{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:07:57Z","timestamp":1791958077817,"version":"4.3.4"},"reference-count":64,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2021.8782","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T15:01:27Z","timestamp":1621350087000},"page":"e218782","source":"Crossref","is-referenced-by-count":43,"title":["Association of Opioid Consumption Profiles After Hospitalization With Risk of Adverse Health Care Events"],"prefix":"10.1001","volume":"4","author":[{"given":"Siyana","family":"Kurteva","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada"},{"name":"Clinical and Health Informatics Research Group, Department of Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Abrahamowicz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Gomes","sequence":"additional","affiliation":[{"name":"Institute of Health Policy Management and Evaluation, Toronto, Ontario, Canada"},{"name":"Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada"},{"name":"ICES, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Tamblyn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada"},{"name":"Clinical and Health Informatics Research Group, Department of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"ICES, Toronto, Ontario, Canada"},{"name":"McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"issue":"2","key":"zoi210279r1","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.17269\/cjph.105.4143","article-title":"Non-medical prescription opioid use, prescription opioid-related harms and public health in Canada: an update 5 years later.","volume":"105","author":"Fischer","year":"2014","journal-title":"Can J Public Health"},{"issue":"7","key":"zoi210279r2","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1001\/archinternmed.2011.117","article-title":"Opioid dose and drug-related mortality in patients with nonmalignant pain.","volume":"171","author":"Gomes","year":"2011","journal-title":"Arch Intern Med"},{"key":"zoi210279r4","doi-asserted-by":"publisher","first-page":"d5142","DOI":"10.1136\/bmj.d5142","article-title":"Facing up to the prescription opioid crisis.","volume":"343","author":"Dhalla","year":"2011","journal-title":"BMJ"},{"issue":"2","key":"zoi210279r5","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1136\/rapm-2018-000040","article-title":"Risk factors for severe acute pain and persistent pain after surgery for breast cancer: a prospective observational study.","volume":"44","author":"Habib","year":"2019","journal-title":"Reg Anesth Pain Med"},{"key":"zoi210279r6","doi-asserted-by":"crossref","DOI":"10.1136\/rapm-2018-100036","article-title":"Acute postoperative pain is an independent predictor of chronic postsurgical pain following total knee arthroplasty at 6 months: a prospective cohort study.","author":"Buvanendran","year":"2019","journal-title":"Reg Anesth Pain Med"},{"issue":"22","key":"zoi210279r7","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1056\/NEJMp1402780","article-title":"Medication-assisted therapies\u2014tackling the opioid-overdose epidemic.","volume":"370","author":"Volkow","year":"2014","journal-title":"N Engl J Med"},{"issue":"4","key":"zoi210279r8","first-page":"e217","article-title":"Medication-related emergency department visits and hospitalizations among older adults.","volume":"60","author":"Bayoumi","year":"2014","journal-title":"Can Fam Physician"},{"issue":"2","key":"zoi210279r9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.12927\/hcq","article-title":"Types of opioid harms in Canadian hospitals: comparing Canada and Australia.","volume":"22","author":"Frood","year":"2019","journal-title":"Healthc Q"},{"issue":"5","key":"zoi210279r10","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s11606-015-3539-4","article-title":"Opioid prescribing at hospital discharge contributes to chronic opioid use.","volume":"31","author":"Calcaterra","year":"2016","journal-title":"J Gen Intern Med"},{"issue":"18","key":"zoi210279r11","doi-asserted-by":"publisher","first-page":"E659","DOI":"10.1503\/cmaj.170363","article-title":"Guideline for opioid therapy and chronic noncancer pain.","volume":"189","author":"Busse","year":"2017","journal-title":"CMAJ"},{"key":"zoi210279r12","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD012509","article-title":"Adverse events associated with medium- and long-term use of opioids for chronic non-cancer pain: an overview of Cochrane Reviews.","volume":"10","author":"Els","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"zoi210279r13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11606-016-3810-3","article-title":"Association between initial opioid prescribing patterns and subsequent long-term use among opioid-na\u00efve patients: a statewide retrospective cohort study.","volume":"32","author":"Deyo","year":"2017","journal-title":"J Gen Intern Med"},{"issue":"11","key":"zoi210279r14","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.jpain.2017.06.010","article-title":"Factors influencing long-term opioid use among opioid naive patients: an examination of initial prescription characteristics and pain etiologies.","volume":"18","author":"Shah","year":"2017","journal-title":"J Pain"},{"issue":"1","key":"zoi210279r15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.japh.2018.09.005","article-title":"Associations between initial opioid exposure and the likelihood for long-term use.","volume":"59","author":"Hadlandsmyth","year":"2019","journal-title":"J Am Pharm Assoc (2003)"},{"key":"zoi210279r16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/1745-6215-13-150","article-title":"Using novel Canadian resources to improve medication reconciliation at discharge: study protocol for a randomized controlled trial.","volume":"13","author":"Tamblyn","year":"2012","journal-title":"Trials"},{"issue":"4","key":"zoi210279r17","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"issue":"9","key":"zoi210279r18","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.10756","article-title":"Effect of an electronic medication reconciliation intervention on adverse drug events: a cluster randomized trial.","volume":"2","author":"Tamblyn","year":"2019","journal-title":"JAMA Netw Open"},{"key":"zoi210279r19","first-page":"IS26","article-title":"[Two-year follow-up of an opioid-user cohort treated with high-dose buprenorphine (Subutex)].","volume":"152","author":"Fhima","year":"2001","journal-title":"Ann Med Interne (Paris)"},{"issue":"7","key":"zoi210279r20","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1177\/0269216311398300","article-title":"Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses.","volume":"25","author":"Svendsen","year":"2011","journal-title":"Palliat Med"},{"issue":"11","key":"zoi210279r22","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.jpain.2010.02.007","article-title":"Importance of side effects in opioid treatment: a trade-off analysis with patients and physicians.","volume":"11","author":"Gregorian","year":"2010","journal-title":"J Pain"},{"issue":"3","key":"zoi210279r23","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.pain.2004.09.019","article-title":"Opioids in chronic non-cancer pain: systematic review of efficacy and safety.","volume":"112","author":"Kalso","year":"2004","journal-title":"Pain"},{"issue":"2","key":"zoi210279r24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.36076\/ppj","article-title":"A systematic review of randomized trials of long-term opioid management for chronic non-cancer pain.","volume":"14","author":"Manchikanti","year":"2011","journal-title":"Pain Physician"},{"key":"zoi210279r25","doi-asserted-by":"crossref","DOI":"10.1097\/ANA.0000000000000667","article-title":"Postoperative nausea and vomiting after craniotomy: an evidence-based review of general considerations, risk factors, and management.","author":"Uribe","year":"2019","journal-title":"J Neurosurg Anesthesiol"},{"issue":"2","key":"zoi210279r26","article-title":"Influence of opioid-related side effects on disability, mood, and opioid misuse risk among patients with chronic pain in primary care.","volume":"2","author":"Jamison","year":"2017","journal-title":"Pain Rep"},{"issue":"9","key":"zoi210279r27","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1111\/j.1532-5415.2010.03015.x","article-title":"Risk of injury associated with opioid use in older adults.","volume":"58","author":"Buckeridge","year":"2010","journal-title":"J Am Geriatr Soc"},{"key":"zoi210279r28","doi-asserted-by":"publisher","first-page":"ii37","DOI":"10.1093\/ageing\/afl084","article-title":"Falls in older people: epidemiology, risk factors and strategies for prevention.","volume":"35","author":"Rubenstein","year":"2006","journal-title":"Age Ageing"},{"issue":"5","key":"zoi210279r29","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.mcna.2006.05.013","article-title":"Falls and their prevention in elderly people: what does the evidence show?","volume":"90","author":"Rubenstein","year":"2006","journal-title":"Med Clin North Am"},{"key":"zoi210279r30","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2147\/TCRM","article-title":"The unsolved case of \u201cbone-impairing analgesics\u201d: the endocrine effects of opioids on bone metabolism.","volume":"11","author":"Coluzzi","year":"2015","journal-title":"Ther Clin Risk Manag"},{"issue":"1","key":"zoi210279r31","doi-asserted-by":"crossref","DOI":"10.2196\/publichealth.9282","article-title":"Why clinicians don\u2019t report adverse drug events: qualitative study.","volume":"4","author":"Hohl","year":"2018","journal-title":"JMIR Public Health Surveill"},{"issue":"15","key":"zoi210279r32","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1001\/jama.2016.1464","article-title":"CDC guideline for prescribing opioids for chronic pain\u2014United States, 2016.","volume":"315","author":"Dowell","year":"2016","journal-title":"JAMA"},{"key":"zoi210279r33","doi-asserted-by":"publisher","first-page":"h4725","DOI":"10.1136\/bmj.h4725","article-title":"Canada\u2019s prescription opioid epidemic grows despite tamperproof pills.","volume":"351","author":"Dyer","year":"2015","journal-title":"BMJ"},{"issue":"2","key":"zoi210279r34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jpain.2015.12.008","article-title":"Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists\u2019 Committee on Regional Anesthesia, Executive Committee, and Administrative Council.","volume":"17","author":"Chou","year":"2016","journal-title":"J Pain"},{"issue":"5","key":"zoi210279r35","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/00001648-200009000-00012","article-title":"Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.","volume":"11","author":"Hern\u00e1n","year":"2000","journal-title":"Epidemiology"},{"issue":"2","key":"zoi210279r36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2202\/1557-4679.1208","article-title":"Accuracy of conventional and marginal structural Cox model estimators: a simulation study.","volume":"6","author":"Xiao","year":"2010","journal-title":"Int J Biostat"},{"issue":"11-12","key":"zoi210279r37","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/sim.4343","article-title":"Comparison of alternative models for linking drug exposure with adverse effects.","volume":"31","author":"Abrahamowicz","year":"2012","journal-title":"Stat Med"},{"issue":"5","key":"zoi210279r38","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/aje\/kwi216","article-title":"Marginal structural models for estimating the effect of highly active antiretroviral therapy initiation on CD4 cell count.","volume":"162","author":"Cole","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"6","key":"zoi210279r39","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1093\/aje\/kwn164","article-title":"Constructing inverse probability weights for marginal structural models.","volume":"168","author":"Cole","year":"2008","journal-title":"Am J Epidemiol"},{"issue":"1","key":"zoi210279r40","doi-asserted-by":"publisher","first-page":"1-20","DOI":"10.1515\/em-2012-0006","article-title":"Comparison of approaches to weight truncation for marginal structural Cox models.","volume":"2","author":"Xiao","year":"2013","journal-title":"Epidemiol Methods"},{"issue":"5","key":"zoi210279r41","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/00001648-200009000-00011","article-title":"Marginal structural models and causal inference in epidemiology.","volume":"11","author":"Robins","year":"2000","journal-title":"Epidemiology"},{"issue":"6","key":"zoi210279r42","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1093\/ije\/25.6.1107","article-title":"Basic methods for sensitivity analysis of biases.","volume":"25","author":"Greenland","year":"1996","journal-title":"Int J Epidemiol"},{"issue":"2","key":"zoi210279r43","doi-asserted-by":"publisher","first-page":"102","DOI":"10.7326\/0003-4819-141-2-200407200-00008","article-title":"Mortality rates in elderly patients who take different angiotensin-converting enzyme inhibitors after acute myocardial infarction: a class effect?","volume":"141","author":"Pilote","year":"2004","journal-title":"Ann Intern Med"},{"issue":"10180","key":"zoi210279r45","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/S0140-6736(19)30352-6","article-title":"Transition from acute to chronic pain after surgery.","volume":"393","author":"Glare","year":"2019","journal-title":"Lancet"},{"issue":"10180","key":"zoi210279r46","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/S0140-6736(19)30428-3","article-title":"Inappropriate opioid prescription after surgery.","volume":"393","author":"Neuman","year":"2019","journal-title":"Lancet"},{"issue":"23","key":"zoi210279r47","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1001\/jama.2018.18472","article-title":"Opioids for chronic noncancer pain: a systematic review and meta-analysis.","volume":"320","author":"Busse","year":"2018","journal-title":"JAMA"},{"issue":"1","key":"zoi210279r48","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/00045391-200401000-00008","article-title":"Patient characteristics and risks factors for development of dependence on hydrocodone and oxycodone.","volume":"11","author":"Miller","year":"2004","journal-title":"Am J Ther"},{"issue":"2","key":"zoi210279r49","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S1072-7515(02)01800-8","article-title":"The importance of opioid tolerance: a therapeutic paradox.","volume":"196","author":"Thompson","year":"2003","journal-title":"J Am Coll Surg"},{"issue":"4","key":"zoi210279r50","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s11606-009-1218-z","article-title":"Relationship of opioid use and dosage levels to fractures in older chronic pain patients.","volume":"25","author":"Saunders","year":"2010","journal-title":"J Gen Intern Med"},{"issue":"9","key":"zoi210279r51","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1111\/add.2014.109.issue-9","article-title":"The burden of premature opioid-related mortality.","volume":"109","author":"Gomes","year":"2014","journal-title":"Addiction"},{"issue":"13","key":"zoi210279r52","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1001\/jama.2011.370","article-title":"Association between opioid prescribing patterns and opioid overdose-related deaths.","volume":"305","author":"Bohnert","year":"2011","journal-title":"JAMA"},{"issue":"3","key":"zoi210279r53","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1001\/2013.jamainternmed.733","article-title":"Opioid dose and risk of road trauma in Canada: a population-based study.","volume":"173","author":"Gomes","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"5","key":"zoi210279r54","doi-asserted-by":"publisher","first-page":"746","DOI":"10.2215\/CJN.09910917","article-title":"Opioid analgesics and adverse outcomes among hemodialysis patients.","volume":"13","author":"Ishida","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"zoi210279r55","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.drugalcdep.2005.08.019","article-title":"Association between non-medical and prescriptive usage of opioids.","volume":"82","author":"Dasgupta","year":"2006","journal-title":"Drug Alcohol Depend"},{"issue":"8","key":"zoi210279r56","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s40264-018-0660-4","article-title":"Comparative rates of mortality and serious adverse effects among commonly prescribed opioid analgesics.","volume":"41","author":"Murphy","year":"2018","journal-title":"Drug Saf"},{"issue":"13","key":"zoi210279r58","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1001\/jama.2011.401","article-title":"Characteristics of opioid prescriptions in 2009.","volume":"305","author":"Volkow","year":"2011","journal-title":"JAMA"},{"issue":"2","key":"zoi210279r59","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/jhm.v9.2","article-title":"Prevalence and characteristics of hospitalized adults on chronic opioid therapy.","volume":"9","author":"Mosher","year":"2014","journal-title":"J Hosp Med"},{"issue":"4","key":"zoi210279r60","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1001\/jamainternmed.2014.8071","article-title":"Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy.","volume":"175","author":"Miller","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"2","key":"zoi210279r61","doi-asserted-by":"publisher","first-page":"131","DOI":"10.5055\/jom.2018.0440","article-title":"Long-term opioid users with chronic noncancer pain: assessment of opioid abuse risk and relationship with healthcare resource use.","volume":"14","author":"Coutinho","year":"2018","journal-title":"J Opioid Manag"},{"issue":"1","key":"zoi210279r62","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12916-018-1058-y","article-title":"Healthcare costs and utilization associated with high-risk prescription opioid use: a retrospective cohort study.","volume":"16","author":"Chang","year":"2018","journal-title":"BMC Med"},{"issue":"2","key":"zoi210279r63","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/jgs.2005.53.issue-2","article-title":"A 5-year prospective assessment of the risk associated with individual benzodiazepines and doses in new elderly users.","volume":"53","author":"Tamblyn","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"zoi210279r3","unstructured":"World Health Organization. WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents. Accessed March 30, 2020. https:\/\/apps.who.int\/iris\/handle\/10665\/279700"},{"key":"zoi210279r21","unstructured":"Vigilance Sant\u00e9. Drugs database and pharmaceutical software for health professionals and pharmacists. Accessed November 30, 2020. https:\/\/www.vigilance.ca"},{"key":"zoi210279r44","unstructured":"Centers for Medicare & Medicaid Services. Opioid oral morphine milligram equivalent (MME) conversion factors. Accessed September 5, 2019. https:\/\/www.cms.gov\/Medicare\/Prescription-Drug-Coverage\/PrescriptionDrugCovContra\/Downloads\/Oral-MME-CFs-vFeb-2018.pdf"},{"key":"zoi210279r57","unstructured":"Centers for Disease Control and Prevention, National Center for Health Statistics. Number and age-adjusted rates of drug-poisoning deaths involving opioid analgesics and heroin: United States, 2000\u20132014. National Vital Statistics System, Mortality File. Accessed March 20, 2020. https:\/\/www.cdc.gov\/nchs\/data\/health_policy\/AADR_drug_poisoning_involving_OA_Heroin_US_2000-2014. pdf"},{"key":"zoi210279r64","unstructured":"Fuller? C. The Association Between Non-Concordance with the Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain and Opioid Overdose Death in Quebec. Thesis. McGill University; 2015. Accessed November 10, 2020. https:\/\/escholarship.mcgill.ca\/concern\/theses\/j6731696b"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2779938\/kurteva_2021_oi_210279_1620356548.72158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T15:01:38Z","timestamp":1621350098000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2779938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.8782","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]}}}