{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:21:50Z","timestamp":1788348110001,"version":"build-2803163510"},"reference-count":40,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Although contact isolation has been widely recommended for multidrug-resistant organisms, contact isolation has raised some concerns that it may bring unintended patient harms.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To compare adverse events between a contact isolation group with vancomycin-resistant\n Enterococcus<\/jats:italic>\n (VRE) and a matched comparison group using a relatively large data set from full electronic medical records (EMR) and propensity score\u2013matching methods.\n <\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This retrospective, matched cohort study was conducted at Seoul National University Bundang Hospital (SNUBH) in Korea, a tertiary, university-affiliated hospital that has 1337 inpatient beds. Participants included a total of 98\u202f529 hospitalized adult patients (aged \u226518 years) during 2015 to 2017.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Contact isolation in a single or shared double room.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n As adverse contact isolation\u2013related outcomes, falls and pressure ulcers were included. All relevant EMR data were extracted from the SNUBH clinical data warehouse. Risk factors for adverse events were included in the propensity score model based on literature reviews, such as Braden scale score and Hendrich II fall risk score. A fine stratification and weighting (FSW) and a 1:10 nearest neighbor (NN) propensity score matching as a sensitivity analysis were adopted to compare adverse events between the 2 groups for the observation period from the study entry date and the exit date. Time-to-event analyses with a Cox proportional hazard model were conducted in December 2021.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n For comparison of outcomes in wards, 177 patients (mean [SD] age, 67.38 [14.12] years; 98 [55.4%] female) with VRE and 93\u202f022 patients (mean [SD] age, 56.44 [16.88] years; 49\u202f462 [53.2%] female) without VRE were included and no difference was found in basic characteristics from the FSW (VRE contact isolation [n\u2009=\u2009172] vs comparison [n\u2009=\u200969\u202f434]) as well as from the 1:10 NN (VRE contact isolation [n\u2009=\u2009168] vs comparison [n\u2009=\u20091650]). Among 177 patients with VRE contact isolation, 8 pressure ulcers and 3 falls occurred during their hospital stays; incidence rates of adverse events were 2.5 and 0.9 per 1000 patient-days, respectively (pressure ulcer incidence rate from the FSW: 2.53 per 1000 patient-days [95% CI, 1.09-4.99 per 1000 patient-days]; pressure ulcer incidence rate from the 1:10 NN: 2.54 per 1000 patient-days [95% CI, 1.10-5.01 per 1000 patient-days]; fall incidence rate from the FSW: 0.87 per 1000 patient-days [95% CI, 0.18-2.54 per 1000 patient-days]; fall incidence rate from the 1:10 NN: 0.87 per 1000 patient-days [95% CI, 0.18-2.55 per 1000 patient-days]). The hazard ratios for adverse events showed no statistically significant differences for both groups: 1.42 (95% CI, 0.67-2.99) for pressure ulcer and 0.66 (95% CI, 0.20-2.13) for fall from the FSW.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study, no association was found between the likelihood of adverse events and contact isolation using propensity score\u2013matching methods and closely related covariates for adverse events.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2022.1865","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T11:03:41Z","timestamp":1646910221000},"page":"e221865","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Patients\u2019 Adverse Events During Contact Isolation for Vancomycin-Resistant\n Enterococci<\/i>\n Using a Matched Cohort Study With Propensity Score"],"prefix":"10.1001","volume":"5","author":[{"given":"JaHyun","family":"Kang","sequence":"first","affiliation":[{"name":"College of Nursing, Seoul National University, Seoul, Korea"},{"name":"Research Institute of Nursing Science, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjeong","family":"Ji","sequence":"additional","affiliation":[{"name":"Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunok","family":"Bae","sequence":"additional","affiliation":[{"name":"Office of Digital Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Office of Digital Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eu Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"},{"name":"Center for Infection Control, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Center for Infection Control, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"issue":"8","key":"zoi220082r2","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1086\/666629","article-title":"Resource burden associated with contact precautions for methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus: the patient access managers\u2019 perspective.","volume":"33","author":"Shenoy","year":"2012","journal-title":"Infect Control Hosp 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