{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:58:42Z","timestamp":1792263522653,"version":"4.4.0"},"reference-count":46,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2022.25647","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T15:02:12Z","timestamp":1659970932000},"page":"e2225647","source":"Crossref","is-referenced-by-count":11,"title":["Association of Single-Nucleotide Variants in the Human Leukocyte Antigen and Other Loci With Childhood Hodgkin Lymphoma"],"prefix":"10.1001","volume":"5","author":[{"given":"Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiaotong University, Shanghai, China"},{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"},{"name":"College of Pharmacy, Chungbuk National University, Cheongju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Easton","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"},{"name":"Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie L.","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"},{"name":"Department of Computational Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"issue":"1","key":"zoi220724r1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nrc2542","article-title":"The biology of Hodgkin\u2019s lymphoma.","volume":"9","author":"K\u00fcppers","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"zoi220724r2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41572-020-0189-6","article-title":"Hodgkin lymphoma.","volume":"6","author":"Connors","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"zoi220724r4","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1093\/jnci\/djaa147","article-title":"Epigenetic age acceleration and chronic health conditions among adult survivors of childhood cancer.","volume":"113","author":"Qin","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"13","key":"zoi220724r5","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1200\/JCO.2001.19.13.3163","article-title":"Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study.","volume":"19","author":"Mertens","year":"2001","journal-title":"J Clin Oncol"},{"issue":"6","key":"zoi220724r6","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1182\/blood-2010-04-278796","article-title":"Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study.","volume":"117","author":"Castellino","year":"2011","journal-title":"Blood"},{"key":"zoi220724r7","doi-asserted-by":"publisher","first-page":"10045","DOI":"10.1200\/JCO.2021.39.15_suppl.10045","article-title":"Accelerated aging and mortality in long-term survivors of childhood cancer: a report from the St. Jude Lifetime Cohort (SJLIFE).","volume":"39","author":"Williams","year":"2021","journal-title":"J Clin Oncol"},{"issue":"7","key":"zoi220724r9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1056\/NEJM199502163320701","article-title":"Concordance for Hodgkin\u2019s disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease.","volume":"332","author":"Mack","year":"1995","journal-title":"N Engl J Med"},{"issue":"11","key":"zoi220724r10","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1136\/jcp.56.11.811","article-title":"The Scotland and Newcastle epidemiological study of Hodgkin\u2019s disease: impact of histopathological review and EBV status on incidence estimates.","volume":"56","author":"Jarrett","year":"2003","journal-title":"J Clin Pathol"},{"key":"zoi220724r11","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/genom.2013.14.issue-1","article-title":"Major histocompatibility complex genomics and human disease.","volume":"14","author":"Trowsdale","year":"2013","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"6","key":"zoi220724r12","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.smim.2008.06.003","article-title":"The yin and yang of HLA and KIR in human disease.","volume":"20","author":"Kulkarni","year":"2008","journal-title":"Semin Immunol"},{"issue":"3","key":"zoi220724r14","first-page":"497","article-title":"Localization of predisposition to Hodgkin disease in the HLA class II region.","volume":"54","author":"Klitz","year":"1994","journal-title":"Am J Hum Genet"},{"issue":"19","key":"zoi220724r15","first-page":"5101","article-title":"A clinical and epidemiological study of human leukocyte antigen-DPB alleles in Hodgkin\u2019s disease.","volume":"54","author":"Oza","year":"1994","journal-title":"Cancer Res"},{"issue":"4","key":"zoi220724r16","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/(ISSN)1097-0215","article-title":"HLA in familial Hodgkin\u2019s disease: results and a new hypothesis.","volume":"19","author":"Marshall","year":"1977","journal-title":"Int J Cancer"},{"issue":"3","key":"zoi220724r17","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1182\/blood-2011-03-339630","article-title":"Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3.","volume":"118","author":"Moutsianas","year":"2011","journal-title":"Blood"},{"issue":"1","key":"zoi220724r18","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1038\/s41467-017-00320-1","article-title":"Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.","volume":"8","author":"Sud","year":"2017","journal-title":"Nat Commun"},{"issue":"12","key":"zoi220724r19","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ng.696","article-title":"A genome-wide association study of Hodgkin\u2019s lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).","volume":"42","author":"Enciso-Mora","year":"2010","journal-title":"Nat Genet"},{"issue":"9","key":"zoi220724r20","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1001\/jamaoncol.2019.2203","article-title":"Association of germline BRCA2 mutations with the risk of pediatric or adolescent non-Hodgkin lymphoma.","volume":"5","author":"Wang","year":"2019","journal-title":"JAMA Oncol"},{"issue":"1","key":"zoi220724r21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/ije\/dyaa203","article-title":"Cohort profile: The St. Jude Lifetime Cohort Study (SJLIFE) for paediatric cancer survivors.","volume":"50","author":"Howell","year":"2021","journal-title":"Int J Epidemiol"},{"issue":"5","key":"zoi220724r22","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1158\/1055-9965.EPI-16-0812","article-title":"Approach for classification and severity grading of long-term and late-onset health events among childhood cancer survivors in the St. Jude Lifetime Cohort.","volume":"26","author":"Hudson","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"14","key":"zoi220724r23","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1200\/JCO.2009.22.3339","article-title":"The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research.","volume":"27","author":"Robison","year":"2009","journal-title":"J Clin Oncol"},{"issue":"24","key":"zoi220724r24","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1200\/JCO.19.02760","article-title":"Pathogenic germline mutations in DNA repair genes in combination with cancer treatment exposures and risk of subsequent neoplasms among long-term survivors of childhood cancer.","volume":"38","author":"Qin","year":"2020","journal-title":"J Clin Oncol"},{"issue":"20","key":"zoi220724r25","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1200\/JCO.2018.77.8589","article-title":"Genetic risk for subsequent neoplasms among long-term survivors of childhood cancer.","volume":"36","author":"Wang","year":"2018","journal-title":"J Clin Oncol"},{"issue":"3","key":"zoi220724r27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"18","key":"zoi220724r28","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: regional visualization of genome-wide association scan results.","volume":"26","author":"Pruim","year":"2010","journal-title":"Bioinformatics"},{"issue":"2","key":"zoi220724r29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1182\/blood-2011-03-343921","article-title":"A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32.","volume":"119","author":"Cozen","year":"2012","journal-title":"Blood"},{"issue":"3","key":"zoi220724r30","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/jnci\/djr516","article-title":"Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.","volume":"104","author":"Urayama","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"zoi220724r31","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1038\/sj.bjc.6690536","article-title":"Further investigation of the role of HLA-DPB1 in adult Hodgkin\u2019s disease (HD) suggests an influence on susceptibility to different HD subtypes.","volume":"80","author":"Taylor","year":"1999","journal-title":"Br J Cancer"},{"issue":"1","key":"zoi220724r32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1182\/blood.V87.1.25.25","article-title":"REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma.","volume":"87","author":"Houldsworth","year":"1996","journal-title":"Blood"},{"issue":"9","key":"zoi220724r33","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1182\/blood-2002-08-2577","article-title":"Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.","volume":"101","author":"Barth","year":"2003","journal-title":"Blood"},{"issue":"10","key":"zoi220724r34","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1182\/blood-2003-11-4026","article-title":"Deregulated expression in Ph+ human leukemias of AHI-1, a gene activated by insertional mutagenesis in mouse models of leukemia.","volume":"103","author":"Jiang","year":"2004","journal-title":"Blood"},{"issue":"1","key":"zoi220724r35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/10245330400020405","article-title":"The platelet-derived growth factor level (PDGF) in Hodgkin\u2019s disease and non-Hodgkin\u2019s lymphoma and its relationship disease activation.","volume":"10","author":"G\u00fcler","year":"2005","journal-title":"Hematology"},{"issue":"7","key":"zoi220724r36","first-page":"B4485","article-title":"On the aetiology of Hodgkin lymphoma.","volume":"59","author":"Hjalgrim","year":"2012","journal-title":"Dan Med J"},{"issue":"12","key":"zoi220724r37","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1158\/1055-9965.EPI-15-0534","article-title":"A novel risk locus at 6p21.3 for Epstein-Barr virus-positive Hodgkin lymphoma.","volume":"24","author":"Delahaye-Sourdeix","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"zoi220724r38","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1038\/ncomms3549","article-title":"Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin\u2019s lymphoma.","volume":"4","author":"Frampton","year":"2013","journal-title":"Nat Commun"},{"key":"zoi220724r39","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.1038\/ncomms4856","article-title":"A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.","volume":"5","author":"Cozen","year":"2014","journal-title":"Nat Commun"},{"issue":"19","key":"zoi220724r40","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1182\/blood-2018-06-855296","article-title":"Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.","volume":"132","author":"Sud","year":"2018","journal-title":"Blood"},{"issue":"1","key":"zoi220724r41","first-page":"122","article-title":"Emerging roles of PDGF-D signaling pathway in tumor development and progression.","volume":"1806","author":"Wang","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"zoi220724r42","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1091\/mbc.3.10.1131","article-title":"Induction of NF-kappa B-like activity by platelet-derived growth factor in mouse fibroblasts.","volume":"3","author":"Olashaw","year":"1992","journal-title":"Mol Biol Cell"},{"issue":"4","key":"zoi220724r43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T","article-title":"Epstein-Barr virus-associated Hodgkin\u2019s disease: epidemiologic characteristics in international data.","volume":"70","author":"Glaser","year":"1997","journal-title":"Int J Cancer"},{"issue":"1732","key":"zoi220724r44","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0271","article-title":"Epstein-Barr virus-associated lymphomas.","volume":"372","author":"Shannon-Lowe","year":"2017","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"9478","key":"zoi220724r45","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/S0140-6736(05)66780-3","article-title":"Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin\u2019s lymphoma.","volume":"365","author":"Diepstra","year":"2005","journal-title":"Lancet"},{"issue":"11","key":"zoi220724r46","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1158\/1055-9965.EPI-06-0476","article-title":"The human leukocyte antigen class I region is associated with EBV-positive Hodgkin\u2019s lymphoma: HLA-A and HLA complex group 9 are putative candidate genes.","volume":"15","author":"Niens","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"zoi220724r8","author":"Campo","year":"2008"},{"key":"zoi220724r13","author":"Amiel","year":"1967"},{"key":"zoi220724r3","unstructured":"Cancer Stat Facts. Hodgkin lymphoma. Accessed July 7, 2022. https:\/\/seer.cancer.gov\/statfacts\/html\/hodg.html"},{"key":"zoi220724r26","unstructured":"St Jude Children\u2019s Research Hospital. St Jude Cloud. Accessed July 8, 2022. https:\/\/www.stjude.cloud\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2794974\/chen_2022_oi_220724_1659114233.32113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T15:02:24Z","timestamp":1659970944000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2794974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.25647","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]}}}