{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:37:21Z","timestamp":1788878241160,"version":"build-2803163510"},"reference-count":28,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2021.4552","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T22:50:30Z","timestamp":1619131830000},"page":"e214552","source":"Crossref","is-referenced-by-count":41,"title":["Trajectories of Opioid Use Following First Opioid Prescription in Opioid-Naive Youths and Young Adults"],"prefix":"10.1001","volume":"4","author":[{"given":"J. Deanna","family":"Wilson","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleab Z.","family":"Abebe","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Liebschutz","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Merlin","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kelley","sequence":"additional","affiliation":[{"name":"Pennsylvania Office of Medical Assistance Programs, Harrisburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Donohue","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"issue":"2","key":"zoi210165r1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.0217","article-title":"The burden of opioid-related mortality in the United States.","volume":"1","author":"Gomes","year":"2018","journal-title":"JAMA Netw Open"},{"issue":"4","key":"zoi210165r2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-2387","article-title":"Trends in medical and nonmedical use of prescription opioids among US adolescents: 1976-2015.","volume":"139","author":"McCabe","year":"2017","journal-title":"Pediatrics"},{"issue":"8","key":"zoi210165r3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.6161","article-title":"Trends in opioid use in pediatric patients in US emergency departments from 2006 to 2015.","volume":"1","author":"Tomaszewski","year":"2018","journal-title":"JAMA Netw Open"},{"issue":"6","key":"zoi210165r4","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-1578","article-title":"Trends in opioid prescribing for adolescents and young adults in ambulatory care settings.","volume":"143","author":"Hudgins","year":"2019","journal-title":"Pediatrics"},{"issue":"2","key":"zoi210165r5","first-page":"21","article-title":"Adolescent brain development and drugs.","volume":"18","author":"Winters","year":"2011","journal-title":"Prev Res"},{"issue":"1","key":"zoi210165r6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1177\/155005940904000110","article-title":"The influence of substance use on adolescent brain development.","volume":"40","author":"Squeglia","year":"2009","journal-title":"Clin EEG Neurosci"},{"issue":"12","key":"zoi210165r7","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1111\/add.2007.102.issue-12","article-title":"Does early onset of non-medical use of prescription drugs predict subsequent prescription drug abuse and dependence? Results from a national study.","volume":"102","author":"McCabe","year":"2007","journal-title":"Addiction"},{"issue":"1","key":"zoi210165r8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr6501e1","article-title":"CDC guideline for prescribing opioids for chronic pain\u2014United States, 2016.","volume":"65","author":"Dowell","year":"2016","journal-title":"MMWR Recomm Rep"},{"issue":"1","key":"zoi210165r9","first-page":"72","article-title":"Opioid use in children.","volume":"24","author":"Matson","year":"2019","journal-title":"J Pediatr Pharmacol Ther"},{"issue":"13","key":"zoi210165r11","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1056\/NEJMra1507771","article-title":"Opioid abuse in chronic pain\u2014misconceptions and mitigation strategies.","volume":"374","author":"Volkow","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"zoi210165r12","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1001\/archpsyc.64.5.566","article-title":"Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions.","volume":"64","author":"Compton","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"zoi210165r13","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1097\/j.pain.0000000000000624","article-title":"Adolescent context of exposure to prescription opioids and substance use disorder symptoms at age 35: a national longitudinal study.","volume":"157","author":"McCabe","year":"2016","journal-title":"Pain"},{"issue":"9","key":"zoi210165r14","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1001\/archpediatrics.2012.85","article-title":"Medical and nonmedical use of prescription opioids among high school seniors in the United States.","volume":"166","author":"McCabe","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"zoi210165r15","doi-asserted-by":"publisher","first-page":"e1169","DOI":"10.1542\/peds.2015-1364","article-title":"Prescription opioids in adolescence and future opioid misuse.","volume":"136","author":"Miech","year":"2015","journal-title":"Pediatrics"},{"issue":"6","key":"zoi210165r16","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1542\/peds.2006-1644","article-title":"Adolescents\u2019 motivations to abuse prescription medications.","volume":"118","author":"Boyd","year":"2006","journal-title":"Pediatrics"},{"issue":"1","key":"zoi210165r17","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-2439","article-title":"Persistent opioid use among pediatric patients after surgery.","volume":"141","author":"Harbaugh","year":"2018","journal-title":"Pediatrics"},{"issue":"9","key":"zoi210165r18","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2019.1750","article-title":"Association of nonmedical prescription opioid use with subsequent heroin use initiation in adolescents.","volume":"173","author":"Kelley-Quon","year":"2019","journal-title":"JAMA Pediatr"},{"issue":"13","key":"zoi210165r19","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1001\/jama.2011.370","article-title":"Association between opioid prescribing patterns and opioid overdose-related deaths.","volume":"305","author":"Bohnert","year":"2011","journal-title":"JAMA"},{"issue":"14","key":"zoi210165r20","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1001\/jama.2015.11859","article-title":"Nonmedical prescription opioid use and use disorders among adults aged 18 through 64 years in the United States, 2003-2013.","volume":"314","author":"Han","year":"2015","journal-title":"JAMA"},{"issue":"4","key":"zoi210165r21","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1001\/jamainternmed.2014.8071","article-title":"Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy.","volume":"175","author":"Miller","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"7","key":"zoi210165r22","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1111\/pme.v16.7","article-title":"The burden of undiagnosed opioid abuse among commercially insured individuals.","volume":"16","author":"Kirson","year":"2015","journal-title":"Pain Med"},{"issue":"8","key":"zoi210165r23","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1001\/jamapediatrics.2017.0745","article-title":"Trends in receipt of buprenorphine and naltrexone for opioid use disorder among adolescent and young adults, 2001\u20132014.","volume":"171","author":"Hadland","year":"2017","journal-title":"JAMA Pediatr"},{"key":"zoi210165r24","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.drugalcdep.2015.04.010","article-title":"Opioid abuse and depression in adolescents: results from the National Survey on Drug Use and Health.","volume":"152","author":"Edlund","year":"2015","journal-title":"Drug Alcohol Depend"},{"issue":"3","key":"zoi210165r25","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1080\/08897077.2014.928660","article-title":"Psychological and drug abuse symptoms associated with nonmedical use of opioid analgesics among adolescents.","volume":"35","author":"Boyd","year":"2014","journal-title":"Subst Abus"},{"issue":"5","key":"zoi210165r26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.annemergmed.2014.11.015","article-title":"Association of emergency department opioid initiation with recurrent opioid use.","volume":"65","author":"Hoppe","year":"2015","journal-title":"Ann Emerg Med"},{"issue":"1","key":"zoi210165r27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/PEC.0000000000001239","article-title":"Opioid prescribing practices in pediatric acute care settings.","volume":"35","author":"DePhillips","year":"2019","journal-title":"Pediatr Emerg Care"},{"issue":"9","key":"zoi210165r28","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1176\/appi.ps.201700562","article-title":"Opioid prescribing to adolescents in the United States from 2005 to 2016.","volume":"69","author":"Henke","year":"2018","journal-title":"Psychiatr Serv"},{"key":"zoi210165r10","volume-title":"Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse","author":"Phillips","year":"2017"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2779046\/wilson_2021_oi_210165_1618442571.13093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T22:50:40Z","timestamp":1619131840000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2779046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.4552","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,22]]}}}