin density gradient ultracentrifugation.","volume":"128","author":"Chung","year":"1986","journal-title":"Methods Enzymol"},{"key":"zoi210844r18","unstructured":"QuestDiagnostics. A new LDL-C testing standard for cardiac risk assessment offering increased accuracy and convenience. Accessed September 30, 2021.  https:\/\/www.questdiagnostics.com\/home\/patients\/health-test-info\/chronic-disease\/heart-disease\/Martin-Hopkins\/"},{"key":"zoi210844r21","unstructured":"Johns Hopkins Medicine. LDL calculator. Accessed September 30, 2021. https:\/\/www.ldlcalculator.com"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2785570\/sajja_2021_oi_210844_1634830858.61649.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T15:34:01Z","timestamp":1635435241000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2785570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.28817","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,28]]}}}