{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:23:41Z","timestamp":1788009821993,"version":"build-2784847793"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2021.46912","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T11:02:40Z","timestamp":1645009360000},"page":"e2146912","source":"Crossref","is-referenced-by-count":42,"title":["A Propensity Score Analysis of Chemotherapy Use in Patients With Resectable Gallbladder Cancer"],"prefix":"10.1001","volume":"5","author":[{"given":"Muhammet","family":"Ozer","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas"},{"name":"Department of Internal Medicine, Capital Health Regional Medical Center, Trenton, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman Y.","family":"Goksu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina N.","family":"Sanford","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Porembka","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajra","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Claire","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shaalan","family":"Beg","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed M.","family":"Kazmi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"issue":"2","key":"zoi211294r1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1634\/theoncologist.2009-0302","article-title":"Current management of gallbladder carcinoma.","volume":"15","author":"Zhu","year":"2010","journal-title":"Oncologist"},{"issue":"3","key":"zoi211294r2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S1470-2045(03)01021-0","article-title":"Carcinoma of the gallbladder.","volume":"4","author":"Misra","year":"2003","journal-title":"Lancet Oncol"},{"issue":"4","key":"zoi211294r3","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/00000658-200010000-00011","article-title":"Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention.","volume":"232","author":"Fong","year":"2000","journal-title":"Ann Surg"},{"issue":"12","key":"zoi211294r4","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.v127:12","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"issue":"14","key":"zoi211294r5","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1056\/NEJMoa0908721","article-title":"Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.","volume":"362","author":"Valle","year":"2010","journal-title":"N Engl J Med"},{"issue":"4","key":"zoi211294r6","article-title":"Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.","volume":"4","author":"Abdel-Rahman","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"zoi211294r7","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S1470-2045(18)30915-X","article-title":"Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.","volume":"20","author":"Primrose","year":"2019","journal-title":"Lancet Oncol"},{"issue":"9","key":"zoi211294r8","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1001\/jamaoncol.2017.0515","article-title":"Effect of neoadjuvant chemotherapy followed by surgical resection on survival in patients with limited metastatic gastric or gastroesophageal junction cancer: the AIO-FLOT3 trial.","volume":"3","author":"Al-Batran","year":"2017","journal-title":"JAMA Oncol"},{"issue":"1","key":"zoi211294r9","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1038\/s41467-020-19965-6","article-title":"Neoadjuvant FLOT versus SOX phase II randomized clinical trial for patients with locally advanced gastric cancer.","volume":"11","author":"Sah","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"zoi211294r10","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1007\/s10120-019-00941-z","article-title":"Randomized phase III trial of gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer, the short-term safety and surgical results: Japan Clinical Oncology Group Study (JCOG0501).","volume":"22","author":"Terashima","year":"2019","journal-title":"Gastric Cancer"},{"issue":"4","key":"zoi211294r11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1200\/JCO.2019.37.4_suppl.189","article-title":"Randomized phase II\/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02\/JSAP-05).","volume":"37","author":"Unno","year":"2019","journal-title":"J Clin Oncol"},{"issue":"7","key":"zoi211294r12","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1001\/jamaoncol.2019.0892","article-title":"Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: a phase 2 clinical trial.","volume":"5","author":"Murphy","year":"2019","journal-title":"JAMA Oncol"},{"issue":"9","key":"zoi211294r14","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.hpb.2018.03.008","article-title":"Outcome of neoadjuvant chemotherapy in \u201clocally advanced\/borderline resectable\u201d gallbladder cancer: the need to define indications.","volume":"20","author":"Chaudhari","year":"2018","journal-title":"HPB (Oxford)"},{"issue":"6","key":"zoi211294r15","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-028147","article-title":"A phase III randomised clinical trial of perioperative therapy (neoadjuvant chemotherapy versus chemoradiotherapy) in locally advanced gallbladder cancers (POLCAGB): study protocol.","volume":"9","author":"Engineer","year":"2019","journal-title":"BMJ Open"},{"key":"zoi211294r16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ijsu.2018.02.052","article-title":"Adjuvant systemic therapy after resection of node positive gallbladder cancer: time for a well-designed trial? (results of a US-national retrospective cohort study).","volume":"52","author":"Bergquist","year":"2018","journal-title":"Int J Surg"},{"issue":"4","key":"zoi211294r17","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.athoracsur.2017.04.065","article-title":"Survival after esophagectomy: a propensity-matched study of different surgical approaches.","volume":"104","author":"Weksler","year":"2017","journal-title":"Ann Thorac Surg"},{"issue":"8","key":"zoi211294r18","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.ejso.2019.03.023","article-title":"Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: a propensity score matched analysis.","volume":"45","author":"Yadav","year":"2019","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"zoi211294r19","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cmpb.2003.10.004","article-title":"Adjusted survival curves with inverse probability weights.","volume":"75","author":"Cole","year":"2004","journal-title":"Comput Methods Programs Biomed"},{"issue":"6","key":"zoi211294r21","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/sim.v33.6","article-title":"A comparison of 12 algorithms for matching on the propensity score.","volume":"33","author":"Austin","year":"2014","journal-title":"Stat Med"},{"issue":"3","key":"zoi211294r22","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies.","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav Res"},{"issue":"3","key":"zoi211294r23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1020363010465","article-title":"Using propensity scores to help design observational studies: application to the tobacco litigation.","volume":"2","author":"Rubin","year":"2001","journal-title":"Health Services Outcomes Res Methodology"},{"issue":"6","key":"zoi211294r24","first-page":"3125","article-title":"Gemcitabine-based adjuvant chemotherapy for patients with advanced gallbladder cancer.","volume":"34","author":"Nakamura","year":"2014","journal-title":"Anticancer Res"},{"issue":"2","key":"zoi211294r25","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejso.2018.08.020","article-title":"The role of neoadjuvant chemotherapy or chemoradiotherapy for advanced gallbladder cancer\u2014a systematic review.","volume":"45","author":"Hakeem","year":"2019","journal-title":"Eur J Surg Oncol"},{"issue":"8","key":"zoi211294r26","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/cncr.10831","article-title":"Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma.","volume":"95","author":"Takada","year":"2002","journal-title":"Cancer"},{"issue":"7","key":"zoi211294r27","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/jso.21141","article-title":"Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC).","volume":"98","author":"Duffy","year":"2008","journal-title":"J Surg Oncol"},{"issue":"1","key":"zoi211294r28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12885-020-6610-4","article-title":"Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC\/ECC): a phase III study of the German registry of incidental gallbladder carcinoma platform (GR)\u2014the AIO\/CALGP\/ACO-GAIN trial.","volume":"20","author":"Goetze","year":"2020","journal-title":"BMC Cancer"},{"issue":"11","key":"zoi211294r29","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1245\/s10434-007-9539-9","article-title":"A phase II study of gemcitabine and capecitabine in advanced cholangiocarcinoma and carcinoma of the gallbladder: a single-institution prospective study.","volume":"14","author":"Iyer","year":"2007","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"zoi211294r30","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.7314\/APJCP.2016.17.4.2137","article-title":"Radiological downstaging with neoadjuvant therapy in unresectable gall bladder cancer cases.","volume":"17","author":"Agrawal","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"issue":"2","key":"zoi211294r31","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s13304-019-00670-z","article-title":"Selecting treatment sequence for patients with incidental gallbladder cancer: a neoadjuvant approach versus upfront surgery.","volume":"71","author":"Cherkassky","year":"2019","journal-title":"Updates Surg"},{"issue":"1","key":"zoi211294r32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.6004\/jnccn.2017.7067","article-title":"Chemoradiotherapy versus chemotherapy alone for unresected nonmetastatic gallbladder cancer: national practice patterns and outcomes.","volume":"16","author":"Verma","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"issue":"3","key":"zoi211294r33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/000313489906500312","article-title":"Preoperative chemoradiotherapy in the treatment of gallbladder cancer.","volume":"65","author":"de Aretxabala","year":"1999","journal-title":"Am Surg"},{"issue":"5","key":"zoi211294r34","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.jamcollsurg.2016.12.058","article-title":"Systemic chemotherapy combined with resection for locally advanced gallbladder carcinoma: surgical and survival outcomes.","volume":"224","author":"Creasy","year":"2017","journal-title":"J Am Coll Surg"},{"issue":"10","key":"zoi211294r35","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.2217\/fon.14.308","article-title":"Neoadjuvant chemotherapy in patients with locally advanced gallbladder cancer.","volume":"11","author":"Sirohi","year":"2015","journal-title":"Future Oncol"},{"issue":"9","key":"zoi211294r36","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1245\/s10434-016-5197-0","article-title":"Neoadjuvant chemoradiation followed by surgery for locally advanced gallbladder cancers: a new paradigm.","volume":"23","author":"Engineer","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"zoi211294r37","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s13193-015-0377-0","article-title":"Resection after neoadjuvant chemotherapy in advanced carcinoma of the gallbladder: a retrospective study.","volume":"6","author":"Selvakumar","year":"2015","journal-title":"Indian J Surg Oncol"},{"issue":"4","key":"zoi211294r38","doi-asserted-by":"publisher","first-page":"652","DOI":"10.21037\/jgo","article-title":"Molecular profiling of biliary cancers reveals distinct molecular alterations and potential therapeutic targets.","volume":"10","author":"Weinberg","year":"2019","journal-title":"J Gastrointest Oncol"},{"key":"zoi211294r13","unstructured":"American College of Surgeons. National Cancer Database. Accessed January 5, 2020. https:\/\/www.facs.org\/quality-programs\/cancer\/ncdb"},{"key":"zoi211294r20","doi-asserted-by":"crossref","unstructured":"Ho D, Imai K, King G, Stuart E. MatchIt: nonparametric preprocessing for parametric causal inference. 2011. Accessed January 15, 2020. https:\/\/gking.harvard.edu\/matchit","DOI":"10.18637\/jss.v042.i08"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2789085\/ozer_2022_oi_211294_1644419523.8347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T23:00:20Z","timestamp":1674774020000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2789085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.46912","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]}}}