{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:02:39Z","timestamp":1789095759454,"version":"build-2803163510"},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"DOI":"10.1001\/jamanetworkopen.2022.29333","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T15:33:05Z","timestamp":1661959985000},"page":"e2229333","source":"Crossref","is-referenced-by-count":7,"title":["Risk Levels and Adverse Clinical Outcomes Among Patients With Nonvalvular Atrial Fibrillation Receiving Oral Anticoagulants"],"prefix":"10.1001","volume":"5","author":[{"given":"Gregory Y. H.","family":"Lip","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom"},{"name":"Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Federal Aviation Administration, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Sahiar","sequence":"additional","affiliation":[{"name":"Federal Aviation Administration, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Ingall","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Scottsdale, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol D.","family":"Dhamane","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Lawrenceville, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Ferri","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Lawrenceville, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hlavacek","sequence":"additional","affiliation":[{"name":"Pfizer, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison T.","family":"Preib","sequence":"additional","affiliation":[{"name":"STATinMED Research, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Keshishian","sequence":"additional","affiliation":[{"name":"STATinMED Research, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Russ","sequence":"additional","affiliation":[{"name":"Pfizer, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Lawrenceville, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Yuce","sequence":"additional","affiliation":[{"name":"Pfizer, New York, New York"},{"name":"New York City College of Technology, City University of New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Deitelzweig","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Ochsner Clinic Foundation, New Orleans, Louisiana"},{"name":"Ochsner Clinical School, University of Queensland School of Medicine, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"issue":"8","key":"zoi220834r1","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.amjcard.2013.05.063","article-title":"Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population.","volume":"112","author":"Colilla","year":"2013","journal-title":"Am J Cardiol"},{"issue":"1","key":"zoi220834r2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1161\/CIRCRESAHA.120.316340","article-title":"Epidemiology of atrial fibrillation in the 21st century: novel methods and new insights.","volume":"127","author":"Kornej","year":"2020","journal-title":"Circ Res"},{"issue":"9989","key":"zoi220834r3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0140-6736(14)61774-8","article-title":"50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study.","volume":"386","author":"Schnabel","year":"2015","journal-title":"Lancet"},{"issue":"8","key":"zoi220834r4","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"issue":"9","key":"zoi220834r5","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.18632\/aging.v11i9","article-title":"Aging and ischemic stroke.","volume":"11","author":"Yousufuddin","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"zoi220834r6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/1753944712464101","article-title":"Burden of comorbidities among patients with atrial fibrillation.","volume":"7","author":"LaMori","year":"2013","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"8","key":"zoi220834r7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181766","article-title":"Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy.","volume":"12","author":"Callizo","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"zoi220834r8","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1161\/01.STR.0000158917.59233.b7","article-title":"Incidence and short-term prognosis of transient ischemic attack in a population-based study.","volume":"36","author":"Kleindorfer","year":"2005","journal-title":"Stroke"},{"issue":"2","key":"zoi220834r9","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd6020019","article-title":"Cardiovascular risks associated with gender and aging.","volume":"6","author":"Rodgers","year":"2019","journal-title":"J Cardiovasc Dev Dis"},{"issue":"10266","key":"zoi220834r10","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/S0140-6736(20)31559-2","article-title":"Retinal vascular occlusions.","volume":"396","author":"Scott","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"zoi220834r11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on Atrial Fibrillation.","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"issue":"1","key":"zoi220834r12","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jacc.2019.01.011","article-title":"2019 AHA\/ACC\/HRS focused update of the 2014 AHA\/ACC\/HRS Guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.","volume":"74","author":"January","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"zoi220834r13","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.chest.2018.07.040","article-title":"Antithrombotic therapy for atrial fibrillation: CHEST guideline and expert panel report.","volume":"154","author":"Lip","year":"2018","journal-title":"Chest"},{"issue":"1","key":"zoi220834r14","first-page":"783","article-title":"Age as a risk factor for stroke in atrial fibrillation patients: implications in thromboprophylaxis in the era of novel oral anticoagulants.","volume":"6","author":"Mitrousi","year":"2013","journal-title":"J Atr Fibrillation"},{"key":"zoi220834r15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3389\/fmed.2019.00175","article-title":"Atrial fibrillation in older people: concepts and controversies.","volume":"6","author":"Zathar","year":"2019","journal-title":"Front Med (Lausanne)"},{"issue":"12","key":"zoi220834r16","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1161\/STROKEAHA.118.020232","article-title":"Effectiveness and safety of oral anticoagulants among nonvalvular atrial fibrillation patients.","volume":"49","author":"Lip","year":"2018","journal-title":"Stroke"},{"issue":"5","key":"zoi220834r17","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey.","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"issue":"3","key":"zoi220834r18","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000250","article-title":"A new risk scheme to predict ischemic stroke and other thromboembolism in atrial fibrillation: the ATRIA study stroke risk score.","volume":"2","author":"Singer","year":"2013","journal-title":"J Am Heart Assoc"},{"issue":"20","key":"zoi220834r19","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1093\/eurheartj\/ehw054","article-title":"The ABC (age, biomarkers, clinical history) stroke risk score: a biomarker-based risk score for predicting stroke in atrial fibrillation.","volume":"37","author":"Hijazi","year":"2016","journal-title":"Eur Heart J"},{"issue":"46","key":"zoi220834r20","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1093\/eurheartj\/ehv476","article-title":"The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.","volume":"36","author":"O\u2019Brien","year":"2015","journal-title":"Eur Heart J"},{"issue":"3","key":"zoi220834r21","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.ahj.2005.04.017","article-title":"Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF).","volume":"151","author":"Gage","year":"2006","journal-title":"Am Heart J"},{"issue":"10","key":"zoi220834r22","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart Disease and Stroke Statistics-2019 update: a report from the American Heart Association.","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"issue":"3","key":"zoi220834r23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/NRL.0b013e31815cffae","article-title":"Clinical epidemiology of atrial fibrillation and related cerebrovascular events in the United States.","volume":"14","author":"Lakshminarayan","year":"2008","journal-title":"Neurologist"},{"issue":"2","key":"zoi220834r24","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jacc.2017.10.085","article-title":"Relationship of aging and incident comorbidities to stroke risk in patients with atrial fibrillation.","volume":"71","author":"Chao","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"zoi220834r25","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.005","article-title":"Geographic disparities in the incidence of stroke among patients with atrial fibrillation in the United States.","volume":"28","author":"Claxton","year":"2019","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"2","key":"zoi220834r26","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1161\/STROKEAHA.119.025554","article-title":"Risks of stroke and mortality in atrial fibrillation patients treated with rivaroxaban and warfarin.","volume":"51","author":"Alberts","year":"2020","journal-title":"Stroke"},{"issue":"6","key":"zoi220834r27","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1212\/01.wnl.0000267275.68538.8d","article-title":"Independent predictors of stroke in patients with atrial fibrillation: a systematic review.","volume":"69","author":"Stroke Risk in Atrial Fibrillation Working Group","year":"2007","journal-title":"Neurology"},{"issue":"13","key":"zoi220834r28","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1001\/archinte.1994.00420130036007","article-title":"Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials.","volume":"154","year":"1994","journal-title":"Arch Intern Med"},{"issue":"2","key":"zoi220834r29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/20009666.2019.1593781","article-title":"Stroke risk stratification in atrial fibrillation: a review of common risk factors.","volume":"9","author":"Oladiran","year":"2019","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"zoi220834r30","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2147\/VHRM","article-title":"Strokes in young adults: epidemiology and prevention.","volume":"11","author":"Smajlovic","year":"2015","journal-title":"Vasc Health Risk Manag"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2795797\/lip_2022_oi_220834_1661274146.16137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T15:33:07Z","timestamp":1661959987000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2795797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.29333","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]}}}